DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8097 and RARS2

DIOPT Version :9

Sequence 1:	NP_001285279.1	Gene:	CG8097 / 32495	FlyBaseID:	FBgn0030660	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_001337434.1	Gene:	RARS2 / 57038	HGNCID:	21406	Length:	588	Species:	Homo sapiens

Alignment Length:	492	Identity:	101/492 - (20%)
Similarity:	185/492 - (37%)	Gaps:	155/492 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDCNPRLQVGQQLFEFFTKPEKPDESGGDVAAPLLLKKFGKLIRYNNDDLTEQGDLTLAAIPRYW 65
            :..||.    |.|||.:.:..|  |:..|.:.....::|.:.:        |.||:...::   |
Human   194 LQSNPL----QHLFEVYVQVNK--EAADDKSVAKAAQEFFQRL--------ELGDVQALSL---W 241

  Fly    66 QKYLKSQGLKLRIDGDELLPSPVDRLELMEHSRKWRFPLAEITVLNKERYSLRFQRHPI--IAHV 128
            ||:..                    |.:.|:.|.::    .:.|...|.....|.|...  :..:
Human   242 QKFRD--------------------LSIEEYIRVYK----RLGVYFDEYSGESFYREKSQEVLKL 282

  Fly   129 LNS----VLTLRGD--YGRSANNNQSRTICLQLQA-------------------------VVGAV 162
            |.|    :.|::|.  ...|.|.:.| :||..:::                         ::...
Human   283 LESKGLLLKTIKGTAVVDLSGNGDPS-SICTVMRSDGTSLYATRDLAAAIDRMDKYNFDTMIYVT 346

  Fly   163 DGGQDLRHYRLQQLYKILLRLVDYSSWRLVEPNDRQKDTICVTVELEKCCNGKQPVEHVCLTCGP 227
            |.||. :|:  ||::: :|:::.| .|                  .|:|       :||     |
Human   347 DKGQK-KHF--QQVFQ-MLKIMGY-DW------------------AERC-------QHV-----P 376

  Fly   228 --VLEPINKGASSLT----VDEYLKLR-CQHMELMATQRSGMCPVPMSSLDTLTKRLAAAAVIVD 285
              |::.:......:|    |...::|| .|:|..:.|.:.      :.:.....:|:..||:|:.
Human   377 FGVVQGMKTRRGDVTFLEDVLNEIQLRMLQNMASIKTTKE------LKNPQETAERVGLAALIIQ 435

  Fly   286 LFV------VRHS-SAVSVVRNGVGICKGASYILYNSARLEALLRKFNYEVNNCAYEKLPLLDEI 343
            .|.      .:.| ..|...|...|:     ::.|..|||.:|...|     .|.|     |::.
Human   436 DFKGLLLSDYKFSWDRVFQSRGDTGV-----FLQYTHARLHSLEETF-----GCGY-----LNDF 485

  Fly   344 DLSVLEDDVDWELIYGYLLTFPELMESIMDQLDQGHCGLHLLVHYVENLAAAFSRFYYHKKVLLQ 408
            :.:.|::.....::. :||.|.|::..........|...:||.  :.:|||.     .||  .||
Human   486 NTACLQEPQSVSILQ-HLLRFDEVLYKSSQDFQPRHIVSYLLT--LSHLAAV-----AHK--TLQ 540

  Fly   409 KRDELMPILYARIYLIKAVRQVLNTALAVLGIEPVDY 445
            .:|....:..||::|.||||.||...:.:|||.|:::
Human   541 IKDSPPEVAGARLHLFKAVRSVLANGMKLLGITPMEF 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8097	NP_001285279.1	DALR_1	311..445	CDD:214846	38/133 (29%)
RARS2	NP_001337434.1	tRNA-synt_1d	36..576	CDD:332079	101/489 (21%)
		'HIGH' region	133..144
		L-arginine binding. /evidence=ECO:0000250\|UniProtKB:P54136	133..135
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0018
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810