Protein Alignment Gmap and Trip11

DIOPT Version :10

• Sequence 1: NP_001356946.1
• Gene: Gmap / 32483
• FlyBaseID: FBgn0027287
• Length: 1401
• Species: Drosophila melanogaster
• Sequence 2: NP_001399122.1
• Gene: Trip11 / 314393
• RGDID: 1586166
• Length: 1974
• Species: Rattus norvegicus
• Alignment Length: 1793
• Identity: 403/1793 - (22%)
• Similarity: 723/1793 - (40%)
• Gaps: 504/1793 - (28%)

  Fly     5 NSSLSQLKGQLTNLAQEVLAETAGPGDLE---YEGHQAGGASVQDAE--QQAKTALELLAETQEQ 64
            :|.:.:::..:.:|..|.:..:....|||   .|.|:...::..|.|  ::.:..||:      :
  Rat   282 HSKVYEMQNTIQSLQMERVESSRKIEDLENKIKEIHKRLSSAEHDREVCKKEQERLEM------E 340

  Fly    65 KEQLDKRCEE-----KDREIAALRRELAKSKQKQESQLAASTSATREPQLQNEEPNVEDSWCWEP 124
            |.|:.::||.     ::.:.:|||  |..:..:.|..|:.|.|.....:||....:.|:
  Rat   341 KRQMAEQCERLKLDCREAQQSALR--LTDAVTEDERSLSQSASVAEVLRLQQALTDAEN------ 397

  Fly   125 DGGDEKGATGAGSGDSASRDKESGLVDIALGNDDVVRLNNRIAELEQLNEQLNVSLEELDSQHEL 189
               :.|..:......:.:.|.:.  :.:.     |..|....:.|.|..|:|..||..|..::|:
  Rat   398 ---EVKRLSSLNQDTNLAEDNQK--LQMC-----VQTLEKEKSLLSQEKEELQTSLSRLSHEYEV 452

  Fly   190 ----AMRDVLEHKTQLAGQVASLK-QLQADRLVEHELSNARQQK-----QLDELRQTSSAAKKQ- 243
                |.||     :.|:.||..|| .|:|.   |.||:.:..:.     :|:||.:.:..|.|.
  Rat   453 IKSTATRD-----SDLSSQVHDLKHNLEAK---EQELNQSIHENEILMAELEELDKQNQEATKHV 509

  Fly   244 ---QEELQRRVEQQEAELIEMQDLLDKRRQDTAEL-------IERVRVAE---TERERLLKDLEE 295
               :|:|.::..:.::.:..:::.||..::.|.:|       |:.:.|.:   |..|::|.||:.
  Rat   510 ILIKEQLSKQQSEGDSVIKRLKEELDDEKKRTHQLEDDKMNIIKELNVQKEKLTHSEQVLSDLQL 574

  Fly   296 TRQAKEKKT-------SESSSNSSSTGK----------HSEDEFIVVR----QADATGSGSASGS 339
            |:|..|.|.       |:|..|:....|          .:|:|...||    |:...||.|....
  Rat   575 TKQKLEGKVEDLVDQLSKSEKNNFDIQKENRELREHIRQNEEELSTVRSELTQSQTQGSNSNLKD 639

  Fly   340 D--RDPDADVTSPPSKEKLRDRLVSLESQISE--------LTLANTQLQDA--QLEKQLSINMLG 392
            |  |:.:.:|.|      |:..|..:| |::|        |.:.|.:|..|  .:..||..::.|
  Rat   640 DLLREKETEVQS------LKQNLSEIE-QLNEHLKQVAFDLRIENEKLVVACEDVRNQLEESVAG 697

  Fly   393 EQLVELEKRLRLSEAEKEQLQV---NLQLRL------QQLTVQ---------------NQELKLH 433
            ...:.|||...| |.||.||:.   ..:.||      .:.|||               .||..:.
  Rat   698 NNQISLEKAAIL-EWEKAQLEAEPCRAEKRLLEEGRKYRQTVQGPSSTHSPDASALQLEQERLIQ 761

  Fly   434 AEAEQEGHAQNLEEQLGDLREDNQRLRQELKTSIAQAK-FRQAIAEEKQEITDLDDADSEYGTFE 497
            ...|::.....|::.:..:..|:::.::.|.:|:.:.| ..|.|.|::..|..|.:..||... |
  Rat   762 LNQEKDFEIAELKKSIEQMDTDHKQTKETLSSSLEEQKQLAQLINEKEICIVKLKEKSSELQR-E 825

  Fly   498 LDKL-RAL-----LQAEIEDRLDSSFPQQKLERAWNALKDRWHRLDLVEQRLVDVQNQQLVSEHE 556
            ||:. :||     |:..||:: |.|....|.|.  |.|::...||...:.|.|.|...:.:....
  Rat   826 LDRCSQALRKNETLRQTIEEK-DRSLGSMKEEN--NHLQEELERLREQQSRAVPVPEPRTLDSTT 887

  Fly   557 KKTLEADISQYILQCDEL---MKNNDLLLNELDKYKRNKLETIEE----------HHEE------ 602
            :  ||:::||.....|.|   :|::..::.:.::.|...|::::|          .||:
  Rat   888 E--LESELSQLHTIKDHLEEEIKHHQKMIEDQNQNKMQLLQSLQEQKKAMDEFKYQHEQMSITHS 950

  Fly   603 ---------------TIVQLEAQLEEAR-----------QKLELASLSSQQQMETHLISSPEKTP 641
                           ||.|::|||:|.|           |:.::.||:.:...|.|.:|..|
  Rat   951 RLFLEKDEEIKNLQKTIEQIKAQLQEERQDSQTENSDIFQETKVQSLNIEIGSEKHDLSKAE--- 1012

  Fly   642 VDSELLAK-MEQKEQEYLQLQEQLAFAKTELDKRNKLLERNGEQLTKQQQQNQADQKKLEELSQL 705
              :|.|.| ::::|.|.                  |||......|||     |.||...:|:.:|
  Rat  1013 --TERLVKGIKERELEI------------------KLLNEKNISLTK-----QIDQLSKDEVGKL 1052

  Fly   706 RETLQRRD----------------EDLKELEEQLSAVRQD-------LDEKSIQ-MKISQDQHKL 746
            .:.:|::|                :|:..|::|:.|...:       |.||:.: .|:..:.||:
  Rat  1053 TQIIQQKDVEIQALHARISSASYSQDVVYLQQQVQAYAMEREKVMVVLSEKTRENSKLKSEYHKM 1117

  Fly   747 ---------QLANLQNQ-----------------------------------------------L 755
                     .|..||::                                               |
  Rat  1118 IDILSAKEAALIKLQDENKKMSTRFESSGQDMFKETIQNLSRIIREKDIEIDALSQKCQTLLTVL 1182

  Fly   756 Q----------ADQEKLRELLQLQDKLEQQKELMEVDQNQQITIIKK---ELAETTNQLSECQER 807
            |          .:..:..||||.:|||:||.:.||..:.|.:|.::.   |.|:...:|.:.|.:
  Rat  1183 QTSGTGSEVGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQ 1247

  Fly   808 LTVKE----------------------------AQLAEIQQQL---------------------- 822
            ::|..                            .:||::|..:
  Rat  1248 VSVDSDNNTKLQVNYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCTTKDLLLGKLDSMSPQLS 1312

  Fly   823 -----------------------------QEVNEERTRLQEQLLTKEQESGLDSELAKRNQELED 858
                                         |||::.|..|||:..|..       .|.:.|..|.|
  Rat  1313 PGSSLTTQAAEPLKASQCSGPHESSHLLQQEVDDLRKSLQEKDATIR-------TLQENNHRLSD 1370

  Fly   859 QLLA----KEQQLQLNQAELEKLQETLRVNEEQLLAKEEQLHAKESQLQSLESQLQGQLAADESQ 919
            .:.|    :.::.:...:|:::|:|...|.:..|..|:..:.||..||.|.......:::  |::
  Rat  1371 SMAASSEGERKEHEQTDSEVKQLKEKQEVLQNLLKEKDLLIKAKSDQLHSSNENFANKVS--ENE 1433

  Fly   920 QLQQTIDGLGQE-----------KNELIKVLQQKHQENTQYYAEIQRLQPFEQQVKE-------- 965
            .|:|.:..|.:.           |.|..||::....:.|:|.|..:....|...::|
  Rat  1434 LLRQAVTNLKERILILEMDISKLKGENEKVIEASKGKETEYQALQETNMKFSMMLREKEFECHSM 1498

  Fly   966 ---------LVKEREK---------------LQDQVGFLKEKSDILTTNLLTEQTNQRLLQQQQA 1006
                     |:||:|:               :|::....:::.|.:...|..:|.....||.:..
  Rat  1499 REKALAFEQLLKEKEQGKAGELNQLLNAVKSMQEKTVTFQQERDQVMLALKQKQMETSTLQNEVQ 1563

  Fly  1007 ESQEQQASTLRDLERLRAHLLEIEELHTQETVELQRDLEESRSRQAILEQQVSKSSTAYTSASIR 1071
            ..::::|...::|:|||.||||.|:.||:|.:..:....:.|.:.::||:::..||.|..:||.:
  Rat  1564 RLRDKEARLNQELQRLRDHLLESEDSHTREALAAEDREAKLRKKVSVLEEKLVSSSNAMENASHQ 1628

  Fly  1072 ANQQAETLQAQHALLQQQRDELLAKLGQYEDRELKQQA-ALTNLQCALEQFQNDKDHDIEMATQR 1135
            |:.|.|:||.|..::.:||||...:|...:: ::||.| :|||||..||.||.::
  Rat  1629 ASVQVESLQEQLNMVSKQRDETALQLSVSQE-QVKQYAMSLTNLQMVLEHFQQEE---------- 1682

  Fly  1136 IRREMQAQLDRQGQLQLE-----------MSGLQQQLAEANQGLRAAARLSDQLEAGQQTIAVLR 1189
             :....|:|::|.||..|           :..||::|.|||..|.:|:||::||:..::.|..|:
  Rat  1683 -KAMYSAELEKQNQLLTEWKKKAESLEGKVLSLQERLDEANAALDSASRLTEQLDLKEEQIEELK 1746

  Fly  1190 DEVESLKEANGQLEQRLSSSESSQTDKIDKSLIKSLLIGYVVSGHA--GDKQQVLRMISSVLDFN 1252
            .:.|..:|.....:::|.|..:|...|:||.|:::|.||:.   |.  ..:.:|||::.|:|...
  Rat  1747 KQNELHQEMLDDAQKKLMSLVNSTEGKVDKVLMRNLFIGHF---HTPKNQRHEVLRLMGSILGVK 1808

  Fly  1253 AQEADKVGLNKQ--QSSWLGAILGGGSATASAA-----GSSRGNENLVQAFVQFLEQESQPQAQS 1310
            .:|.:::....|  .:.|:...|||||.:....     ..|..|.:..:.||:|||.||.|...
  Rat  1809 REEMEQLFAEDQGGVTRWMAGWLGGGSKSVPNTPLRPNQQSVFNSSFSELFVKFLETESHPSVP- 1872

  Fly  1311 RPTLLSM--TGQMDGVTSASATTSTAATSGHLPQASSSFSPAT---PAASQQDPAAPRTPPVGGS 1370
             |..||:  ...:|........|.||  .|....|.|.....|   |..:.:..|.|...|.|..
  Rat  1873 -PPKLSVHDLKPLDSPGRRKVDTGTA--EGFRDTAESRAGRRTDMNPFLAPRSAAVPLINPAGHG 1934

  Fly  1371 P----QLLAMGSNEFAPT---------RNSSSILKDIL 1395
            |    .||....::..||         .::..:|||:|
  Rat  1935 PGGPGHLLLKPISDVLPTFTPLPVSPDNSAGVVLKDLL 1972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gmap	NP_001356946.1	SMC_prok_B	169..973	CDD:274008	241/1156 (21%)
		Smc	<645..>1195	CDD:440809	166/781 (21%)
Trip11	NP_001399122.1	SMC_prok_B	242..1063	CDD:274008	195/854 (23%)
		SMC_prok_B	812..1747	CDD:274008	215/989 (22%)
		GRAB	1769..1814	CDD:431241	15/47 (32%)