Protein Alignment Gmap and sql-1

DIOPT Version :10

• Sequence 1: NP_001356946.1
• Gene: Gmap / 32483
• FlyBaseID: FBgn0027287
• Length: 1401
• Species: Drosophila melanogaster
• Sequence 2: NP_001255174.1
• Gene: sql-1 / 190949
• WormBaseID: WBGene00013730
• Length: 1328
• Species: Caenorhabditis elegans
• Alignment Length: 1597
• Identity: 364/1597 - (22%)
• Similarity: 639/1597 - (40%)
• Gaps: 477/1597 - (29%)

  Fly     3 WLNSSLSQLKGQLTNLAQEVLAETAGPGDLEYEGHQAGGASVQDAEQQAKTALELLAETQEQKEQ 67
            ||.:    ::||||:||.|||.|                            |.::|||..|:
 Worm     4 WLRN----IQGQLTDLANEVLNE----------------------------ANDVLAEATEE--- 33

  Fly    68 LDKRCEEKDREIAALRRELAKSKQKQESQLAASTSATREPQLQNEEPNVEDSWCWEPDGGDEKGA 132
                .::.|.||...:::.|::    |.|||..||  |...|.||:.::|....   |...|..|
 Worm    34 ----VQDPDGEIIVAKKKAAEA----EKQLAIETS--RVELLGNEKSHLEQQLY---DAHVEMDA 85

  Fly   133 TGAGSGDSASRDKESGLVDIALGNDDVVRLNNRIAELEQLNEQ-LNVSLEELDSQHELAMRDVLE 196
            .||         |.:|:|  ...:|::.:|.   .::|||.|. .|.|..::|...||..
 Worm    86 IGA---------KFNGMV--KQRDDEIKKLK---TQMEQLQESGWNESTSDIDQICELKK----- 131

  Fly   197 HKTQLAGQVASLKQLQADRLVEHELSNARQQKQ---LDELRQTSSAAKKQQE-ELQRRVEQQEAE 257
                   ||:..|.|..::..:......:::::   |.||.:...|.::|:| |:|..||.....
 Worm   132 -------QVSHWKSLAEEKSGDGGGGGEKEEEEMIKLSELEKRIEALRQQKEHEIQSLVESHAEN 189

  Fly   258 LIEMQDLLDKRRQDTAELIERVRVAETERERLLKDLEETRQAKEKKTSESSSNSSSTGK---HSE 319
            ::||:::.::            ::|             ..|......|.|:||:.:...   ..|
 Worm   190 VLEMREMYEE------------KIA-------------AMQVLPYNASSSTSNADALDAVMLERE 229

  Fly   320 DEFIVVRQADATGSGSASGSDRDPDADVTSPPSKEKLRDRLVSLESQISELTLANTQLQDAQLEK 384
            |..::..|....||....| :|....|:.|       .|.||.
 Worm   230 DLLLLQHQKSTNGSDGGDG-ERPVVVDLGS-------HDELVD---------------------- 264

  Fly   385 QLSINMLGEQLVELEKRLRLSEAEKEQLQVNLQLRLQQLTVQNQEL-----KLHAEAE--QEGH- 441
                    |::.::|..|:....||.:.|.|...:::.|..||:||     :|:.|.|  :|.|
 Worm   265 --------ERIRQMEVELQRCRDEKMECQHNSDAQIEDLKTQNKELANAYTELNEEFEGFKEQHT 321

  Fly   442 -AQNLEEQLGDLREDNQRLRQELKTSIAQAKFRQAI-----AEEKQEITDL-------------- 486
             .||....|      |:|: ..||.::.:.:.|..|     ||...::..|
 Worm   322 ATQNANNDL------NRRI-DSLKANLIEYEERYEICKKESAETASQLIKLTNDFARLKTGVDSV 379

  Fly   487 ----DDADSEYGTFELDKLRALLQAEIEDRLDSSFPQQKLERAWNALKDRWHRLDLVEQRLV--D 545
                :|.|:.... |:|||||.|:...:||.......||.:.|...:.....:|....:.|:  :
 Worm   380 SQRREDCDTMVNE-EVDKLRASLEETRQDREHLRSDVQKFQVAVGEIDVELDKLREANRLLLGEN 443

  Fly   546 VQNQQLVSEHE--KKTL----EADISQYILQCDELMKN-----------NDLLLNELDKYKRNKL 593
            |..|:.::.:|  .|:|    |.||.::..|..|:.:|           ||.|..|....||.:.
 Worm   444 VALQENLANYEDTMKSLISSSEQDIGKFREQFGEIQENHKQQREAMIAENDALREESAAIKRQRD 508

  Fly   594 ETIEEHHEETIVQLEAQLEEARQKLELASLSSQQQMETHLISSPEKTPVDSELLAKMEQKEQEYL 658
            ..:||         .|.|:|..:||:..|.:.:.::|                   :.||:.:.|
 Worm   509 IVLEE---------SALLKEVNEKLKQKSATEESKIE-------------------LLQKKADLL 545

  Fly   659 Q--LQEQLAFAKTELD-----KRNKL-------LERNGEQLTKQQQQNQADQKKLEELSQLRETL 709
            :  |:|:.|..:.|.|     |:|.|       .:.:.|..|::|:.|  ::.|:.:| ||||.|
 Worm   546 EQVLEEERANHQREKDEAVEQKKNNLESQIQCDADDDDENSTEEQKLN--NEIKILKL-QLREAL 607

  Fly   710 QRRDEDLKE----------LEEQLSAVRQDLDEKSIQ---MKISQDQHKLQLANLQNQLQADQEK 761
            ....|..:|          ||.::...:..:||...|   :::.|:.....:..||.|:.|::
 Worm   608 DANTEKTEECEKLHIETRNLEREVDLRQNCVDEMIAQTNTLQMQQESMSTAMKTLQKQILANE-- 670

  Fly   762 LRELLQLQDKL------EQQKELMEVDQNQQITII--------------------KKELAETTNQ 800
             ||:.||::||      .|:.|  |..:|.:..|:                    :.|::.....
 Worm   671 -REICQLEEKLTESELKTQRSE--EKVKNLEDFIVGERMEEAEAEAEAAADGGGARNEVSHLKRY 732

  Fly   801 LSECQERLTVKEAQLAEIQQQLQEVNEERTRLQEQL-----LTKEQESGLDSELAKRNQELEDQL 860
            :::.|.:|:..|.:|..:::|..:.|.|.|::::.|     ..:|.:.||...:..|.:|:||||
 Worm   733 IADLQSKLSTMEEELKVLREQKLDENNEATQVRQMLERDLFEAEEVDRGLLEGIENRVKEMEDQL 797

  Fly   861 LAKEQQLQLNQAELEKLQETLRVNEEQLLAKE-------------EQLHAKESQLQSLESQLQGQ 912
            .||.:.|:..:.|..||::.|...|::.:|.|             |:|..||:..|:..||...:
 Worm   798 EAKVKALKEAKEESSKLEKKLEKAEKERIALEVLEEQNRFLNEKLEKLMEKENSDQTGASQATAE 862

  Fly   913 LAADESQQLQQTID----------------GLGQEKNEL-------------------------I 936
            |......||.:.::                ||.:..:||                         |
 Worm   863 LQNSSISQLTEQLESVKAENARLASEIEKSGLSENSDELRALQLENEQLKLSQSTSSTEELRAAI 927

  Fly   937 KVLQQ-----------KHQENTQYYAEIQRLQPFEQQVKELVKEREKLQDQVGFLKEKSDILTTN 990
            .||||           :::|:.:||.:.|.:....||:.:   :.|::|.|           ||
 Worm   928 AVLQQENEHLKGVAKTQYEESVKYYEQFQAMVTHNQQMSD---QMEQVQRQ-----------TT- 977

  Fly   991 LLTEQTNQRLLQQQQAESQEQQASTLRDLERLRAHLLEIEELHTQETVELQRDLEESRSRQAILE 1055
                     ::|...|...|.....:::|:|||.||:.:||..|:|.||.::...|.|:|...||
 Worm   978 ---------VIQGTMAAENEAHEKKVKELQRLREHLMIVEETSTREAVEAEQRETELRARVRELE 1033

  Fly  1056 ---QQVSKSSTAYTSASIRANQQAETLQAQHALLQQQRDELLAKLGQYEDR-------ELKQQAA 1110
               .||.:.          |::..:..|.|.|.|..|.:.|..|..:::.:       ..:.|.|
 Worm  1034 TKGHQVEEG----------ASESTQQYQVQIASLTSQVESLQNKTTEWKKKFETEVSARQQTQEA 1088

  Fly  1111 LTNLQCALEQFQNDKDHDIEMATQRIRREMQAQLDRQGQLQLEMSGLQQQLAEANQGLRAAARLS 1175
            ||:||..:.:...|.:.|...|:.| ..|:|..:   |.|..|::.:::.|...:.|.:|:...|
 Worm  1089 LTSLQNVVRELSIDHEKDSAFASHR-NLELQTMI---GTLNEEIAQIREDLDRQSLGKQASEEES 1149

  Fly  1176 D----QLEAGQQTIAVLRDEVESLKEANGQLEQRLSSSESSQTDKIDKSLIKSLLIGYVVSGHAG 1236
            :    ||::.|:.|..|..::|.|:          |..:.:::.:||.|.::.|.:.|.|| .|.
 Worm  1150 ERRQLQLDSKQKIIEDLEVQIEELR----------SPKKPTESYRIDDSTLRQLFLSYFVS-DAA 1203

  Fly  1237 DKQQVLRMISSVLDFNAQEADK--------VGLNKQQSSWLGAILGGGSATASAAGSSRGNENLV 1293
            .:..:..::::||::.|:|.||        .|..:||.| .....|...:|....|.:     :.
 Worm  1204 KRPDIALLLANVLEYPAEEMDKFKSAVRQSFGQQQQQQS-SSFFFGSARSTPPPNGPT-----IA 1262

  Fly  1294 QAFVQFLEQESQPQAQSRPTLLSMTGQMDGVTSASATTSTAATSGHLPQASSSFSPATPAASQQD 1358
            ..||:|||.||:                           ::.|:.|||..|.. .|:||..|.:.
 Worm  1263 DQFVRFLEAESE---------------------------SSRTAPHLPIRSQQ-QPSTPGLSLES 1299

  Fly  1359 PAAPRTPPVGGSPQLLAMGSNEFAPTRNSSSILKDIL 1395
            | ..::|    :||    .|::.|...:|::.|..||
 Worm  1300 P-RQKSP----NPQ----NSSQTASASSSAAALDSIL 1327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gmap	NP_001356946.1	SMC_prok_B	169..973	CDD:274008	214/985 (22%)
		Smc	<645..>1195	CDD:440809	159/686 (23%)
sql-1	NP_001255174.1	SMC_prok_B	<159..524	CDD:274008	97/444 (22%)
		SMC_prok_B	<391..1173	CDD:274008	199/856 (23%)