Protein Alignment Gmap and trip11

DIOPT Version :10

• Sequence 1: NP_001356946.1
• Gene: Gmap / 32483
• FlyBaseID: FBgn0027287
• Length: 1401
• Species: Drosophila melanogaster
• Sequence 2: NP_001265632.1
• Gene: trip11 / 100537975
• ZFINID: ZDB-GENE-030131-9833
• Length: 1984
• Species: Danio rerio
• Alignment Length: 1863
• Identity: 428/1863 - (22%)
• Similarity: 750/1863 - (40%)
• Gaps: 534/1863 - (28%)

  Fly     3 WLNSSLSQLKGQLTNLAQEV-----------LAETAGPGD-------------------LEYEGH 37
            |....:::|..::..|..:|           |....|.||                   .|.:.|
Zfish   184 WSQQEINRLSNEVHRLEADVSHWRRVAQVSKLPGADGNGDQGEVLKMQRIIKELRDKMAREVDEH 248

  Fly    38 QAGGASVQDAEQQ-----AKTALELLAETQEQKEQLDK--------------------RCEEKDR 77
            |...|::|||::|     :|...:.|||.:|:.|:|::                    :.:|.:.
Zfish   249 QHELAALQDAQRQKMSDISKRHRQELAEYEERIEELEEQLQSEGGNAVQKSSTMQDSIKLQELES 313

  Fly    78 EIAALRRELAKSKQKQESQLAAS--------TSATREPQ---------LQN-----EEPNVEDSW 120
            .|.:|:.| |:.::||..:|.|:        |...||.:         |||     :..|...:.
Zfish   314 TIRSLQEE-AELQRKQHRELLATLEEAEHHKTKLEREKEEATAENAELLQNYSRLQKSVNELQAR 377

  Fly   121 CWEPDGGDEKGATG-----------AGSGDSASRDK---ESGLVDIALGNDDVVRLN-------- 163
            ..|.:|.....|..           ||:....:|.|   |||.:: .:.:.|::.||
Zfish   378 VQEQEGKSMLKAQHDNEIQVLKKALAGAEKEVARLKSFSESGPME-EVEHADILELNTIIDTLRK 441

  Fly   164 -------------NRIAELEQLN------------------------------------EQLNVS 179
                         :|||.:|:.:                                    |.|...
Zfish   442 EKEEVEKEKLVLLDRIALVEERHRSGEPESVGELSLEVSDLKSQLDQREEALKQAHLDIETLTAE 506

  Fly   180 LEELD------SQHELAMRDVLE-HKTQLAGQVASLK-------------QLQADRLVE------ 218
            |||||      :||.:|::|.|. .|||...:.|.|:             ||:.:..||
Zfish   507 LEELDKQNQEATQHVIAVKDQLSLQKTQTEAEKARLQSDLNSLLDQRQSLQLELEAHVEKLSQSA 571

  Fly   219 ---HELSNARQQ-----KQL-----------DELRQTSSAAKKQQEELQRRVEQQEAELIEMQDL 264
               :||..|:||     |:|           .||||.||       ||:|.::|:|.||..:.:.
Zfish   572 FSLNELHMAKQQLEATVKELREKLCKSQDLGKELRQESS-------ELKRALQQRETELTALHEE 629

  Fly   265 LDKRRQDTAELIERVRVAETERERLLKDLE----ETRQAKEKKTSESSSNSSSTGKHSEDEFIVV 325
            |....:...||....::.|. |::.:.||:    |.:.:.|:..||.........|.:|:....:
Zfish   630 LSHTGEQRNELEVHRKILEA-RDKDIHDLKAELAEVKVSYERAVSEDFELKIDNRKLTEERTRTL 693

  Fly   326 RQADATG------SGSASGSDRDPDADVTS------------PPSKEKLRDRLVSLESQISELTL 372
            .:.|:..      ..|.|....:.|..:.:            ..::::|.|:....:..|.|||.
Zfish   694 EKTDSLERHIQECQASLSRMSLEKDTRIEALKLEKSQLESELSQTEKRLSDQAKQYQQTIDELTR 758

  Fly   373 ANT------QLQDAQL-----EKQLSINMLG---EQLVELEK----RLRLSEAEKEQLQVNLQ-- 417
            |.:      |.:..::     ||.|:|:.|.   ||::..:|    .|.::.|.:.||...||
Zfish   759 ARSMDASALQTEHERMVKLNQEKDLTISELRREIEQMISDQKDTSEMLDITVAGQNQLTELLQEK 823

  Fly   418 ------LRLQQLTVQNQELK---LHAEAEQEGHAQNLEE---QLGDLREDNQRLRQ--------- 461
                  |:.|.:..| |||:   |.|..|.:...:::||   |||.::|:|..|::
Zfish   824 DAFAETLKTQAVETQ-QELETRILRASQECDSLRKSVEEKDKQLGAMKEENSHLKEEIDRLRDQQ 887

  Fly   462 ----------------ELKTSIAQAK-FRQAIAEEKQEITDLDDADSEYGTFELDKLRALLQAEI 509
                            ||:..:||.| .|..:.||.|.:..|.:   |..|..|...|: ||:|:
Zfish   888 SRPQLMSEPRTLDIITELENEVAQLKAARDQLKEEVQALRRLSE---EQQTTALQSQRS-LQSEL 948

  Fly   510 EDRLDSSFPQQKL--ERAWNALKDRWHRLD-----LVEQRLVDVQNQQLVSEHEKKTLEA----- 562
            | :..|...|..|  ||..:|..:...||.     |..|....:|:.:::.|.:.::|..
Zfish   949 E-QARSRNEQSALNYERLISAKDEEIARLQSEVEGLSTQGRSQIQSVEILQEDKTQSLNGENGNE 1012

  Fly   563 --DISQYILQCDELMKNNDLLLNELDKYKRNKLETIEEHHEETIVQLE-AQLEE-ARQK-LELAS 622
              |:|:  ::.::|:|.......|:::.....|...::..:..:.|.| .:|.: .||| ||:.:
Zfish  1013 KHDLSK--VEIEKLVKGIKEKETEINQLNEKNLCLTKQLDQLVVSQNELGKLSQMVRQKDLEIQA 1075

  Fly   623 LSS-------------QQQMETHLISSPEKTPVDSELLAKMEQKEQEYLQLQEQLAFAKTELDKR 674
            |.:             |||::.:.:..       .::||.:.:|.:|..||       :::..:.
Zfish  1076 LHARVSGGHGQDVVFLQQQLQAYAVER-------EQVLAVLNEKTRENSQL-------RSDYHRI 1126

  Fly   675 NKLLERNGEQLTKQQQQNQ-----ADQKKLEELSQLRETLQRRDEDLKELEEQLSAVRQDLDEKS 734
            ..::......|.|.||:||     :|....:|:  .|||:|.....::|.:.::.|:.|     .
Zfish  1127 MDIVAAKEAALLKLQQENQRLSTMSDPSGSQEM--FRETIQNLSRIIREKDIEIDALTQ-----K 1184

  Fly   735 IQMKISQDQHKLQLANLQNQLQ-----ADQEKLRELLQLQDKLEQQKELMEVDQNQQITIIK--- 791
            .|..:|    .||.:...:.:.     ....:..||||.:|.|:||.:.||..:.|.||.::
Zfish  1185 CQTLVS----VLQTSGCSDPVSGGSGGVSSNQFEELLQERDTLKQQVKKMEEWKQQVITTVRNMQ 1245

  Fly   792 -------KELAETTNQLS---------------------ECQERLTVKEAQLAEIQQQLQEVNEE 828
                   :||.:...|:|                     :.:::|.:...:||::||.:.::...
Zfish  1246 HESAQLHEELLKLQGQVSADSDSSSKLSVDYARLIQSYEQKEKKLGLLSQELAQVQQTISQLTST 1310

  Fly   829 RTRLQEQLLTKEQESGLDS-----ELAKRN------QELEDQLLAKEQQLQLNQAELEKLQETLR 882
            :..|..:|.:.:|...|.:     .||..|      ...:|.:....|.||...||.|.:..||:
Zfish  1311 KDVLLGKLGSVKQSPELSAMVPSQALAPSNLRGAAPSAQDDHIHQDMQALQRTLAEKESMIRTLQ 1375

  Fly   883 VNEEQL-----LAKEEQ-LHAKE-----SQLQSLESQLQ-------------GQLA------ADE 917
            .|..:|     |::.|| .||:|     .:.:||:..|:             ||::      .::
Zfish  1376 ENNHRLSNSASLSESEQRSHAEELKQAREKQESLQRSLREKDLLIKTKGDQLGQVSETLRNREND 1440

  Fly   918 SQQLQQTIDGLGQE-----------KNELIKVLQQKHQENTQYYAEIQRLQPFEQQVKELVKERE 971
            ::.|:|.:..|.:.           |:|...:..:..::.|::.|    ||....||..|::|||
Zfish  1441 NEVLKQAVTNLKERALILELDVKKLKDENEAIASKAREKETEFRA----LQETNMQVSLLLRERE 1501

  Fly   972 -----------------------------KLQDQVGFLKEKS-------DILTTNLLTEQTNQRL 1000
                                         :|.::|..::||:       |.:...|..:|.....
Zfish  1502 FQFSAVNEKATAMEKMLKDKEQGKSGELNQLLNEVRSMQEKAVLFQQERDQVMMALKQKQMETSA 1566

  Fly  1001 LQQQQAESQEQQASTLRDLERLRAHLLEIEELHTQETVELQRDLEESRSRQAILEQQVSKSSTAY 1065
            ||.:...:::::....:::||||.||||||:.:|:|.:..|....|.|.|..:|:::::.||.|.
Zfish  1567 LQSELQHTRDKEQRLKQEVERLRNHLLEIEDSYTREALSAQDREAELRRRVTLLDERLTSSSNAV 1631

  Fly  1066 TSASIRANQQAETLQAQHALLQQQRDELLAKLGQYEDRELKQQAALTNLQCALEQFQNDKDHDIE 1130
            .|||.:|:.|.|:||.|.....:||||.|.:|...:|:..:...:|:|||..|||||.::.....
Zfish  1632 ESASQQASFQVESLQEQLNGAVRQRDEALIQLRASQDQVNQYAVSLSNLQMVLEQFQQEEKAMYS 1696

  Fly  1131 MATQRIRREMQAQLDRQGQLQLEMSGLQQQLAEANQGLRAAARLSDQLEAGQQTIAVLRDEV--- 1192
            ...::.:||.....::...|:...:.|:..|.|||..|.:|:||:|||:...:.|..|..:|
Zfish  1697 AELEKHKREKMEWRNKAESLEEIAAALRINLDEANAALESASRLTDQLDLKDEQIEDLNKQVEVR 1761

  Fly  1193 -ESLKEANGQLEQRLSSSESSQTDKIDKSLIKSLLIGYVVSGHA--GDKQQVLRMISSVLDFNAQ 1254
             |.|:||..:|...|:::|.    |:||.|:|:|.:||.   |.  ..:.:|||::.:||..:..
Zfish  1762 QEMLEEAQRKLMNLLNTTEG----KVDKVLMKNLYLGYF---HTPQNKRGEVLRLMGNVLGLDRD 1819

  Fly  1255 EAD-------KVGLNKQQSSWLGAILGGGSATASAAGSSRG-------NENLVQAFVQFLEQESQ 1305
            |..       |.|:....||||     ||.|..|...:.:.       |.:..:.||:|||.||.
Zfish  1820 EVGQLLKEEVKSGMTGWVSSWL-----GGRAVQSVPNTPQRPTQAQSLNSSFSEMFVKFLEVESS 1879

  Fly  1306 PQAQS--------RPTLLSMTGQMDGVTSASATTSTAATSGHLPQASSSFSPATPAASQQDP-AA 1361
            |...:        :|......|:....|.||..:.....||   .::...:|.:.|....:| .|
Zfish  1880 PALPAPKLPMYDIKPLSAPPPGRSTANTPASGVSGPGKRSG---DSNPFLAPRSAAVPLLNPTGA 1941

  Fly  1362 PRTPPVGGSPQLLAMGSNEFAPT---------RNSSSILKDIL 1395
            ..|...||  .||....::..||         .:..::|||:|
Zfish  1942 GSTAGAGG--HLLMKPISDALPTFTPVPVSAEASGGAVLKDLL 1982

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gmap	NP_001356946.1	SMC_prok_B	169..973	CDD:274008	238/1116 (21%)
		Smc	<645..>1195	CDD:440809	164/682 (24%)
trip11	NP_001265632.1	SMC_prok_B	308..1174	CDD:274008	197/899 (22%)
		SMC_prok_B	900..1779	CDD:274008	218/914 (24%)