Protein Alignment Top1 and top1mt

DIOPT Version :10

• Sequence 1: NP_511161.2
• Gene: Top1 / 32458
• FlyBaseID: FBgn0004924
• Length: 974
• Species: Drosophila melanogaster
• Sequence 2: XP_031759708.1
• Gene: top1mt / 779551
• XenbaseID: XB-GENE-962427
• Length: 1149
• Species: Xenopus tropicalis
• Alignment Length: 1003
• Identity: 454/1003 - (45%)
• Similarity: 596/1003 - (59%)
• Gaps: 126/1003 - (12%)

  Fly     5 VAAEN-SIHIQNGG-SCEVVQSNGVTTNGHGHHHHHHHSSSSSSSSKHKSSSKDKHRDREREHKS 67
            ::.:| :|..|.|| .|:..:..      .|||           .||.|..:.|: .:|:::|..
 Frog   240 ISKDNRNIQEQKGGLPCKTEKER------DGHH-----------KSKVKKDNVDR-SERKKDHVE 286

  Fly    68 SNSSSSSKEHKSSSRDKDRHKSSSSSSKHRDKDKERDGSSNSHRSGSSSSHKDKDGS-------- 124
            .:..|..|| |..|..|:|.|:.........|:..:.|..|..   |.|..|..||:
 Frog   287 KSGDSEKKE-KGDSEKKERGKNHLCRDSEGGKESLKRGKENKE---SKSEQKAIDGTEGIAQPER 347

  Fly   125 -SSSKHKSSSGHHKRSSKDKE--RRDKDKDRGSSSSSRHKSSSSSRDKERSSSSHKSSSSSSSSK 186
             ...:.|.:||..:.|:::||  :||..|.:..:|:...:.......||:|...:::......:|
 Frog   348 EKKCEDKMASGKERESAEEKETGKRDPLKSKDKTSAGEERKPKKHSHKEKSKEMNRTREKMEDAK 412

  Fly   187 SKHSSSRHSSSSSSKDQPSYDGVFVKPE----PVSQQLMHSGSVDAFQMQQLGSYEAAAAGTNFN 247
            ...|...|....:.:.....:.. ||||    .|.:...||..||
 Frog   413 MSVSRDHHRKGDALEGAVEANEA-VKPERIEVAVGEPKEHSREVD-------------------- 456

  Fly   248 GNGNVAGANYKNGYEESIVDIKKEEESFNNLSQASSCDYSMSQFRADEPPFVVKHEQSYAEEDST 312
                          |:..:.:|..||..|.|   ::.....|:.:..|.. ..|||:.
 Frog   457 --------------EKVHLRVKSFEEELNEL---ANLKMQSSKVKKKERE-TKKHEEK------- 496

  Fly   313 MNYNDHDDDADEMNDDEEDVPLAMRKRKQEATDRPDGGMDNDDDDDIPLLARKKVKKEKIKKESK 377
                                   ..|.|::::|..:|.....:.::..|:..:  .|.:::|..|
 Frog   497 -----------------------REKIKEQSSDGAEGKATKREGEEEELVGEE--AKPRVEKNQK 536

  Fly   378 EKSKKRVKEEPSDDYGNVKPKKKKMKKEPEPAVSPGKRQKAKAKVEEEEVWRWWEEEKRADGVKW 442
            ||.|:|.|:...|:....|.:..:.:|..|...:..|:.|..||.|||..|:|||||...||:||
 Frog   537 EKIKERGKKSSKDEAARDKKQPSRKRKSTETEGTEAKKAKDAAKKEEESKWKWWEEEHYEDGMKW 601

  Fly   443 STLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDF 507
            ..|||:||.|||.||.:|.:|.|||||||::||...||.||||.|||:|:|.|||.|..|||.|:
 Frog   602 KFLEHRGPYFAPPYEPLPDDVSFYYDGKPVKLSPGAEEVATFYGKMLDHEYTTKEAFQKNFFADW 666

  Fly   508 RKSMTPREREIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEALMKEFGFCMIDGHK 572
            |:.||..||::||...||.|.|:..||..::|.|||..||||...|.|...:.:|:|:|::|||:
 Frog   667 REQMTNEERKLIKHLHKCEFSEIHKYFFEKNEARKALPKEEKQKLKEETNKIQEEYGYCILDGHR 731

  Fly   573 EKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKVPSPPPGSRWKEVRHDNTVTW 637
            ||||||::||||||||||:||||||:|.||...||.|||.|:||||.||||.:|||||.||||||
 Frog   732 EKIGNFKIEPPGLFRGRGDHPKMGMLKLRIMPEDVIINCSKESKVPDPPPGHKWKEVRCDNTVTW 796

  Fly   638 LASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVIDKIRATYRDEWKSKEMRVRQRAV 702
            ||||.||:|..:||||||||||||||||..||||||||..|:..|||.||.:|||:||:.|||||
 Frog   797 LASWTENIQSSIKYIMLNPSSKLKGEKDWQKYETARRLKGVVSDIRAQYRVDWKSREMKKRQRAV 861

  Fly   703 ALYFIDKLALRAGNEKDE-DQADTVGCCSLRVEHVQLHKELNGKENVVVFDFPGKDSIRYYNEVE 766
            ||||||||||||||||:| :.|||||||||||||:||:.||:|::.||.|||.|||||||||:|.
 Frog   862 ALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIQLYPELDGQQYVVEFDFLGKDSIRYYNKVP 926

  Fly   767 VEKRVFKNLELFMEHKKEGDDLFDRLNTQVLNEHLKELMEGLTAKVFRTYNASKTLQSQLDLLTD 831
            |||.|||||:||||:|...|||||||||.:||:||::||:|||||||||||||.|||:||..||:
 Frog   927 VEKEVFKNLKLFMENKNPEDDLFDRLNTSILNKHLQDLMDGLTAKVFRTYNASITLQNQLKELTN 991

  Fly   832 PSATVPEKLLAYNRANRAVAILCNHQRSVPKSHEKSMENLKEKIKAKREAIEKCESEYHSRD--- 893
            ....|..|:|:|||||||||:||||||:.||:.||||:||:.||.||.:.:::.:.|..|..
 Frog   992 GEDNVAAKILSYNRANRAVALLCNHQRAPPKTFEKSMQNLQTKIDAKEQQLKEAKKELKSAKAEH 1056

  Fly   894 ------------EKKGKQLERLRDQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKHD 946
                        |||.||:.|:.:||.||:||.||::|||.|||||||||||||||:||||||:.
 Frog  1057 KARKSEKSKKEMEKKKKQVARIEEQLMKLKLQATDKEENKQIALGTSKLNYLDPRITVAWCKKYG 1121

  Fly   947 VPIEKIFNKTQRTKFLWAVHMADENYRF 974
            ||||||:|||||.||.||:.|..||:.|
 Frog  1122 VPIEKIYNKTQREKFAWAIDMTSENFEF 1149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Top1	NP_511161.2	Topoisomer_IB_N_htopoI_like	441..655	CDD:239570	132/213 (62%)
		TOPEUc	585..946	CDD:214661	255/376 (68%)
top1mt	XP_031759708.1	PTZ00121	<65..>566	CDD:173412	83/418 (20%)
		Topoisom_I_N	599..813	CDD:460746	131/213 (62%)
		TOPEUc	744..1121	CDD:214661	255/376 (68%)