Protein Alignment PPYR1 and HABP4

DIOPT Version :10

• Sequence 1: NP_573012.1
• Gene: PPYR1 / 32453
• FlyBaseID: FBgn0030623
• Length: 309
• Species: Drosophila melanogaster
• Sequence 2: NP_055097.2
• Gene: HABP4 / 22927
• HGNCID: 17062
• Length: 413
• Species: Homo sapiens
• Alignment Length: 293
• Identity: 62/293 - (21%)
• Similarity: 107/293 - (36%)
• Gaps: 60/293 - (20%)

  Fly    29 MSQKPQKAARLFQP-KVENKITLTTPLTAPKKERVKDIKVADPLEKEVESVFVTVPKNKLCKTRR 92
            :.:..:::.|.::| :.|.:...|.       |:..|.|..|..:::........|:..:....|
Human   140 LERAERRSYREYRPYETERQADFTA-------EKFPDEKPGDRFDRDRPLRGRGGPRGGMRGRGR 197

  Fly    93 NRPGDRLFD-----------RRSGSKRTGVKAVEKRNGAGAHNWGS------IQQEIDLRQRTNL 140
            ..||:|:||           |..|:.:..|:..:...|.|...|||      ::....:.:.|.:
Human   198 GGPGNRVFDAFDQRGKREFERYGGNDKIAVRTEDNMGGCGVRTWGSGKDTSDVEPTAPMEEPTVV 262

  Fly   141 RTFEGMKLPKVSSFVYEYDSSEET--EQYTLDEWRAMQAQKKQVLNKFIMSDFGTKK-EVTGGSE 202
            ...:|....:..:.|.|.:..|||  ::.|||||:.:|.|.:.      ..:|..:| |.|..|:
Human   263 EESQGTPEEESPAKVPELEVEEETQVQEMTLDEWKNLQEQTRP------KPEFNIRKPESTVPSK 321

  Fly   203 ETVRAEGSGDTDDTKG--LDKTGGTEQTGNTETGERSAGSGETETAAASGVP-DASGGSGGTEGS 264
            ..|..:.....|..|.  .|.:....:..|..|.:.....|        .:| ...|..|||.|.
Human   322 AVVIHKSKYRDDMVKDDYEDDSHVFRKPANDITSQLEINFG--------NLPRPGRGARGGTRGG 378

  Fly   265 GG-------LGGSGEL--------EDDGEELTA 282
            .|       .|...|:        .||.|:..|
Human   379 RGRIRRAENYGPRAEVVMQDVAPNPDDPEDFPA 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPYR1	NP_573012.1	HABP4_PAI-RBP1	96..180	CDD:461421	26/102 (25%)
HABP4	NP_055097.2	IHABP4_N	16..162	CDD:465041	3/21 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..206		13/72 (18%)
		HABP4_PAI-RBP1	212..316	CDD:461421	24/109 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	227..320		24/98 (24%)
		IHABP4_N	320..>407	CDD:465041	19/94 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..413		14/60 (23%)