|
Fly 4 QQKASLCPRLVDYMAIVGAHTTPPMPKGLQGLKAPPVQVPDLLRRYPPSDHADFPLPLDMVYFCQ 68
|:| .||||:||:.||||. .|....: .|.|:||||||..||.:||||.|:|:|||
Rat 3 QKK--FCPRLLDYLVIVGAR--HPSSDSV-------AQTPELLRRYPLEDHPEFPLPPDVVFFCQ 56
Fly 69 PEGCTSVGPRRTGSAIRDMTSFVFALTDKDSGKTRYGICVNFYRPIER--PSSAAGSAGAGNDRP 131
||||.||..|| .::||.|||||.|||||:|.|||||||||||..:: |...
Rat 57 PEGCLSVRQRR--MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRMPKEK----------- 108
Fly 132 GNGGPGGHGGGAGGGAGGGGRGGRRSSAFRRESWRKSMERSSDSAFSSDYRSNVAPSDSDRELTS 196
|.||||..|:.|..:.....|:..:|.|..|.
Rat 109 -----------AEGGAGPRGKEGAHAPCASEEAATESSESGST---------------------- 140
Fly 197 RRDSDQQRLHSHHSHHQPHHPSASPAVPKLGLMAPSADSESGGSHSP-SPRASRKRTKLRNQSLT 260
|..|||||....:.|| ..|.::...:.||.:||
Rat 141 -------------------------------LQPPSADSTPDVNQSPRGKRRAKAGNRSRNSTLT 174
Fly 261 SLCIISHHPFFTTFRECLFILKKLIDACNESSSPKRVGASQKINRDNVWTVLTGH-VSDATPSIV 324
|||::||:|||:||||||:.||:|:|.|:|....|:.|..:.:.||.:|.:.||. :.:...|.:
Rat 175 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKPGIPRGVQRDTMWRIFTGSLLVEEKSSAL 239
Fly 325 LHDVREIETWILRLLSTPVPVPGSTRVEVEVLSPTVHEPLLFALPDHTRFSLVDFPLHLPLELLG 389
|||:||||.||.|||.:||||.|..||::|||...|.:.|.|||||.:||:||||||||||||||
Rat 240 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQEVQQALTFALPDPSRFTLVDFPLHLPLELLG 304
Fly 390 VETCLKVWTLIMQENKVLFQSRDYNALSMSVMAFVTMLYPLEYMFPVIPLLPTCLSCAEQLLLAP 454
|:.||:|.|.|:.|:||:.||||||||||||||||.|:||||||||||||||||::.||||||||
Rat 305 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAP 369
Fly 455 TPFVIGVPASFLVYKKNFRLPDDIWVVDLDSTKLTPPTGGYEEIPPLPEPEGTILKNHLKQAMLL 519
||::|||||||.:||.:|::|||:|:|||||.::..||.. |.:|.|||||...||.||||
Rat 370 TPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNA-EVLPILPEPESLELKKHLKQ---- 429
Fly 520 MDEAGLGALTSMTATNTAVSSQQLLPSVRDSLQEPPLLGVSQVRLPLQTPPHSAQASQRNSMSAQ 584
||.||:.....:.: |....:..:.|.||| |.|...|
Rat 430 -------ALASMSLNTQPILN---LEKFHEGQETPLLLG-------------------RFSNDLQ 465
Fly 585 GTISSRQPSPMNSPALNPFVYGTDVDSVDVATRVAMVRFFNAQNTLANFAEHTRTLRLYPRPVVA 649
.|.|:. .||.:||.||||||||||||||||||:.|.|..|..|||||||:||||||
Rat 466 STPSTE---------FNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVA 521
Fly 650 FQINSFLRSRPRASQFLNQFARTQAVEFLAEWSLTPTNVAFLRVQTGVMDPMQVGDKPKWFAHAL 714
||..|||.||||.:.|..:.|||||||:..||.|.|:|.||.|:.....||..:||||||:||.|
Rat 522 FQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIHNNTFDPALIGDKPKWYAHQL 586
Fly 715 TPIRFSVWDDGSSLNGALR--SLKQLECQPTDESGSDSEGADSSSSSYSSLSDFVSEMASSDLSP 777
.||.:.|:|..|.|..||. ..:..|..|||:|||||...|.||||||||.||||||...|::.
Rat 587 QPIHYRVYDSNSQLAEALSVPPERDSESDPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDING 651
Fly 778 SLHDVFGSYNRPHVVPQTLSSNLDPALVYHPPSKLQYPEGIADAVASKEEEDEERADS------- 835
:.|:|.|.|.::..|.: |...|.:..::|.:|...||
Rat 652 ---------DTPNVDPLTHAALGDAS------------EVEIDELQPQKEGEEPGPDSENSQENL 695
Fly 836 PVSSSSSRSDLSSPSFNRDSEFDFQPKGGQTLGSTTVGSGAAAPSFELATPLAMRLEATIKMASI 900
|:.||||.:..|||| |:..||.:
Rat 696 PLRSSSSTTASSSPS--------------------TIVHGAHS---------------------- 718
Fly 901 EQESDTVSTATGKTIAAGSKLQRHPSDSESRPEKKIPPPLTPPVKQPGVSNILARTGSSGSSSSS 965
:.:| ||..|...|.|. |:| .||:.|.:.:..|......|| ..|
Rat 719 -EPAD--STEVGDKAATGI----------SKP----LPPVPPSICKSTVDRRQTETG-----EGS 761
Fly 966 PGRQSSQSSLFE-NFASHAKELVRETTRQSSQEGLLAHVDKFTLHAKKAAGEASKQALEVSKQAA 1029
..:::.....|| .:.|.|:| ...::| .::..:|:.| |:|..:::.|
Rat 762 VCQRTYDHPYFEPQYGSPAEE-------DDDEQG-ESYTPRFSQH---ASGSRAQKLL------- 808
Fly 1030 GVSKNTLEDLTYVGKSTLGDLTKTAKEAATKKGIIKIEEHSAGGAGPPPKSPGSQLATHKQVQQS 1094
:...:|:...|...:.....||.|.::.: .:
Rat 809 ------------------------------RPNSLKLASDSDAESDSRASSPNSTVSNN----ST 839
Fly 1095 GGQGGGNNFFSAIGTDFNGLASSTSTMFS----GMFGKKSQQKQVPVQQKQPNVSAGKAKSGIN- 1154
.|.||..:|.|: |..:.||.|| .:..|.:::|..|. |::.. .|:|
Rat 840 EGFGGIMSFASS-------LYRNHSTSFSLSNLTLPTKGAREKTTPF----PSLKV----FGLNT 889
Fly 1155 -----FDPFPG-----RKGLV-ERTPLIKHSGPRQTQEELTRQQNQERSHSNAENQTFLKDVTNQ 1208
.:..|| |:.|| :::.:|||| |...:|. ...|.||.:::|||.|||:|.:.
Rat 890 LMEIVTEAGPGSGEGNRRALVDQKSSVIKHS-PTVKREP---PSPQGRSSNSSENQQFLKEVVHS 950
Fly 1209 VLAGEGVGWLKLNRFKKLMEDESYRTLVLSKLNKTLDKK-IAPDDHIDDVCVTKPVWKGMLKCIQ 1272
||.|:|||||.:.:.::|:|.|..|..|||||::.:..: .|..|.|.||.:::.|:||||..::
Rat 951 VLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLSRAVQSEDDARQDVIQDVEISRKVYKGMLDLLK 1015
Fly 1273 AIAGGLDVTFANFGLGGMASVFQLMEVAHTHYWSKEINEGSDMSSSLLSSHAASPMGSRENL--- 1334
.....|:.::|:.|||||||:|.|:|:|.|||:||| .|......:.:..:|:|....|
Rat 1016 CTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKE----PDKRKRSPTENVNTPVGKDPGLAGR 1076
Fly 1335 ----------------RSPSSPNGSHSALGSE-------------WASPQESRKSST-------- 1362
|:||:.......|.:. |...||.:|...
Rat 1077 GDPKAMAQLRVPQLGPRAPSATGRGPKELDTRSLKEENFVASVELWNKHQEVKKQKALEKQRPEV 1141
Fly 1363 -----QLAHGGPGGSHSGAPINRRLSSA------DSQDGQSTTEMFKDMLSQKRSALKNMLTSFD 1416
.|.......|...|.....|:|| ||..|.|...|.: |..:.:..:.:.|..
Rat 1142 IKPVFDLGETEEKKSQISADSGVSLASASQRTDQDSVIGVSPAVMIR---SSSQDSEVSTVVSNS 1203
Fly 1417 SDTTTSKDSKKS-----------SGNLWSGKSTLSAGFRYTG---------GHLINTSSSPSPD- 1460
|..|...||..| |.:|.|.::|||.....|. .|.:.....|:..
Rat 1204 SGETLGADSDLSSNAGDGPGGEGSAHLASSRATLSDSEIETNSATSTIFGKAHSLKPKEKPASSP 1268
Fly 1461 -------SPRVYLFEGLLGKD---------------------RLNLWNQMQFWEDAFLDAVSQER 1497
|.||||:|||||:| |..||:|||||||||||||..||
Rat 1269 VRSSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLER 1333
Fly 1498 DMIGMDQGPIEMMERYKSLSESERKRLEHDEDRLLSTMLYNLTAILVMLNVAKDEIRRKIRRLLG 1562
:.:||||||.||::||.||.|.:|||||.||||||:|:|:||.:.::::.|.|::||:|:|||:|
Rat 1334 EGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMG 1398
Fly 1563 KSHIGLVYSQEVHNVVDQINNLNGNDIDLKPLGSRLLHRQSFTVHQGTDVNGPLRFMEVRDDGLV 1627
|||:||||||:::.|:||:.||||.|:.::..|||.:.:|:|.||.|||.||.:.||||.||.:|
Rat 1399 KSHVGLVYSQQINEVLDQLTNLNGRDLSIRSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVV 1463
Fly 1628 LRSVDGTIVERWWYERLVNMTYSPKTKLLCLWRRNGGQTQLHKYYTRKCKELYNCIKEAMERGGT 1692
|||..||:.||||||:|:||||.||||:||||||||.:|||:|:||:||:|||.|:|::|||...
Rat 1464 LRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAA 1528
Fly 1693 PTNV----PELGGEFPVQDMNTGEGGLLQVCLEGVGLLFSNSKFFVRLDHIRKCFTQKGGIFVLE 1753
.... ||||||||||||.|||||||||.|||:.|.|.:::.|:.|:||:||.|.: |:||||
Rat 1529 RQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVR-GVFVLE 1592
Fly 1754 EYNPKT 1759
|:...|
Rat 1593 EFGNYT 1598
| 
