DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5347 and Mkrn3

DIOPT Version :9

Sequence 1:	NP_572970.1	Gene:	CG5347 / 32403	FlyBaseID:	FBgn0030578	Length:	285	Species:	Drosophila melanogaster
Sequence 2:	XP_038956927.1	Gene:	Mkrn3 / 292988	RGDID:	1311197	Length:	528	Species:	Rattus norvegicus

Alignment Length:	347	Identity:	129/347 - (37%)
Similarity:	171/347 - (49%)	Gaps:	86/347 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QTICRFHLLGICRFGDLCRFSHD-------------------------------------ETTPN 34
            |.:||::|.|.|:.||.||:|||                                     |..|.
  Rat    95 QILCRYYLHGQCKEGDNCRYSHDLSGRRKARGGQDSQPRASADRGPKMATHWEPPTQEVAEAPPT 159

  Fly    35 DNQS--PQISEIAD------EV-----------------VENEQVVASTSSYSRQMTWANAPEFV 74
            .:.|  |.|...|:      |:                 ::|..:.|..:..:....|..|.|||
  Rat   160 ASSSSLPLIGSAAERGFSEAEIDNAGIGSAAERGFPEAEIDNAGLAAGAAGGAGAEGWEGAIEFV 224

  Fly    75 P--RYKAN-------SADFQATEGVQD-----------ICPYG--GSCIWGSKCSYPLHMEICKM 117
            |  .|:..       .|..|:.|..::           :|.|.  |.|:.|.:|:|| |.|||.|
  Rat   225 PGQPYRGRMIPPHGPEAPLQSPEIEREHMAMGMGMPLPLCRYAARGQCLRGDRCAYP-HGEICDM 288

  Fly   118 CDLYCLHPMDQNQRRAHNRECLEQHEQAMELSFAIARSKDKMCGICFDTVVEKKG-RERRFGILS 181
            |....|||.|..|:.||.|.|:|.||:.||||||:.||.||:||||.:.|.||.. .:||||||.
  Rat   289 CGQQALHPWDAAQQEAHRRACVEAHERDMELSFAVQRSMDKVCGICMEVVYEKADPSDRRFGILF 353

  Fly   182 KCKHIFCLTCIRTWRQAHQFEATVTRGCPECRVFSEFVCPSAYWVDTKEEKDKLLSEYRAAMGAK 246
            .|.|.:||.|||.||.|.|||..:::.||:|||.|.||.||.:||:.:|||:||:.:|:..|..|
  Rat   354 SCNHTYCLKCIRRWRSATQFENRISKSCPQCRVSSGFVIPSEFWVEEEEEKEKLVQQYKEGMSQK 418

  Fly   247 DCKYFNGGLGKCPFGNKCFYRH 268
            .|:||.||||.||||..|||:|
  Rat   419 ACRYFAGGLGHCPFGEFCFYKH 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5347	NP_572970.1	ZnF_C3H1	4..30	CDD:214632	13/59 (22%)
		PHA03096	<80..239	CDD:222981	82/179 (46%)
		RING	159..213	CDD:238093	28/54 (52%)
Mkrn3	XP_038956927.1	zf-CCCH_4	96..117	CDD:407881	10/20 (50%)
		PHA03096	<272..420	CDD:222981	79/148 (53%)
		RING-HC_MKRN1_3	328..388	CDD:319644	33/59 (56%)
		MKRN1_C	442..528	CDD:406294
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I7980
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3107
OMA	1	1.010	-	-		QHG58455
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	1	1.000	-	-		mtm9084
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X837
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080