DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5321 and BBOX1

DIOPT Version :9

Sequence 1:	NP_001285244.1	Gene:	CG5321 / 32399	FlyBaseID:	FBgn0030575	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_001363187.1	Gene:	BBOX1 / 8424	HGNCID:	964	Length:	387	Species:	Homo sapiens

Alignment Length:	362	Identity:	143/362 - (39%)
Similarity:	208/362 - (57%)	Gaps:	9/362 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 FPGIWLRDNCMCEDCFHGSSKSRKLDWDNFDTRIRPVSLQTDEQSKEVLVKWSDAHESRFSLKWL 113
            :|.:||||||.|.||:..|:|:|||..:..|..|....|..|.  |:|.:.|.|.|.|.|...||
Human    29 YPAVWLRDNCPCSDCYLDSAKARKLLVEALDVNIGIKGLIFDR--KKVYITWPDEHYSEFQADWL 91

  Fly   114 KERCFEPDKQQEYLRDFYRPTTRHWSGAEFQDIAQHFSYDEVMSQDSVLMQWLQALAIYGVALLR 178
            |:|||....:.:..|:.:.|..::| |:|.|  .....:::|:..|....:||..|...|:..|.
Human    92 KKRCFSKQARAKLQRELFFPECQYW-GSELQ--LPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLT 153

  Fly   179 GAPLDEGVVRRLADRVGFIRRTTYGEEFVVQAKPGAQNFAYLSLTLPLHTDLPYYEYKPSVNILH 243
            ||....|.|.:|..|:||:..|.||..:.||.|..|.|.||.:..|..|||.|...:.|.|.:||
Human   154 GASDKPGEVSKLGKRMGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLH 218

  Fly   244 CVVQTDSPGGSNMLVDGFHVADLLRRDHPEDFERLSRIVVDWNDIGSEDGREFHNIWRAPVICLD 308
            |:.||.: ||.:.:||||:|...|::::|:.|:.||...||:.||| .|..:|....:..:|.||
Human   219 CIKQTVT-GGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIG-VDYCDFSVQSKHKIIELD 281

  Fly   309 EEGRYTRINHSVPQRDSHFNVPLEEVLPWYESYALFVRL--AIADSHAFKTRPGDVLTFNNIRLL 371
            ::|:..|||.:...||:.|:||:|.|.|:|.:...||.|  :......||..||||:||:|.|||
Human   282 DKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLL 346

  Fly   372 HGRTGYDDSEESPRYIVGAYLDWDIIYSRLRVLKKRL 408
            |||..|:...|..|::.|||.|||::.||||:|::|:
Human   347 HGRRSYEAGTEISRHLEGAYADWDVVMSRLRILRQRV 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5321	NP_001285244.1	DUF971	<48..113	CDD:294847	26/63 (41%)
		carnitine_bodg	49..405	CDD:274118	141/357 (39%)
		CAS_like	127..395	CDD:238154	103/269 (38%)
BBOX1	NP_001363187.1	carnitine_bodg	16..381	CDD:274118	142/358 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152942
Domainoid	1	1.000	167	1.000	Domainoid score	I3861
eggNOG	1	0.900	-	-		E1_COG2175
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2967
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3116
Isobase	1	0.950	-	0.909372	Normalized mean entropy	S3503
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D534559at33208
OrthoFinder	1	1.000	-	-		FOG0003526
OrthoInspector	1	1.000	-	-		otm41552
orthoMCL	1	0.900	-	-		OOG6_102379
Panther	1	1.100	-	-	LDO	PTHR10696
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2023
SonicParanoid	1	1.000	-	-		X2892
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740