Protein Alignment Tat and KYAT1

DIOPT Version :10

• Sequence 1: NP_572953.1
• Gene: Tat / 32381
• FlyBaseID: FBgn0030558
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001274319.1
• Gene: KYAT1 / 883
• HGNCID: 1564
• Length: 516
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 117/517 - (22%)
• Similarity: 210/517 - (40%)
• Gaps: 121/517 - (23%)

  Fly    27 PSEPESPAPVTPNCDVVDQALAELQLQSQDIRKQQDLVDTTATSSSSRKRSG-----WEIKGSKL 86
            |..|:||..|.....::....|:|.:|....:.      ..|....:|:..|     |
Human    61 PQGPQSPCEVPAAEGILRTGGAKLPIQGHPAKL------AMAKQLQARRLDGIDYNPW------- 112

  Fly    87 SLNTHNRIRNIVESLKIKPNPEKPMIPLSIGDPTTFGNLKAADETMKAVLHSLESGKY--NGYAS 149
                       ||.:|:.  .|..::.|..|    |.:....|..::|..|:: ||.:  |.|..
Human   113 -----------VEFVKLA--SEHDVVNLGQG----FPDFPPPDFAVEAFQHAV-SGDFMLNQYTK 159

  Fly   150 TQGHEIARKAVAKYSAHQRPDGEIDANE------VVLCSGCSSALEYCILALADRGQNVLVPRPG 208
            |.|:....|.:|.:.      ||:...|      |::..|...||.....||.|.|..|::..|.
Human   160 TFGYPPLTKILASFF------GELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPF 218

  Fly   209 FCLY---YTLAQGLDI-------EVRYYDLLPDQQWRADLVQLESLIDENTAALLINNPSNPCGS 263
            |..|   ..:|.|..:       .::..:|.....|:.|.::|.......|.||::|.|:||.|.
Human   219 FDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGK 283

  Fly   264 VFDEKHLRELIAICERHYLPIIADEIYEHFVFPGSKHLAVSSLTTEVP-----VLSCGGLTKRFL 323
            ||..:.|..:.::|::|.:..|.||:|:..|:.|.:|::::||    |     .|:.|...|.|.
Human   284 VFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASL----PGMWERTLTIGSAGKTFS 344

  Fly   324 VPGWRMGWIIVHDRKNRLRDAIVGLKNMCGRILGSNTII------QGALPD------ILTKTPQS 376
            ..||::||::..|..         :|::  |.:..|::.      |.|:.:      :|.:.|.|
Human   345 ATGWKVGWVLGPDHI---------MKHL--RTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSS 398

  Fly   377 YFDGVIDVLHSNAMLAYK--MLKQVR--GLDPVMPNGAMYMMIGVS--IERFPEFKD------DT 429
            ||     |....||...:  |::.::  ||.|::|.|:.:::..:|  ..:.|:...      |.
Human   399 YF-----VQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDR 458

  Fly   430 HFVQEMVNEQSVFCLPGSCF-------EYPGYVRIVLTVPGAMIEEACSRIAEFCDRHYKKE 484
            .||:.|:..:.:..:|.|.|       .:..|:|.......|.::....::     |.:|.|
Human   459 RFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKL-----RKWKVE 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tat	NP_572953.1	tyr_amTase_E	79..481	CDD:273529	104/455 (23%)
KYAT1	NP_001274319.1	AspB	101..512	CDD:440205	106/466 (23%)