Protein Alignment inaE and Dagla

DIOPT Version :10

• Sequence 1: NP_001138195.1
• Gene: inaE / 32343
• FlyBaseID: FBgn0261244
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: NP_001005886.1
• Gene: Dagla / 309207
• RGDID: 1359461
• Length: 1044
• Species: Rattus norvegicus
• Alignment Length: 1133
• Identity: 382/1133 - (33%)
• Similarity: 566/1133 - (49%)
• Gaps: 173/1133 - (15%)

  Fly     1 MPGLVVFRRRWSVGSDDLVVPGAFLLTIHFICFVIVSVSLVIFEYNTRILSVKLLFYHLIGYLLI 65
            |||:|||||||||||||||:|..||..:|...|||:||.|....||........|..|..|||.|
  Rat     1 MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGRGYLGI 65

  Fly    66 LFFSICVEIGICVISMRGSILDAEARTSINIWIYLKSLVILFDIAWLAVGSVWLGHYYTTAPIDD 130
            |...:..|:.|..:||||.||..|.|.|:...:|::..:::.:..:..||.|||..|||:.....
  Rat    66 LLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLTQYYTSCNDLT 130

  Fly   131 PKKVYIAIIICNWALVVITLITIWCTFDAAGRSWVKMKKYQRSMRETESRFNYKRSNSMNRNWRQ 195
            .|.|.:.:::|||.:::...||:.|.||..||::||::..:|..|           |....|.|.
  Rat   131 AKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQR-----------NLRTYNLRH 184

  Fly   196 RKVMRAYQDSWDHRCRLLFCCMGSSERNRNSFTDIARLLSDFFRELDVVPSDVVAGLVLLRKFQR 260
            | :......||..|.::..||..:.:...:::::||.|.::|||:||:||||::|||||||:.||
  Rat   185 R-LEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGLVLLRQRQR 248

  Fly   261 LEREAIVRQRKNGTYEFLSGVPITERTQFLALNDAKNYDFFQTVIHYMYFAQGAYGWPMYVIINR 325
            .:|.|::.:..|....||||:|:|..|::|.|.::.....::.|.:||.||..|||||||::  |
  Rat   249 AKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSHEMLRYKEVCYYMLFALAAYGWPMYLM--R 311

  Fly   326 SKMWHLVPELKCFGCC-CGT----SDDTEVIQDNCCLCNYAALKKTL---QLGDIDIVYATYHVD 382
            .....|....:...|| |..    :....:.:||||.||..|:::..   .:..:||||.:.|..
  Rat   312 KPTCGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDA 376

  Fly   383 VGETPFFVAIDYTHRAVVISIRGTLSMKDILTDLNAEGEVLPLQPPRDDWLGHKGMVQAAIYIRN 447
            |.||||:||:|:..:.||||||||||.||.||||..:.|.||::..|..||||||||.:|.||:.
  Rat   377 VYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVEGHRGTWLGHKGMVLSAEYIKK 441

  Fly   448 KLQEENLIERALQRNPDRQTHTFDLVLVGHSLGAGTAAILAILLKPEHPTLQCFSYSPPGGLLSM 512
            ||::|.::.:|..|:..|.|..:.|::|||||||||||||:.||:|::|||:||:|||||||||.
  Rat   442 KLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSE 506

  Fly   513 PAVEYSKSFITSVVLGKDVVPRIGLNQMEALRADLINAIQRSVDPKWKTISCSVICCGCGPEPTS 577
            .|:||||.|:|:||||||:||||||:|:|..|..|::.:|||..|||:.|..:..|......|..
  Rat   507 DAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKSELPED 571

  Fly   578 VVNMSGQDTHINQYQEERGTARSTS---AHPTDSSIALTLHQPLYPPGRIIHIVRHHPKPD---- 635
            .|.:               ||.:::   .||:|.:|||:...||||||||||:|.:||...
  Rat   572 QVEV---------------TALASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCC 621

  Fly   636 EQKYDSGWRNVLKNREPVYQAIWADSTDFDEVLISPVMLQDHMPDKVLAALKKVVTTSGPRKPQR 700
            ||:            ||.|.|||.|:..|:||:|||.||.:|:|..|:..|.||:
  Rat   622 EQE------------EPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVL---------- 664

  Fly   701 QTSNAFSTGSNEAAH------DMDLEP-------PHCSGHSAPTDAMRFETRTDPGQMQNSMSQS 752
            :..|...|....||.      ::||.|       |..:|...|| .:..|......:..:..|:|
  Rat   665 ENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPLPT-GLALELPATEHRNSSVRSKS 728

  Fly   753 QHCKRLSQSSYTNLSNCLVLTPTA-----------------QHKLCLETSFTNGSTPHQSGVQPN 800
            |     |:.|....|...:|:|.|                 |.:|..|..              :
  Rat   729 Q-----SEMSLEGFSEGRLLSPVAAASAARQDPVELLLLSTQERLAAELQ--------------S 774

  Fly   801 PRLTSAASSLLSSATTPYDISSALDDSLATVALRQSPSL---ISAETTATVIVNPEPDAEEIAIP 862
            .|...|....||...:.|...|.......::  |.||||   :..:......::|....|..::.
  Rat   775 RRAPLATMESLSDTESLYSFDSRRSSGFRSI--RGSPSLHAVLERDEGHLFYIDPAIPEENPSLS 837

  Fly   863 QRLKAVAFD-MALTPPPTLPERSMLGRQH-SEKKPRSLPLAQVQALRRASDAGAVPGVDL-LHDD 924
            .|.:.:|.| ::.....|.|..:.||... :.::|.|....:.:|...:...|..|..:| ||:.
  Rat   838 SRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSAANDEEEAAGGSEGGGVAPRGELALHNG 902

  Fly   925 WYGLAPLASPETL------SEISSVSSRTS---------VPISLANSIERYLQHMGVGVGGPKVP 974
            ..|.:|  ||:.|      ..:.::.|::|         ||.|..:.   |.:       |||.|
  Rat   903 RLGDSP--SPQVLEFAEFIDSLFNLDSKSSSFQDLYCMMVPESPTSD---YTE-------GPKSP 955

  Fly   975 --LEDIFESQLHTPKVMRRAPKFSENLAGCAEDTRNLDQYKRLGRVFITFPRIFPDQSPAAHSLD 1037
              .|.:..:|.. |.::.:.|:.   .||.||.:..           |:....|| .|.:...:|
  Rat   956 SQQEILLRAQFE-PNLVPKPPRL---FAGSAEPSSG-----------ISLSPSFP-LSSSGELMD 1004

  Fly  1038 SSDDSFESASAHSLQRLQLP----HGAN 1061
            .:.....|....:..:::..    |||:
  Rat  1005 LTPTGLSSQECLATDKIRTSTPTGHGAS 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaE	NP_001138195.1	Lipase_3	300..542	CDD:238287	126/249 (51%)
Dagla	NP_001005886.1	Lipase_3	288..529	CDD:238287	121/242 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	848..905		12/56 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1013..1044		3/20 (15%)