Protein Alignment CtsB and Ctsr

DIOPT Version :10

• Sequence 1: NP_572920.1
• Gene: CtsB / 32341
• FlyBaseID: FBgn0030521
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_064680.1
• Gene: Ctsr / 56835
• MGIID: 1861723
• Length: 334
• Species: Mus musculus
• Alignment Length: 329
• Identity: 89/329 - (27%)
• Similarity: 137/329 - (41%)
• Gaps: 77/329 - (23%)

  Fly    26 DEFIEVVRSKAKTWTVGRN-FDASV------TEGHIRRLM-----GVHPDAHKFALPDKREVLGD 78
            :|.:::::...:..::|:| |...:      |:...|::|     ..|.:.....   |||. |.
Mouse    53 EEKLKMIKLHNRENSLGKNGFTMKMNEFGDQTDEEFRKMMIEISVWTHREGKSIM---KREA-GS 113

  Fly    79 LYVNSVDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAF---GAVEAMSDRVCIHSGGKVNFHF 140
            :       ||:..|.||:....|    :|.||.|.:||||   ||:||.:    |...||:. ..
Mouse   114 I-------LPKFVDWRKKGYVTP----VRRQGDCDACWAFAVTGAIEAQA----IWQTGKLT-PL 162

  Fly   141 SADDLVSCCHTCG-FGCNGGFPGAAWSYWTRK-GIVSGGPYGSNQGCRPYEISPCEHHVNGTRPP 203
            |..:||.|....| .||.||....|:.|.... |:.|...|       |||         |...|
Mouse   163 SVQNLVDCSKPQGNNGCLGGDTYNAFQYVLHNGGLESEATY-------PYE---------GKDGP 211

  Fly   204 CAHGGRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPV-EGAFTVYEDLIL 267
            |.:   .||.|....:|:.              |:.::...:...:.|.||: .|....:|....
Mouse   212 CRY---NPKNSKAEITGFV--------------SLPQSEDILMAAVATIGPITAGIDASHESFKN 259

  Fly   268 YKDGVYQHEH--GKELGGHAIRILGWGVWGEEK--IPYWLIGNSWNTDWGDHGFFRILRGQ-DHC 327
            ||.|:| ||.  ..:...|.:.::|:|..|.|.  ..||||.|||...||..|:.::.:.: :||
Mouse   260 YKGGIY-HEPNCSSDTVTHGVLVVGYGFKGIETDGNHYWLIKNSWGKRWGIRGYMKLAKDKNNHC 323

  Fly   328 GIES 331
            ||.|
Mouse   324 GIAS 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsB	NP_572920.1	Propeptide_C1	24..64	CDD:462365	8/49 (16%)
		Peptidase_C1A_CathepsinB	88..336	CDD:239111	76/255 (30%)
Ctsr	NP_064680.1	Inhibitor_I29	29..87	CDD:214853	5/33 (15%)
		Peptidase_C1A	116..332	CDD:239068	76/255 (30%)