DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and cpr-6

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_741818.1	Gene:	cpr-6 / 180931	WormBaseID:	WBGene00000786	Length:	379	Species:	Caenorhabditis elegans

Alignment Length:	336	Identity:	168/336 - (50%)
Similarity:	211/336 - (62%)	Gaps:	21/336 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LTSGEPSLLSDEFIEVVRSKAKTWTV--GRNFDASVTEGHIRR--LMGVHPDAHKFALPDKREVL 76
            :.|....|..|:.|:.|......||.  .|.|.:...|....:  ||||:   |.     :..|.
Worm    34 IDSEAAELDGDDLIDYVNENQNLWTAKKQRRFSSVYGENDKAKWGLMGVN---HV-----RLSVK 90

  Fly    77 GDLYVNSVDEL----PEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVN 137
            |..:::...:|    ||.||||..||.|.:|..||||.|||||||||||||||||:||.|.|::.
Worm    91 GKQHLSKTKDLDLDIPESFDSRDNWPKCDSIKVIRDQSSCGSCWAFGAVEAMSDRICIASHGELQ 155

  Fly   138 FHFSADDLVSCCHTCGFGCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTR- 201
            ...|||||:|||.:||||||||.|.|||.||.:.|||:|..|.:|.||:||...|||||...|.
Worm   156 VTLSADDLLSCCKSCGFGCNGGDPLAAWRYWVKDGIVTGSNYTANNGCKPYPFPPCEHHSKKTHF 220

  Fly   202 PPCAHG-GRTPKCSHVCQSGYT-VDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYED 264
            .||.|. ..||||...|.|.|| ..|::||.||:.:|.|:.:|..||:|:||:||:|.||.||||
Worm   221 DPCPHDLYPTPKCEKKCVSDYTDKTYSEDKFFGASAYGVKDDVEAIQKELMTHGPLEIAFEVYED 285

  Fly   265 LILYKDGVYQHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDHCGI 329
            .:.|..|||.|..||..||||::::|||:  ::.||||.:.||||||||:.||||||||.|.|||
Worm   286 FLNYDGGVYVHTGGKLGGGHAVKLIGWGI--DDGIPYWTVANSWNTDWGEDGFFRILRGVDECGI 348

  Fly   330 ESSISAGLPKL 340
            ||.:..|:|||
Worm   349 ESGVVGGIPKL 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	12/43 (28%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	146/250 (58%)
cpr-6	NP_741818.1	Propeptide_C1	44..82	CDD:369701	10/37 (27%)
cpr-6	NP_741818.1	Peptidase_C1A_CathepsinB	106..355	CDD:239111	146/250 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	320	1.000	Domainoid score	I663
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	331	1.000	Inparanoid score	I1432
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D439739at33208
OrthoFinder	1	1.000	-	-		FOG0001215
OrthoInspector	1	1.000	-	-		otm14118
orthoMCL	1	0.900	-	-		OOG6_101151
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1059
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980