DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ndc80 and Ndc80

DIOPT Version :9

Sequence 1:	NP_572902.1	Gene:	Ndc80 / 32316	FlyBaseID:	FBgn0030500	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_075783.2	Gene:	Ndc80 / 67052	MGIID:	1914302	Length:	642	Species:	Mus musculus

Alignment Length:	701	Identity:	142/701 - (20%)
Similarity:	283/701 - (40%)	Gaps:	166/701 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LEERGTAD---------KRQTRATKRSAATHTPSSSQAAP---RRPSASRLPQPLNLERDRASQM 69
            ::|..|.|         :.:.|:|....:||.|:|.:...   :|.|.         ...|.||:
Mouse    16 MQELRTLDLNKPGLYTPQTKERSTFGKLSTHKPTSERKVSIFGKRTSG---------HGSRNSQL 71

  Fly    70 GVTPKRGHRFVPSTAERAIAPHSDKKWVAERAQQILEYLHGIQNSEAPTGLIADLFSRPGGLRHM 134
            |:       |..|...:...|.:||.::.:..:|:.|:|       ...|.:..:..:  .|:..
Mouse    72 GI-------FSSSEKIKDPRPLNDKAFIQQCIRQLYEFL-------TENGYVYSVSMK--SLQAP 120

  Fly   135 TIKQFVSILNFMFHHIWRNRVTVGQNHVEDITSAMQKLQYPYQVNKSWLVSPTTQHSFGHVIVLL 199
            :.|:|:.|..|::..:..:....|....|::....:.|.||:.::||.:.:....|::.|::..|
Mouse   121 STKEFLKIFAFLYGFLCPSYELPGTKCEEEVPRIFKALGYPFTLSKSSMYTVGAPHTWPHIVAAL 185

  Fly   200 DFLMDFLPPLPSSDVVEEEFPFMETMEQPSSYLNSMHCESTTIMSTTQAHAIQLDEDV--NGLLF 262
            .:|:|.:.                        :::...||:.:....|....:.::.:  |.|..
Mouse   186 VWLIDCIK------------------------IDTAMKESSPLFDDGQLWGEETEDGIKHNKLFL 226

  Fly   263 EEASKCIALWDQELT------NEEAKLQAETRD--QVISKKCDL--PDRKALDQLIGDLKTKLQQ 317
            |...||   :::.:|      .|:|:|||:.:|  :|.:.|.:.  .:.|||::.|..|:.:.::
Mouse   227 EYTKKC---YEKFMTGADSFEEEDAELQAKLKDLYKVDASKLESLEAENKALNEQIARLEEERER 288

  Fly   318 LENKLHDPSEDNKLNKLERLTKEHDQLAQQLAASEEELIKKLKLYEQLSAQVEEKQSNLRQQMKY 382
                     |.|:|..|::|........|...|....|...|.:.:|.|..::|:...:.|:.:.
Mouse   289 ---------EPNRLMSLKKLKASLQADVQNYKAYMSNLESHLAVLKQKSNSLDEEIGRVEQECET 344

  Fly   383 EK----RLEQAVNRQKFSAQQLKELQMKCDDMENYSKAYERQV--KEVSELELHQQVM----LSR 437
            .|    ||:..|:.||:|...::.:        |:.|...:|.  |...:||..||.|    |..
Mouse   345 VKQENTRLQSIVDNQKYSVADIERI--------NHEKNELQQTINKLTKDLEAEQQQMWNEELKY 401

  Fly   438 AKQKQLDSVEVFNSH--VRHLSMDPVICGLIKSGIGQQS-DLTLPLNPNQED---ISERVQCLEL 496
            |:.|:....::...|  .|.|.:.|      |.....:. |..:..||....   :..|.|....
Mouse   402 ARGKEAIEAQLAEYHKLARKLKLIP------KGAENSKGYDFEIKFNPEAGANCLVKYRTQVYAP 460

  Fly   497 LGKLLQQHRQQNIDRRQMLDKQVAKVK--SDSIELDTEIATMDSQLRAQKQRLTKMEASYRTKRD 559
            |.:||.:..::       ::|.:.|.:  .|::|   ::.||.::.: ...|:.|.|.
Mouse   461 LKELLNESEEE-------INKALNKKRHLEDTLE---QLNTMKTESK-NTVRMLKEEI------- 507

  Fly   560 MQAQHRQQLLEDQYDQTARLDELEKREKQALEKLEASKQRNEDLLTAAEQFQEQDLKARQDRLEK 624
                   |.|:|.:.|..:  |.|:::|::..:|| |.::::.||.:.
Mouse   508 -------QKLDDLHQQAVK--EAEEKDKKSASELE-SLEKHKHLLESG----------------- 545

  Fly   625 CEQKLAKAEDQLLAVESKVNATQAKLNEVEQKVYSAKLPSFQPVLDAIKNH 675
            ....|::|.|:|.||:.:...|.....|..:||.:    :.|.:|:.:..|
Mouse   546 VNDGLSEAMDELDAVQREYQLTVKTTTEERRKVEN----NLQRLLEMVATH 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndc80	NP_572902.1	Ndc80_HEC	63..204	CDD:281754	29/140 (21%)
Ndc80	NP_075783.2	Interaction with the N-terminus of CDCA1. /evidence=ECO:0000250	1..445		95/462 (21%)
		Nuclear localization. /evidence=ECO:0000250	1..250		44/245 (18%)
		HEC1	48..619	CDD:227512	120/600 (20%)
		Ndc80_HEC	51..205	CDD:281754	30/153 (20%)
		Interaction with RB1. /evidence=ECO:0000250	128..251		20/122 (16%)
		Interaction with NEK2 and ZWINT. /evidence=ECO:0000250	251..618		85/396 (21%)
		Interaction with SMC1A. /evidence=ECO:0000250	251..431		45/197 (23%)
		DUF342	<324..394	CDD:302792	18/73 (25%)
		Interaction with PSMC2 and SMC1A. /evidence=ECO:0000250	361..547		43/203 (21%)
		Interaction with the C-terminus of CDCA1 and the SPBC24-SPBC25 subcomplex. /evidence=ECO:0000250	446..642		40/203 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5185
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	76	1.000	Inparanoid score	I5246
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55244
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10643
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.970