Protein Alignment HDAC4 and HOS3

DIOPT Version :9

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: NP_015209.1
• Gene: HOS3 / 855987
• SGDID: S000006037
• Length: 697
• Species: Saccharomyces cerevisiae
• Alignment Length: 502
• Identity: 106/502 - (21%)
• Similarity: 172/502 - (34%)
• Gaps: 180/502 - (35%)

  Fly   759 PLSR--------TLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPP-------VNLSLPHR 808
            ||.|        ..::|.|.......:|||::. :...:.:..|..|:.|       ...::..|
Yeast     8 PLERFYKQFQAFVQNNPNVISAARAAAQIPESA-KAVVVLSPYSLQHVFPREWVTKSYRKTIVER 71

  Fly   809 QHRQLMS--------TLYASQL---RNHQPSASGSPPHKVTTGLAYDPLMLK-HSCICGDNAQHP 861
            ..|.|.|        |:|.|..   .:||...|...||           :|| |.
Yeast    72 PERLLASSMGISAAITMYPSLFTLKSSHQRKGSLMAPH-----------VLKVHG---------- 115

  Fly   862 EHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSA 926
                   |.|    ..:|::.|....|:                :|.|.
Yeast   116 -------SSW----PAELIELCQMADAK----------------LLKGE---------------- 137

  Fly   927 SFVRLSCGGLGVDLDTTWN------EHHTATAARMAAGCV---IDLALK--TAKGDLRNGFAVVR 980
                       :::..|||      ...|..|.:...|.:   :|...|  :|:......|..:|
Yeast   138 -----------IEVPDTWNSGDIYLSSKTIKALQGTIGAIETGVDSIFKGPSAEHISNRAFVAIR 191

  Fly   981 PPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQ-------------- 1031
            |||||.......|||..|:..:|.:...... .|..::::|:|:|||:|||
Yeast   192 PPGHHCHYGTPSGFCLLNNAHVAIEYAYDTY-NVTHVVVLDFDLHHGDGTQDICWKRAGFKPEEE 255

  Fly  1032 ----------QAFYQSPDILYLSIHRHDDGNFFPGTGG---------PTECGSGAGLGFNVNISW 1077
                      :.|.:.|.:.|.|:|   |.|.||...|         .:.|...:   .::|| |
Yeast   256 PEDSSYDDFGKKFAEFPKVGYFSMH---DINSFPTESGFATKENIKNASTCIMNS---HDLNI-W 313

  Fly  1078 SGALNPPLGDAEYIAAFRTVVMPI------------------ARSFNPDIVLVSSGFDAATGHPA 1124
            :..|:....:.|:...:||....:                  .|.|. .:|::|:||||:.....
Yeast   314 NIHLSKWTTEEEFNVLYRTKYRTLFAKADEFFRSAKLEMNQQGRPFK-GLVVISAGFDASEFEQT 377

  Fly  1125 PLGGYHVS-PACF-GFMTRELLQLA----NGKVVLALEGGYDLAAIC 1165
            .:..:.|: |..| ...|::.|:||    :|||:..:||||...|||
Yeast   378 SMQRHSVNVPTSFYTTFTKDALKLAQMHCHGKVLSLMEGGYSDKAIC 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
		HDAC_classIIa	837..1211	CDD:212544	83/398 (21%)
HOS3	NP_015209.1	HDAC_Hos3	47..435	CDD:212522	98/462 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344912
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740