DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and HD1

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_195526.1	Gene:	HD1 / 829969	AraportID:	AT4G38130	Length:	501	Species:	Arabidopsis thaliana

Alignment Length:	485	Identity:	113/485 - (23%)
Similarity:	186/485 - (38%)	Gaps:	113/485 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   829 ASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQ 893
            |||....|......|||.:..:....|    ||....|::...|.|....|::....|:...|..
plant     9 ASGPDGVKRKVCYFYDPEVGNYYYGQG----HPMKPHRIRMTHALLAHYGLLQHMQVLKPFPARD 69

  Fly   894 EELQTVHTEAHAMLFGS-----NQCQLSRPKLENTLS--------ASFVRLSCGGLGVDLDTTWN 945
            .:|...|.:.:.....|     .|.|:.:.|..|...        .||.:...||
plant    70 RDLCRFHADDYVSFLRSITPETQQDQIRQLKRFNVGEDCPVFDGLYSFCQTYAGG---------- 124

  Fly   946 EHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIA-AKLLRQ 1009
              ....:.::..| :.|:|:..|.|            .|||:...|.|||:.|.|.:| .:||:|
plant   125 --SVGGSVKLNHG-LCDIAINWAGG------------LHHAKKCEASGFCYVNDIVLAILELLKQ 174

  Fly  1010 RMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVN 1074
            .    .|:|.||.|:|||:|.::|||.:..::.:|.|:.  |::|||||...:.|.|:|..:::|
plant   175 H----ERVLYVDIDIHHGDGVEEAFYATDRVMTVSFHKF--GDYFPGTGHIQDIGYGSGKYYSLN 233

  Fly  1075 ISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVS----PAC 1135
            :    .|:..:.|..|...|:.::..:...|.|..|::..|.|:.:|.  .||.:::|    ..|
plant   234 V----PLDDGIDDESYHLLFKPIMGKVMEIFRPGAVVLQCGADSLSGD--RLGCFNLSIKGHAEC 292

  Fly  1136 FGFMTRELLQLANGKVVLALEGGYDLAAICDSAQEC----VRALLG------------------D 1178
            ..||     :..|..::|...|||.:..:.    .|    ....||                  |
plant   293 VKFM-----RSFNVPLLLLGGGGYTIRNVA----RCWCYETGVALGVEVEDKMPEHEYYEYFGPD 348

  Fly  1179 PAAPIAKAELE----RPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETI 1239
            ....:|.:.:|    |...:...|.|...::..| |.|.|...|..   ...||.:|:.|:.:..
plant   349 YTLHVAPSNMENKNSRQMLEEIRNDLLHNLSKLQ-HAPSVPFQERP---PDTETPEVDEDQEDGD 409

  Fly  1240 NAMAGLSMQSMHRTLSRDDSEEPMDQDETK 1269
                           .|.|.:..||.|:.:
plant   410 ---------------KRWDPDSDMDVDDDR 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	96/417 (23%)
HD1	NP_195526.1	Arginase_HDAC	17..395	CDD:418394	100/431 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810