Protein Alignment HDAC4 and hda-4

DIOPT Version :10

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: NP_001257278.1
• Gene: hda-4 / 181723
• WormBaseID: WBGene00001837
• Length: 869
• Species: Caenorhabditis elegans
• Alignment Length: 993
• Identity: 308/993 - (31%)
• Similarity: 454/993 - (45%)
• Gaps: 272/993 - (27%)

  Fly   363 SSPSLPNI------SLGRPHLPNSAQAHAQVNAQVAAQAQ---------AQAQAQAQ-AHAMFAA 411
            :.||:||:      ::|:.:|...:.|..|...|...|.|         ||.:...| .|.::||
 Worm    14 AGPSVPNLPSTSEAAIGQTNLEPESIALLQSQLQEYRQKQMDLIGHFQRAQQELSVQHMHNLYAA 78

  Fly   412 LAAAQGGCGQPGYYNPLGMAFVGRQPA-PLAMIPATGIAPQQPSPVVRSASATSTSSSQASLVGD 475
            |...|          .|......|... ||.:........|...|....:.|.|.::..:|..|:
 Worm    79 LQQQQ----------QLQNLQTERSAVNPLLISQQHSTEDQNSGPAAPLSLANSLTNLLSSSNGN 133

  Fly   476 VAPPQA-----HAASTI------LP-SSSSYMQQL-------------GSVAGSGVNLHAAAVAA 515
            ::.||.     |..:..      || |:|:.:.||             ...:.|..||.:.:|.|
 Worm   134 LSVPQTPTKEHHPTAPTSNRKCDLPRSNSTTISQLTKDRLKNMIANRSKGESNSQSNLMSNSVTA 198

  Fly   516 AAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQ 580
                                             :|:||.:|
 Worm   199 ---------------------------------NGNGHDNG------------------------ 206

  Fly   581 GHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHYE---------NSEAERQAYEHQVVNQKVRQTV 636
              |.|..:.|              |:||...|:|         |:...:||.|.|:........:
 Worm   207 --RKLKNSNS--------------QVNVSSPHFEPYRLPTSLANAHNLQQASEFQLRKVNSEPNL 255

  Fly   637 LTRSGAAAAAAAAAGVSVVRE---------AQLKEEDDDSAAEV----MDLTDKKKPPKTVLTST 688
            ..|..|...:..::.|..|::         .|||..|.:::..|    |..:.:...|..:|
 Worm   256 KMRIRAKLLSKGSSPVQHVQQNNSQFNFTHPQLKRSDSETSQNVPLDFMQSSSQTNLPHLML--- 317

  Fly   689 IATSTSQNLPEALAAAAA-----------AAAYRAPHNAS------------------------- 717
                .|.:||. ||||.|           ..|:.|..|.|
 Worm   318 ----PSPSLPN-LAAAGAFHGLNLPVGQDLNAFMAVANLSPFLSLPSLLNKKLELGGLTDEGDRN 377

  Fly   718 ----SNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELA---KSLMRPLSRTLSSPLVPLGPHG 775
                |:|.|:..|.:.:...:|      |.||.||..:|.   |||:|.         .|.| .|
 Worm   378 GLIGSSSTSSLASNVSMGSHQY------QSLLKQQIRDLVLRRKSLVRE---------DPEG-EG 426

  Fly   776 LSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLYASQ-LRNHQPSASGSPPHKVTT 839
            |:::                     .|..||..:.:||.:....|. |...:|:.        ||
 Worm   427 LAEL---------------------YNGLLPQAKLQQLQALAAESGFLAKQEPTC--------TT 462

  Fly   840 GLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAH 904
            ||.||..|::|.|.||:||.|.|:.||:||:|::|.|...|::|:::.|:||:.|:||.||::.:
 Worm   463 GLGYDQAMVRHECCCGNNASHVENGGRIQSIWSKLIEHGHVQKCEKVTAKKASLEQLQLVHSQTY 527

  Fly   905 AMLFG----------SNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGC 959
            ...|.          :|...|.|          |::|.|||:|||.||.:|:..|.||||:|||.
 Worm   528 TTFFAVSPTACLKIDANSLPLKR----------FLQLPCGGIGVDSDTYFNDASTQTAARLAAGT 582

  Fly   960 VIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMP-EVRRILIVDWD 1023
            :|:|:.:.|:|.|:||||.:||||||||...||||||||::|:|.|:|:.:.| :..:|.|:|||
 Worm   583 LIELSSQVAEGRLKNGFACIRPPGHHAEHEQAMGFCFFNNVAVAVKVLQTKYPAQCAKIAIIDWD 647

  Fly  1024 VHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDA 1088
            ||||||||.:|...|::||:|:||||.||||||||..||.|.....|..||:.:||.:   :.|.
 Worm   648 VHHGNGTQLSFENDPNVLYMSLHRHDKGNFFPGTGSVTEVGKNDAKGLTVNVPFSGDV---MRDP 709

  Fly  1089 EYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVL 1153
            ||:||:|||:.|:..||.||.::||:||||..|||..||||.|:|..||:||:.||..|:|||||
 Worm   710 EYLAAWRTVIEPVMASFCPDFIIVSAGFDACHGHPNALGGYEVTPEMFGYMTKSLLNYASGKVVL 774

  Fly  1154 ALEGGYDLAAICDSAQECVRALLG--DPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRM 1216
            ||||||||.:|.::||:||:||:|  |.|..::...||..|..:|:.||||.|||.:::||.:..
 Worm   775 ALEGGYDLKSISEAAQQCVQALIGESDDAGRLSSVALESLPNPSAVETLQKVIAIHKSYWPALHG 839

  Fly  1217 LEHTVGLSALE--TLKVE 1232
            .|..:..:.::  .||::
 Worm   840 QEAAINTTEMQWRNLKLQ 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	ClassIIa_HDAC_Gln-rich-N	43..>87	CDD:421006
		HDAC_classIIa	837..1211	CDD:212544	192/386 (50%)
hda-4	NP_001257278.1	HDAC_classIIa	460..834	CDD:212544	192/394 (49%)