DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and hda-4

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001257278.1	Gene:	hda-4 / 181723	WormBaseID:	WBGene00001837	Length:	869	Species:	Caenorhabditis elegans

Alignment Length:	993	Identity:	308/993 - (31%)
Similarity:	454/993 - (45%)	Gaps:	272/993 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 SSPSLPNI------SLGRPHLPNSAQAHAQVNAQVAAQAQ---------AQAQAQAQ-AHAMFAA 411
            :.||:||:      ::|:.:|...:.|..|...|...|.|         ||.:...| .|.::||
Worm    14 AGPSVPNLPSTSEAAIGQTNLEPESIALLQSQLQEYRQKQMDLIGHFQRAQQELSVQHMHNLYAA 78

  Fly   412 LAAAQGGCGQPGYYNPLGMAFVGRQPA-PLAMIPATGIAPQQPSPVVRSASATSTSSSQASLVGD 475
            |...|          .|......|... ||.:........|...|....:.|.|.::..:|..|:
Worm    79 LQQQQ----------QLQNLQTERSAVNPLLISQQHSTEDQNSGPAAPLSLANSLTNLLSSSNGN 133

  Fly   476 VAPPQA-----HAASTI------LP-SSSSYMQQL-------------GSVAGSGVNLHAAAVAA 515
            ::.||.     |..:..      || |:|:.:.||             ...:.|..||.:.:|.|
Worm   134 LSVPQTPTKEHHPTAPTSNRKCDLPRSNSTTISQLTKDRLKNMIANRSKGESNSQSNLMSNSVTA 198

  Fly   516 AAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQ 580
                                             :|:||.:|
Worm   199 ---------------------------------NGNGHDNG------------------------ 206

  Fly   581 GHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHYE---------NSEAERQAYEHQVVNQKVRQTV 636
              |.|..:.|              |:||...|:|         |:...:||.|.|:........:
Worm   207 --RKLKNSNS--------------QVNVSSPHFEPYRLPTSLANAHNLQQASEFQLRKVNSEPNL 255

  Fly   637 LTRSGAAAAAAAAAGVSVVRE---------AQLKEEDDDSAAEV----MDLTDKKKPPKTVLTST 688
            ..|..|...:..::.|..|::         .|||..|.:::..|    |..:.:...|..:|
Worm   256 KMRIRAKLLSKGSSPVQHVQQNNSQFNFTHPQLKRSDSETSQNVPLDFMQSSSQTNLPHLML--- 317

  Fly   689 IATSTSQNLPEALAAAAA-----------AAAYRAPHNAS------------------------- 717
                .|.:||. ||||.|           ..|:.|..|.|
Worm   318 ----PSPSLPN-LAAAGAFHGLNLPVGQDLNAFMAVANLSPFLSLPSLLNKKLELGGLTDEGDRN 377

  Fly   718 ----SNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELA---KSLMRPLSRTLSSPLVPLGPHG 775
                |:|.|:..|.:.:...:|      |.||.||..:|.   |||:|.         .|.| .|
Worm   378 GLIGSSSTSSLASNVSMGSHQY------QSLLKQQIRDLVLRRKSLVRE---------DPEG-EG 426

  Fly   776 LSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLYASQ-LRNHQPSASGSPPHKVTT 839
            |:::                     .|..||..:.:||.:....|. |...:|:.        ||
Worm   427 LAEL---------------------YNGLLPQAKLQQLQALAAESGFLAKQEPTC--------TT 462

  Fly   840 GLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAH 904
            ||.||..|::|.|.||:||.|.|:.||:||:|::|.|...|::|:::.|:||:.|:||.||::.:
Worm   463 GLGYDQAMVRHECCCGNNASHVENGGRIQSIWSKLIEHGHVQKCEKVTAKKASLEQLQLVHSQTY 527

  Fly   905 AMLFG----------SNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGC 959
            ...|.          :|...|.|          |::|.|||:|||.||.:|:..|.||||:|||.
Worm   528 TTFFAVSPTACLKIDANSLPLKR----------FLQLPCGGIGVDSDTYFNDASTQTAARLAAGT 582

  Fly   960 VIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMP-EVRRILIVDWD 1023
            :|:|:.:.|:|.|:||||.:||||||||...||||||||::|:|.|:|:.:.| :..:|.|:|||
Worm   583 LIELSSQVAEGRLKNGFACIRPPGHHAEHEQAMGFCFFNNVAVAVKVLQTKYPAQCAKIAIIDWD 647

  Fly  1024 VHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDA 1088
            ||||||||.:|...|::||:|:||||.||||||||..||.|.....|..||:.:||.:   :.|.
Worm   648 VHHGNGTQLSFENDPNVLYMSLHRHDKGNFFPGTGSVTEVGKNDAKGLTVNVPFSGDV---MRDP 709

  Fly  1089 EYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVL 1153
            ||:||:|||:.|:..||.||.::||:||||..|||..||||.|:|..||:||:.||..|:|||||
Worm   710 EYLAAWRTVIEPVMASFCPDFIIVSAGFDACHGHPNALGGYEVTPEMFGYMTKSLLNYASGKVVL 774

  Fly  1154 ALEGGYDLAAICDSAQECVRALLG--DPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRM 1216
            ||||||||.:|.::||:||:||:|  |.|..::...||..|..:|:.||||.|||.:::||.:..
Worm   775 ALEGGYDLKSISEAAQQCVQALIGESDDAGRLSSVALESLPNPSAVETLQKVIAIHKSYWPALHG 839

  Fly  1217 LEHTVGLSALE--TLKVE 1232
            .|..:..:.::  .||::
Worm   840 QEAAINTTEMQWRNLKLQ 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	192/386 (50%)
hda-4	NP_001257278.1	HDAC_classIIa	460..834	CDD:212544	192/394 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167689
Domainoid	1	1.000	342	1.000	Domainoid score	I569
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	1	1.000	-	-		FOG0001001
OrthoInspector	1	1.000	-	-		oto20722
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	1	1.000	-	-		X933
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.880