Protein Alignment HDAC4 and Hdac6

DIOPT Version :10

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_063135796.1
• Gene: Hdac6 / 108348065
• RGDID: 619981
• Length: 1164
• Species: Rattus norvegicus
• Alignment Length: 536
• Identity: 178/536 - (33%)
• Similarity: 261/536 - (48%)
• Gaps: 63/536 - (11%)

  Fly   707 AAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQE-----EELAKSLMRPLSRTLSS 766
            ||.:.|.|.......|||.:|. .....:|.......|:|..|     ..|||.:...|...|..
  Rat   341 AAGFDALHGDPKGEMSATPAGF-AHLTHFLMGLAGGKLILSLEGGYNLHALAKGVSGSLHTLLGD 404

  Fly   767 PLVPLGPHGLSQIPDTGQQPAPIATSSSA--------DHIPP----VNLSLPHRQHRQLMSTLYA 819
            |...|              .:|:|..:||        :.:.|    :..|:..:...::...:..
  Rat   405 PCPML--------------ESPVAPCASAQTSISCTLEALEPFWEVLERSVEPQDEDEVEGDMLE 455

  Fly   820 SQLRNHQPSASGSPPH-----KVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDL 879
            .:.......|:..|..     :..|||.||..|:.| |...|| .|||...|:..:...|.|..|
  Rat   456 DEEEEGHWEATALPMDTWPLLQNRTGLVYDERMMSH-CNLWDN-HHPETPQRILRIMCHLEEVGL 518

  Fly   880 VKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTW 944
            ..||..|.||.|...||.|.|:..:.....:.:...:|.....              |.:.::.:
  Rat   519 AARCLILPARPALDSELLTCHSAEYVERLRATEKMKTRDLHRE--------------GANFESIY 569

  Fly   945 NEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQ 1009
            ....|...|::|.|....|......|::.||.|:|||||||||.:.|.|||||||:|:||:..:.
  Rat   570 ICPSTFACAQLATGAACRLVEAVLSGEVLNGIAIVRPPGHHAEPDAACGFCFFNSVAVAARHAQV 634

  Fly  1010 RMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFP--GTGGPTECGSGAGLGFN 1072
            ......||||||||||||||||..|.:.|.:||:|:||:|.|.|||  ..|..::.|..||.||.
  Rat   635 IAGRALRILIVDWDVHHGNGTQHIFEEDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRAAGTGFT 699

  Fly  1073 VNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFG 1137
            ||:.|:|   |.:|||:|:|.:..:|:|||..|||::||:|:|||||.|.  ||||..|:|..:.
  Rat   700 VNVPWNG---PRMGDADYLATWHRLVLPIAYEFNPELVLISAGFDAAQGD--PLGGCQVTPEGYA 759

  Fly  1138 FMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQK 1202
            .:|..|:.||.|:::|.|||||:|.:|.:|...|..:|||||...:...   |||...|:.::.:
  Rat   760 HLTHLLMGLAGGRIILILEGGYNLTSISESMAACTHSLLGDPPPQLTSL---RPPQSGALASISE 821

  Fly  1203 TIAIQQTHWPCVRMLE 1218
            .|.:.:.:|..:|:::
  Rat   822 VIQVHRKYWRSLRLMK 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	ClassIIa_HDAC_Gln-rich-N	43..>87	CDD:421006
		HDAC_classIIa	837..1211	CDD:212544	149/375 (40%)
Hdac6	XP_063135796.1	None