Protein Alignment CG4332 and CLPTM1L

DIOPT Version :10

• Sequence 1: NP_572861.1
• Gene: CG4332 / 32267
• FlyBaseID: FBgn0030456
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_110409.2
• Gene: CLPTM1L / 81037
• HGNCID: 24308
• Length: 538
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 253/538 - (47%)
• Similarity: 346/538 - (64%)
• Gaps: 30/538 - (5%)

  Fly     5 SISTLLGVAFLAYIGHSIYQMSQLFTTLQCSG-VPCYTSFLADRPRLQLALFSSLSRSPIATE-- 66
            |.::|:...|:.|:.|:.:.|..:..|..||| ..|...:||.||:|||::::: :||.:..|
Human     7 SFTSLVVGVFVVYVVHTCWVMYGIVYTRPCSGDANCIQPYLARRPKLQLSVYTT-TRSHLGAENN 70

  Fly    67 VRDLYKAKRFDYDQNFEHDFEVDVPLRTRRNGSLYLHVVLALEGEPLEWRSLRRDGPTVVHTMSL 131
            :..:...:.||.:..||....|.||.:||.||:||.::.|...| .|.|    .||..|.....|
Human    71 IDLVLNVEDFDVESKFERTVNVSVPKKTRNNGTLYAYIFLHHAG-VLPW----HDGKQVHLVSPL 130

  Fly   132 TDYIVPRAEAFKLL-GDSEKGAAAAVQEKEKKKASTTGRPSTHIRSNVYVTLLNDLYSVSQADVP 195
            |.|:||:.|...|| |:|:....    |.|||..|....|.:|.|..:.:.::.|.:....:.:|
Human   131 TTYMVPKPEEINLLTGESDTQQI----EAEKKPTSALDEPVSHWRPRLALNVMADNFVFDGSSLP 191

  Fly   196 PEM---APLIRVNRNQQILPILQTDTFNTRLKDLVPVTRNTTEFTFSFHYKPVGVGKLRLMLLME 257
            .::   ..:|::.:....||||..|..:.|:|||:.:.|:|||...:..|..|.:|:||..:.|:
Human   192 ADVHRYMKMIQLGKTVHYLPILFIDQLSNRVKDLMVINRSTTELPLTVSYDKVSLGRLRFWIHMQ 256

  Fly   258 HATQALLTIGFATKDIDEVKGIFSDTNVYLLCGTIFVSSIHMLFDFLSFKNDVAFWRKKQSYEGL 322
            .|..:|...||:.||.|||||||.|||:|.|..|.||::.|:|||||:||||::||:||:|..|:
Human   257 DAVYSLQQFGFSEKDADEVKGIFVDTNLYFLALTFFVAAFHLLFDFLAFKNDISFWKKKKSMIGM 321

  Fly   323 SSRTTMWRAFSQIVIFFYLLDENTSYLVLVPVGLGTLIELWKCKKIFRLELSFSGLVRRKLEQVD 387
            |::..:||.||.:|||.:||||.||.|||||.|:|..|||||.||..::.:.:.||:..
Human   322 STKAVLWRCFSTVVIFLFLLDEQTSLLVLVPAGVGAAIELWKVKKALKMTIFWRGLMPE------ 380

  Fly   388 RRNGDQAGVKSGQLAEEQKTDQFDRQGMRYLSYLLYPLCICGAVYSLLYQPHRSWYSWTLNSLVN 452
                .|.|..|   ..|:||:::|.|.|:||||||||||:.|||||||...::|||||.:||.||
Human   381 ----FQFGTYS---ESERKTEEYDTQAMKYLSYLLYPLCVGGAVYSLLNIKYKSWYSWLINSFVN 438

  Fly   453 GVYAFGFLFMLPQLFVNYKLKSVAALPWRAFMYKAFNTFIDDFFAFIITMPTAHRVACLRDDIVF 517
            ||||||||||||||||||||||||.|||:||.||||||||||.|||||||||:||:||.|||:||
Human   439 GVYAFGFLFMLPQLFVNYKLKSVAHLPWKAFTYKAFNTFIDDVFAFIITMPTSHRLACFRDDVVF 503

  Fly   518 IIYLYQRWLYPVDKSRLD 535
            ::||||||||||||.|::
Human   504 LVYLYQRWLYPVDKRRVN 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4332	NP_572861.1	CLPTM1	7..436	CDD:461689	172/435 (40%)
CLPTM1L	NP_110409.2	CLPTM1	22..422	CDD:461689	169/422 (40%)