DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12717 and SENP3

DIOPT Version :9

Sequence 1:	NP_001285167.1	Gene:	CG12717 / 32229	FlyBaseID:	FBgn0030420	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_056485.2	Gene:	SENP3 / 26168	HGNCID:	17862	Length:	574	Species:	Homo sapiens

Alignment Length:	391	Identity:	84/391 - (21%)
Similarity:	149/391 - (38%)	Gaps:	112/391 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 MTSNGLRGVQPAEDAPAISQ----WIQSR----NNAAVSKKSEETAGGSQ-------------SR 290
            |..:|:||..|....|.:.:    |....    ::..:|.......||..             |.
Human   204 MAEDGVRGSPPVPSGPPMEEDGLRWTPKSPLDPDSGLLSCTLPNGFGGQSGPEGERSLAPPDASI 268

  Fly   291 VQSNVASISSPAVKAT---SDAAIPTPAER-----AERSRLRRNRNWILSRDVDE-----DAVVL 342
            :.|||.||.....:..   ||..:...|||     .:.|.||......:...:||     .:::.
Human   269 LISNVCSIGDHVAQELFQGSDLGMAEEAERPGEKAGQHSPLREEHVTCVQSILDEFLQTYGSLIP 333

  Fly   343 VSSGDEETTAADDGQTERRLSPDEN----QTLFTYPPTGTGGL-----------SITIKDFMCLS 392
            :|: ||.....:|...:...:|...    |.:.:|.......:           .:|:.|...|.
Human   334 LST-DEVVEKLEDIFQQEFSTPSRKGLVLQLIQSYQRMPGNAMVRGFRVAYKRHVLTMDDLGTLY 397

  Fly   393 KGSYLNDIIIDFYLRWLKNNIIPEEQRDRTHIFSTFFHKRLTTRTNPRNTKQTAAQKRHERVEKW 457
            ..::|||.:::.|     .:::.:...::.|.|::||:.:|.|             |.::.|::|
Human   398 GQNWLNDQVMNMY-----GDLVMDTVPEKVHFFNSFFYDKLRT-------------KGYDGVKRW 444

  Fly   458 TRNVNIFDKDFIIIPFNEQSHWILAIICYPNLRSPVVNNNNVQTTLSDDIPIKQPLILIFDSLAV 522
            |:||:||:|:.::||.:.:.||.|.                       .:.:::..|..|||...
Human   445 TKNVDIFNKELLLIPIHLEVHWSLI-----------------------SVDVRRRTITYFDSQRT 486

  Fly   523 TSRHRAIAILRDYLTC-EHKAKYPNALAHVFNKDNMPGH-------SVEVPQQQNLTDCGLYLLQ 579
            .:|.           | :|.|||..|.|  ..||.:..|       .:.|.:|.|.:|||.::||
Human   487 LNRR-----------CPKHIAKYLQAEA--VKKDRLDFHQGWKGYFKMNVARQNNDSDCGAFVLQ 538

  Fly   580 Y 580
            |
Human   539 Y 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12717	NP_001285167.1	BASP1	122..319	CDD:283191	21/100 (21%)
CG12717	NP_001285167.1	Peptidase_C48	396..585	CDD:304959	48/193 (25%)
SENP3	NP_056485.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..125
		Nuclear localization signal. /evidence=ECO:0000255	125..128
		Nuclear localization signal. /evidence=ECO:0000255	153..159
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..181
		Protease	386..543		51/208 (25%)
		Peptidase_C48	400..572	CDD:280975	48/194 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810