DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11085 and lbx2

DIOPT Version :9

Sequence 1:	NP_572815.3	Gene:	CG11085 / 32213	FlyBaseID:	FBgn0030408	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_001007135.1	Gene:	lbx2 / 64276	ZFINID:	ZDB-GENE-001206-2	Length:	257	Species:	Danio rerio

Alignment Length:	195	Identity:	58/195 - (29%)
Similarity:	85/195 - (43%)	Gaps:	46/195 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 GGGGVASGLSAAAA--------AAGVAAGLLAAAASGANGDRDANGGSGPGSGGGTSGGYAEHKL 151
            |.....:|:||.::        |:....||..:....|.|....|               |..:.
Zfish    71 GSSASRNGISAPSSPLCALEELASKTFKGLEVSVIQAAEGREHIN---------------AFGQR 120

  Fly   152 QLSKSGRKPRRRRTAFTHAQLAYLERKFRCQKYLSVADRSDVAETLNLSETQVKTWYQNRRTKWK 216
            |.||   |.|:.|||||:.|:..||::|..|||||.|||..:|:.|.|:..||.||:||||.|.|
Zfish   121 QASK---KRRKSRTAFTNHQIYELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKLK 182

  Fly   217 RQ-----------NQLRLEQLRHQATMEKDFVVQDGGGAGGLGCCPSGLSSSFSAAAAAAAAASN 270
            |.           .::..:.|:...:||.   ::|..|..|      .:|.|.|..|...:.:|:
Zfish   183 RDLEEMKADVESLKKIPPQALQKLVSMED---MEDAHGGSG------PISPSLSPRAFPQSPSSS 238

Fly 271 270
Zfish 239 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11085	NP_572815.3	Homeobox	163..216	CDD:278475	29/52 (56%)
lbx2	NP_001007135.1	Required for convergent extension movement and hypaxial myogenesis during gastrulation. Required for the formation of thick and thin myofilaments. Required for myod1 expression in the pectoral fin bud. Required for continuous expression of cxcl12a in the posterior lateral mesoderm at the tail bud stage and in adaxial cells at the 10-somite stage. /evidence=ECO:0000269\|PubMed:19216761, ECO:0000269\|PubMed:22216300, ECO:0000269\|PubMed:22406073	1..46
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		Homeobox	129..183	CDD:395001	29/53 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..257		10/42 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810