DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11085 and BARHL1

DIOPT Version :9

Sequence 1:	NP_572815.3	Gene:	CG11085 / 32213	FlyBaseID:	FBgn0030408	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_064448.1	Gene:	BARHL1 / 56751	HGNCID:	953	Length:	327	Species:	Homo sapiens

Alignment Length:	232	Identity:	85/232 - (36%)
Similarity:	105/232 - (45%)	Gaps:	62/232 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DSTAAGCQQELLLSHHHRRFTHHDESSVESCLSATRGPG-----SGTGSGGGGGGGG-GGGVASG 102
            |.....|:..|.||       ...|||  |..|:...||     :||...||..|.| ...:..|
Human    26 DPLLGDCRSPLELS-------PRSESS--SDCSSPASPGRDCLETGTPRPGGASGPGLDSHLQPG 81

  Fly   103 -LSAAAAAAGVAAGL-----------LAAAASGANGDRDANGGSGPGSGGGTSGGYAE-HKLQLS 154
             |||.|.:..|.:..           |||.|..::..:.|    .|..||..:...|| .:.:|.
Human    82 QLSAPAQSRTVTSSFLIRDILADCKPLAACAPYSSSGQPA----APEPGGRLAAKAAEDFRDKLD 142

  Fly   155 KSG------------------------------RKPRRRRTAFTHAQLAYLERKFRCQKYLSVAD 189
            |||                              :|||:.|||||..|||.|||.|..||||||.|
Human   143 KSGSNASSDSEYKVKEEGDREISSSRDSPPVRLKKPRKARTAFTDHQLAQLERSFERQKYLSVQD 207

  Fly   190 RSDVAETLNLSETQVKTWYQNRRTKWKRQNQLRLEQL 226
            |.::|.:|||::|||||||||||||||||..:.||.|
Human   208 RMELAASLNLTDTQVKTWYQNRRTKWKRQTAVGLELL 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11085	NP_572815.3	Homeobox	163..216	CDD:278475	37/52 (71%)
BARHL1	NP_064448.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90		23/72 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..184		15/75 (20%)
		Homeobox	182..235	CDD:395001	38/52 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1387
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.770