Protein Alignment CG11085 and NKX1-2

DIOPT Version :10

• Sequence 1: NP_572815.3
• Gene: CG11085 / 32213
• FlyBaseID: FBgn0030408
• Length: 295
• Species: Drosophila melanogaster
• Sequence 2: NP_001139812.1
• Gene: NKX1-2 / 390010
• HGNCID: 31652
• Length: 310
• Species: Homo sapiens
• Alignment Length: 288
• Identity: 96/288 - (33%)
• Similarity: 127/288 - (44%)
• Gaps: 64/288 - (22%)

  Fly    20 RQTDSELELSNDDSDID-IEDRSTPDSTAAGCQQELLLSHHHRRFTHHDESSVESCLSATRGPGS 83
            |::.:|:|...|.|..| :....|||:...|..|...|        ...|:..|......|.|..
Human    47 RKSLAEVEAGKDASSRDPVRQLETPDAAGPGAGQASPL--------EGSEAEEEEDAEDPRRPRL 103

  Fly    84 GTGSGGGGGGGGGGGVASGLSAAAAAAGVAAGLLAAAASGANGDRDANGGSGP-GSGGGTSGGYA 147
            ..                  .||....|:|....|.|.:.|:|:...:||.|| .|..|:.|...
Human   104 RE------------------RAARLLPGLARSPDAPAGALASGEPCEDGGGGPVRSPPGSPGSPR 150

  Fly   148 EHKLQLSKSGRKPRRRRTAFTHAQLAYLERKFRCQKYLSVADRSDVAETLNLSETQVKTWYQNRR 212
            ..:.:|..:..||||.|||||:.||..||.|||..:||||.:|.::|.:|:|:|||||.|:||||
Human   151 PRRRRLEPNCAKPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRR 215

  Fly   213 TKWKRQNQLRLEQLRHQATMEKDFVVQDGGGA-----------GGLGCCPS--GLSS-------S 257
            ||||:||.            ..|...|.||||           ||.|..|.  |..:       |
Human   216 TKWKKQNP------------GADGAAQVGGGAPQPGAAGGGGGGGSGGSPGPPGTGALHFQTFPS 268

  Fly   258 FSAA-AAAAAAASNPCNFLTSAAAAAIF 284
            :||| ....:|||.|   ||:||..:.|
Human   269 YSAANVLFPSAASFP---LTAAAPGSPF 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11085	NP_572815.3	Homeodomain	161..217	CDD:459649	35/55 (64%)
NKX1-2	NP_001139812.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..165		34/143 (24%)
		Homeodomain	164..220	CDD:459649	35/55 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	217..260		16/54 (30%)