DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11085 and LBX1

DIOPT Version :9

Sequence 1:	NP_572815.3	Gene:	CG11085 / 32213	FlyBaseID:	FBgn0030408	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_006553.2	Gene:	LBX1 / 10660	HGNCID:	16960	Length:	281	Species:	Homo sapiens

Alignment Length:	227	Identity:	67/227 - (29%)
Similarity:	88/227 - (38%)	Gaps:	74/227 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 AAGLLAAAASGANGDRDANGG-----------------------------------SGPGSGGGT 142
            ||.|||||      |:.|.||                                   :..|..|.|
Human    56 AAHLLAAA------DKHAQGGLPLAGRALLSQTSPLCALEELASKTFKGLEVSVLQAAEGRDGMT 114

  Fly   143 SGGYAEHKLQLSKSGRKPRRRRTAFTHAQLAYLERKFRCQKYLSVADRSDVAETLNLSETQVKTW 207
            ..|..:       :.:|.|:.|||||:.|:..||::|..|||||.|||..:|:.|.|:..||.||
Human   115 IFGQRQ-------TPKKRRKSRTAFTNHQIYELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITW 172

  Fly   208 YQNRRTKWKRQNQLRLEQLRHQATMEK--------DFVV---------QDGGGAGGLGCCPSG-- 253
            :||||.|.||.    ||:::......|        |.|.         ...||.||.|...|.
Human   173 FQNRRAKLKRD----LEEMKADVESAKKLGPSGQMDIVALAELEQNSEATAGGGGGCGRAKSRPG 233

  Fly   254 ---LSSSFSAAAAAAAAASNPCNFLTSAAAAA 282
               |......|..|.|...:|.:.||...|::
Human   234 SPVLPPGAPKAPGAGALQLSPASPLTDQPASS 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11085	NP_572815.3	Homeobox	163..216	CDD:278475	29/52 (56%)
LBX1	NP_006553.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		Homeobox	128..181	CDD:278475	29/52 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..281		14/52 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900