Protein Alignment Pits and Irf2bp2

DIOPT Version :10

• Sequence 1: NP_001138192.1
• Gene: Pits / 32205
• FlyBaseID: FBgn0030400
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_001387925.1
• Gene: Irf2bp2 / 679357
• RGDID: 1589517
• Length: 571
• Species: Rattus norvegicus
• Alignment Length: 707
• Identity: 223/707 - (31%)
• Similarity: 287/707 - (40%)
• Gaps: 227/707 - (32%)

  Fly     5 TKRQHCYLCDLPRMPWAMINDFSEAVCRGCVNYEGADRIEAVLDAARQMKRLHPASKQQRSHENG 69
            ::||.||||||||||||||.||:|.|||||||||||||:|.|::.|||:||.|...::.||
  Rat    11 SRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRVEFVIETARQLKRAHGCFQEGRS---- 71

  Fly    70 EVSAAAAAAVVLQQQQQLQVGPVPGQGPGSHRGGGGGGPPGAPPGSGGPGPSGAGSL-----SSL 129
                                                  |.||.|.|..|.|..|..|     ..|
  Rat    72 --------------------------------------PTGAQPASAKPPPLSAKDLLLQPPPQL 98

  Fly   130 GNAVAAAAAAAAVHHHHQMPYQMPVPRIGPPLDYPVKLEDAPGGGVRPVRISHMTPHHLPPNATR 194
            |:|.|.||.|.|:..                  ||:..:.||       |::       ...:||
  Rat    99 GHAGAEAARAQAMER------------------YPLAPDRAP-------RLA-------SEFSTR 131

  Fly   195 GGGGAPGGGVPTAGSGGGSLPPALSVNLKRPPSEDVDVDVSQQQQQSGHGLAP------DGSAGN 253
            .|.|.|...........|.|.|.....|:.||    :::......:..|.:.|      :|||..
  Rat   132 AGAGLPQSAASQPSPANGILVPNGFSKLEEPP----ELNRQSPNPRRAHAVPPTLVPLVNGSAAL 192

  Fly   254 SLSAGGGVSGGCPPGIKRSAMDDPSGVGGRPPLTRGESLPAAVSYV----PERQLSGLRDKQQPV 314
            .||.....:        .:|:....|:|.:|........||:||..    ..|:.|  ::|.||.
  Rat   193 GLSGRAAAT--------LAAVSGTPGLGAQPAELGTHKRPASVSSAAAEHEAREQS--KEKAQPA 247

  Fly   315 RAPSFDASTFKAANPIPNPIPHHLHIAEHMSPASRRNGSSPPSGPLPPRSVHSPNSSGSSSGR-R 378
                                        |.|||...:|::..|           ..|..|:|: |
  Rat   248 ----------------------------HRSPADSLSGTTGAS-----------ELSAESAGKGR 273

  Fly   379 SSGSRHVSSTTVTSSEV--------GGSNPGQ-------AVVAGG--LGGGGGGGPGSNAAS--- 423
            :.|.:..:|...|..:.        |.|.|.:       |:.|.|  ||....|..||.|.:
  Rat   274 APGEQDWASRPKTVRDTLLALHHQHGHSGPFESKFKKEPALTAAGRLLGFEANGANGSKAVARTA 338

  Fly   424 ----------GQLGGPS-GGSGQ--LSCTSGG------PGGSASSGSGGNGAIGPASMAPNSVAG 469
                      |::|.|. .|..|  ||.::.|      |..|..|..       |.:.:|:|...
  Rat   339 RKRKPSPEPEGEVGPPKINGEAQPWLSTSTEGLKIPITPTSSFVSPP-------PPTASPHSNRT 396

  Fly   470 DGSPAGGNGPS-------------GSNGS------------GGSVNPGPGSSGSQGGGGGGTPLA 509
            ....|..||.|             ||:.|            ..|..|.|.|...:..|    |..
  Rat   397 TPPEAAQNGQSPMAALILVADNAGGSHASKDTTQVHSTTRRNSSSPPSPSSMNQRRLG----PRE 457

  Fly   510 SGGGSAGS-GGLGGAPGSSAASNSAAAAAAAAAQNATLKCTLCQERLEDTHFVQCPSVNHHKFCF 573
            .||.:.|| |||.....:|...:|.||       :|.|.||||.||||||||||||||..|||||
  Rat   458 VGGQATGSTGGLEPVHPASLPDSSLAA-------SAPLCCTLCHERLEDTHFVQCPSVPSHKFCF 515

  Fly   574 PCSRESIKRQNGLGNEVYCPSGDRCPLANSVIPWAFMQGEITTILGEEVKVKKERES 630
            ||||:|||:| |...|||||||::|||..|.:|||||||||.|||..:|||||||:|
  Rat   516 PCSRQSIKQQ-GASGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDS 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:463250	39/50 (78%)
		vRING-HC_IRF2BP1-like	546..602	CDD:438174	43/55 (78%)
Irf2bp2	NP_001387925.1	IRF-2BP1_2	12..63	CDD:463250	39/50 (78%)
		PHA03247	<70..408	CDD:223021	97/471 (21%)
		vRING-HC_IRF2BP2	487..553	CDD:438376	49/66 (74%)