Protein Alignment Pits and IRF2BP2

DIOPT Version :10

• Sequence 1: NP_001138192.1
• Gene: Pits / 32205
• FlyBaseID: FBgn0030400
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_892017.2
• Gene: IRF2BP2 / 359948
• HGNCID: 21729
• Length: 587
• Species: Homo sapiens
• Alignment Length: 696
• Identity: 222/696 - (31%)
• Similarity: 287/696 - (41%)
• Gaps: 189/696 - (27%)

  Fly     5 TKRQHCYLCDLPRMPWAMINDFSEAVCRGCVNYEGADRIEAVLDAARQMKRLHPASKQQRSHENG 69
            ::||.||||||||||||||.||:|.|||||||||||||:|.|::.|||:||.|....:.||....
Human    11 SRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRVEFVIETARQLKRAHGCFPEGRSPPGA 75

  Fly    70 EVSAAA------AAAVVLQQQQQLQVGPVPGQGPGSHRGGGGGGPPGAPPGSGG----PGPSGAG 124
            ..||||      |..::|||||||                |.|||..||.....    |..:.|.
Human    76 AASAAAKPPPLSAKDILLQQQQQL----------------GHGGPEAAPRAPQALERYPLAAAAE 124

  Fly   125 SLSSLGNAVAAAAAAAAVHHHHQMPYQMPVPRIGPPLDYPV----------KLEDAP-------- 171
            ....||:...::..||::       .|.|.|:  ||   ||          |||:.|
Human   125 RPPRLGSDFGSSRPAASL-------AQPPTPQ--PP---PVNGILVPNGFSKLEEPPELNRQSPN 177

  Fly   172 ---GGGVRPVRISHMTPHHLP-PNATRGGGGAPGGGVPTAGSGGGSLPPALSVNL---KRPPSED 229
               |..|.|..:..|.....| |.|...||.|.......:|:...||..|...:|   |||.|..
Human   178 PRRGHAVPPTLVPLMNGSATPLPTALGLGGRAAASLAAVSGTAAASLGSAQPTDLGAHKRPASVS 242

  Fly   230 VDVDVSQQQQQSG---HGLAPDGSAG--NSLSAGGGVSGGCPPGIKRSAMDDPSGVGGRPPLTR- 288
            ....|..:|:::.   ....|....|  :|||...|.:.....|..:|..........||...|
Human   243 SSAAVEHEQREAAAKEKQPPPPAHRGPADSLSTAAGAAELSAEGAGKSRGSGEQDWVNRPKTVRD 307

  Fly   289 --------GESLPAAVSYVPERQLSGLRDKQQPV----RAPSFDASTFKAANPIPNPIPHHLHIA 341
                    |.|.|....:           |::|.    |...|:|:....:..:..
Human   308 TLLALHQHGHSGPFESKF-----------KKEPALTAGRLLGFEANGANGSKAVAR--------- 352

  Fly   342 EHMSPASRRNGSSPPSGPLPPRSVH---SPNSSGSSSGRR--------------SSGSRHVSSTT 389
                .|.:|..|..|.|.:.|..::   .|..|.|:.|.:              .:.|.|.:.||
Human   353 ----TARKRKPSPEPEGEVGPPKINGEAQPWLSTSTEGLKIPMTPTSSFVSPPPPTASPHSNRTT 413

  Fly   390 VTSSEVGGSNPGQAVVAGGLGGGGGGGPGSNAASGQLGGPSGGSGQLSCTSGGPGGSASSGSGGN 454
            ...:...|.:|..|::.  :....||...|..|:           |:..|:.....|..|
Human   414 PPEAAQNGQSPMAALIL--VADNAGGSHASKDAN-----------QVHSTTRRNSNSPPS----- 460

  Fly   455 GAIGPASMAPNSVAGDGSPAGGNGPSGSNGSGGSVNPGPGSSGSQGGGGGGTPLASGGGSAGSGG 519
                |:||....:                        ||...|.||.|             .:||
Human   461 ----PSSMNQRRL------------------------GPREVGGQGAG-------------NTGG 484

  Fly   520 LGGAPGSSAASNSAAAAAAAAAQNATLKCTLCQERLEDTHFVQCPSVNHHKFCFPCSRESIKRQN 584
            |.....:|...:|.|.       :|.|.||||.||||||||||||||..|||||||||:|||:|
Human   485 LEPVHPASLPDSSLAT-------SAPLCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQ- 541

  Fly   585 GLGNEVYCPSGDRCPLANSVIPWAFMQGEITTILGEEVKVKKERES 630
            |...|||||||::|||..|.:|||||||||.|||..:|||||||:|
Human   542 GASGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDS 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:463250	39/50 (78%)
		vRING-HC_IRF2BP1-like	546..602	CDD:438174	43/55 (78%)
IRF2BP2	NP_892017.2	IRF-2BP1_2	12..63	CDD:463250	39/50 (78%)
		PHA03247	<102..424	CDD:223021	77/357 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	126..192		18/77 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..306		18/80 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	342..420		14/90 (16%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:21887377	354..361		2/6 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	437..494		20/113 (18%)
		vRING-HC_IRF2BP2	503..569	CDD:438376	49/66 (74%)
		Cys-rich	506..550		35/44 (80%)