DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pits and MYT1L

DIOPT Version :9

Sequence 1:	NP_001138192.1	Gene:	Pits / 32205	FlyBaseID:	FBgn0030400	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_011508620.1	Gene:	MYT1L / 23040	HGNCID:	7623	Length:	1209	Species:	Homo sapiens

Alignment Length:	501	Identity:	94/501 - (18%)
Similarity:	148/501 - (29%)	Gaps:	160/501 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 KRPPSEDVDVDVSQQQQQSGHGLAPDGSAGNSLS---------------AGGGVSGGCPPGIKRS 272
            :|.|.:::::....:.::...|..||.:..:.|:               |......||     ..
Human   348 ERNPQQNMNIRQHVRPEEDFPGRTPDRNYSDMLNLMRLEEQLSPRSRVFASCAKEDGC-----HE 407

  Fly   273 AMDDPSGVGGRP-----PLTRGE--SLPAAVSYVPER---------QLSGLRDK------QQPVR 315
            ..||.:.|....     .:|:|.  .|..|::...||         ..:|.||.      |.|.:
Human   408 RDDDTTSVNSDRSEEVFDMTKGNLTLLEKAIALETERAKAMREKMAMEAGRRDNMRSYEDQSPRQ 472

  Fly   316 APSFD-------------------ASTFKAANPIPNP-----------IPHHLHIAEHMSPASRR 350
            .|..|                   :.|.|..:..|.|           .|||           |.
Human   473 LPGEDRKPKSSDSHVKKPYYGKDPSRTEKKESKCPTPGCDGTGHVTGLYPHH-----------RS 526

  Fly   351 NGSSPPSGPLPPR--SVH-------SPNSSGS---SSGRRSSGSRHVSSTTVTSSE--VGGSNPG 401
            ....|....:||.  ::|       :|..:|.   :|.|.|  .|.:|...:.::|  .......
Human   527 LSGCPHKDRVPPEILAMHESVLKCPTPGCTGRGHVNSNRNS--HRSLSGCPIAAAEKLAKAQEKH 589

  Fly   402 QAVVAGGLGGGGGGGPGSNAASGQLGGPSGGSGQLSCTSGG---------PGGSASS-------- 449
            |:....          .|:.||.::..|.....||.....|         |..:.:.
Human   590 QSCDVS----------KSSQASDRVLRPMCFVKQLEIPQYGYRNNVPTTTPRSNLAKELEKYSKT 644

  Fly   450 ----GSGGNGAIGPASMAPNSVAGDGSPAGGN-------GPSGSNGSGGSVNPGPGSSGSQGGGG 503
                .|..|...|..::||.....|.||.|.:       .||.|:.|..|..|...|:
Human   645 SFEYNSYDNHTYGKRAIAPKVQTRDISPKGYDDAKRYCKDPSPSSSSTSSYAPSSSSN------- 702

  Fly   504 GGTPLASGGGSAGSGGLGGAPGSSAASNSAAAAAAAAAQNATLKCTLCQERLEDTHFVQCPSVNH 568
                |:.||||:.|.....:.........||..||.|..|.:.:|....:.|         |...
Human   703 ----LSCGGGSSASSTCSKSSFDYTHDMEAAHMAATAILNLSTRCREMPQNL---------STKP 754

  Fly   569 HKFCFPCSRESIKRQNG---LGNEVYCPSGDRCPLANSVIPWAFMQ 611
            ...|...:.:....:||   |......|....||:...:.|.:..|
Human   755 QDLCATRNPDMEVDENGTLDLSMNKQRPRDSCCPILTPLEPMSPQQ 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:288155
Pits	NP_001138192.1	zf-C3HC4	548..593	CDD:278524	7/47 (15%)
MYT1L	XP_011508620.1	zf-C2HC	30..56	CDD:279824
		zf-C2HC	505..531	CDD:279824	6/36 (17%)
		zf-C2HC	549..575	CDD:279824	7/27 (26%)
		MYT1	621..872	CDD:285648	41/200 (21%)
		zf-C2HC	882..907	CDD:279824
		zf-C2HC	925..951	CDD:279824
		zf-C2HC	974..1000	CDD:279824
		zf-C2HC	1027..1053	CDD:279824
		Rota_VP2	1075..>1141	CDD:282884
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158357
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930