DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hwt and hwt

DIOPT Version :10

Sequence 1:NP_001259484.1 Gene:hwt / 32202 FlyBaseID:FBgn0264542 Length:1768 Species:Drosophila melanogaster
Sequence 2:XP_061517846.1 Gene:hwt / 1271063 VectorBaseID:AGAMI1_011508 Length:1379 Species:Anopheles gambiae


Alignment Length:1871 Identity:747/1871 - (39%)
Similarity:930/1871 - (49%) Gaps:595/1871 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MERMWRKVNHSLR-NTSKSQAQQAAGGDG---------IIGGPATGATAATP--QSTDTISSAGG 53
            |||:|||||..|. .:|.|:|...|||..         :..||:.|.:|..|  .||||.||| |
Mosquito     1 MERVWRKVNQGLTLRSSSSKATATAGGGASGGPNAASLVTAGPSAGPSAGGPTHHSTDTTSSA-G 64

  Fly    54 FGDGQLVVAVQGLASGGIGASITASGGSNATGRRLASSGGGGGCNKSLSQHVLQTRTASSERRRR 118
            ||:.| |||||                                  :..|..|.|..|||||:|||
Mosquito    65 FGESQ-VVAVQ----------------------------------RRRSVVVPQASTASSEKRRR 94

  Fly   119 RRRKSRPRRGGGMGVTSCVGDPGGDNMSSSGGFYTLKEHQHYRPSHHHGGGVSVGVGGGSSRRLF 183
            |||:|||.|.|.               |.||               |..||...|...|..|   
Mosquito    95 RRRRSRPSREGA---------------SQSG---------------HGSGGHHKGHSSGGRR--- 126

  Fly   184 ATSAPSGTVMMYPNPQRGTALAPSVGSGTGHANTAGLGGGGGGGAGGAGGGATGSGTGGQPDISL 248
             :::.|.|:....|.|                                               ||
Mosquito   127 -SNSQSVTIAQQSNEQ-----------------------------------------------SL 143

  Fly   249 RQRAVAKLRMFNFHLNWDLHMTHCKPCGPRLSGSGGNIITRRLCRNRRREDNELYRSNSFKFERF 313
            ||||||:|:||||:||||||||.||||||:   |.|||||||||||||.||||||||||||||||
Mosquito   144 RQRAVARLKMFNFNLNWDLHMTQCKPCGPK---SSGNIITRRLCRNRRGEDNELYRSNSFKFERF 205

  Fly   314 ERKECLEELSNT-LQKQIAICDDYSLPVDFVKKRPSSFDPCLAEAIPANPEHWIAPSPQTEFLPF 377
            |||:.:|..:.| |:|||::|||||||:||||||||||||||.:.||.|   |.:||||:|.:.|
Mosquito   206 ERKDPMEAGARTMLRKQISVCDDYSLPIDFVKKRPSSFDPCLVQHIPTN---WASPSPQSEHVSF 267

  Fly   378 GE---AQQALQLQPAAAAATAAATTSAAAA----ANATAAAPQLP-------PPL-PVPVATLPN 427
            .|   .||.|...|...:.....:.:.|::    ...|...|.||       |.| |:|......
Mosquito   268 LEPLLLQQPLSAVPTIVSNNVPGSVTIASSGIPPGTGTIGRPSLPLVPSASGPSLCPIPPLQPGP 332

  Fly   428 QAATAAAAATAAILATHQQQQQQQHQHLSNNNNNGGSTHGQQHTHSNNNNTLPVGAQQQQQQQHQ 492
            .|||.|||.|.||                                                    
Mosquito   333 DAATTAAAHTVAI---------------------------------------------------- 345

  Fly   493 QQRATLQHPPLPNSNIKQASVKLIEGYSDPKDTRNHKKVYHKKAKKRSTTGHKRHQQQQQQQQPH 557
                                 |.:|...|.:  |::|.....:|:.|:.                
Mosquito   346 ---------------------KTLEEIFDTR--RSYKPAGRHRARSRTR---------------- 371

  Fly   558 QQQLQQQQQQTLPTPRSAQQQQQLQQKLQQRHSTYNNNNGNSRKDKRNSQYNSDSSAPKSSDDEA 622
                         .|.|..:.:.:                       |..::|.||||.||::|.
Mosquito   372 -------------RPDSCSEVKYI-----------------------NQNFSSGSSAPISSEEED 400

  Fly   623 DIDEEVEQQPLPVPQAPVQSASQPAAGLNSPDSISDDLVRPLPPQLQRSPRKLTVAPAEHNKRQP 687
            :.:||.|...:|              .||||||||||||:.||  |::||.| |..| :..||.|
Mosquito   401 NDEEEDELSKIP--------------ELNSPDSISDDLVQALP--LRQSPIK-TTGP-DTAKRNP 447

  Fly   688 SPYYYSDLLKSRDKDKDKDKDKDKDKDKDKDKDKDKDKERDKDREDFKLKCRQSTAS------EP 746
            ||||||||||::.::::..:....|.....:                 |...|.|.:      :|
Mosquito   448 SPYYYSDLLKNKQREREGTELIPADTGLPAN-----------------LPTVQQTPTAEAVRRDP 495

  Fly   747 PQQTQTQLGGYRKSSSLDVPPAEEQPEAESHEEEDPRTGQDSQSTPKRYSFTEEGVHIIRCETPS 811
            |.:       |:||||||.|.|         |:|.|        .|||||.|||||.||||::||
Mosquito   496 PVR-------YKKSSSLDTPGA---------EKEVP--------LPKRYSITEEGVRIIRCDSPS 536

  Fly   812 TSTSEESDCSECLKRREWHARALALVRKTCNVQPRNQNPTGSELQLQLQHCDAGEGELLKCCPPP 876
            |:||::||||||.|||.|.|:|||:.|.|||:.||                              
Mosquito   537 TTTSDDSDCSECCKRRAWQAQALAITRATCNLGPR------------------------------ 571

  Fly   877 PAPAENQSQVQPMPPHRLLGPAAVCGACITSAPASSLAGGRGSELGDDLEEEYFRPRSIFYVHPH 941
                     |..||||||||||||| ||.|......         .||.::|.||||||||||..
Mosquito   572 ---------VDSMPPHRLLGPAAVC-ACATPQAFGD---------DDDNDDELFRPRSIFYVHQP 617

  Fly   942 GVHECIECAQPAQPATVPAPTLSNPSLDIYGDDEDEVDGDEDEDEEDDSEDIMGS-RRRQIYETA 1005
            |..:|.:||                           :.|..|......::|.|.: |.|||||||
Mosquito   618 GAADCADCA---------------------------LGGAGDLQSSTPAQDEMANVRTRQIYETA 655

  Fly  1006 FDCKIAKSDDDLDEVDRITNCSVLLQLSNGNGGDISK-VTGSSKTRAECKRAKNSKNQALQEQTG 1069
            ||.||.:|||||||||||||.||||||:..|....|. |||.:...:..||....:.::...:|.
Mosquito   656 FDSKITRSDDDLDEVDRITNQSVLLQLTKSNSSSASNMVTGGAPPASRTKRLDTKRTKSASSKTP 720

  Fly  1070 EAHVQ-VHHVEAELGKLQLSQVDQQNQNQNQSQNQQHGVSATGSGASASSTQQLPVRGYTPSPPS 1133
            ....| :...:..|.:.:..|:.|..|.:.|...|...:    :.|:::|:.|||:.||||||||
Mosquito   721 SGGGQDIAGAQPALEEAKADQLAQDLQEKLQLDKQMDNI----ANANSTSSSQLPLWGYTPSPPS 781

  Fly  1134 TAPLPMKFPGKHDRYLNMNSIRSAPNLPAANPA--HPRLRDLRLPIQSMRHQ--CGGSSNDNSLT 1194
            ||||||||||||:|:. ::||:||||||::|..  ||||:||||.||::|:.  .||||.|.|:.
Mosquito   782 TAPLPMKFPGKHERFF-ISSIKSAPNLPSSNAGAQHPRLKDLRLDIQNVRNNDGAGGSSCDGSIA 845

  Fly  1195 DSAYVNPPSTNSNSNAASASASASVSATGSAAPRRPRS-FVLESGRVLELRRSAQGHQGGQSTHH 1258
            :.|    |..:                 ||....|||| ..||..|||||:|   ||:|  ::||
Mosquito   846 EGA----PFGH-----------------GSKVGERPRSTLCLEPERVLELKR---GHRG--ASHH 884

  Fly  1259 HHHHHHHAPGSRRNRHGQSQGQTTGGGHNYSSTESIATSSSGGSMESLRSSTSEGNRSTSSSESR 1323
            ||       |.::::.|:.         |:|||||:||||||||||||:|||||||||||||:||
Mosquito   885 HH-------GKQQHQRGRG---------NFSSTESMATSSSGGSMESLKSSTSEGNRSTSSSDSR 933

  Fly  1324 HSSSLSSHSSESGSGGSGGSGGSSVAYPLRPAPLLLHSKLHILSPISDKSSQEPASASAS-EQSQ 1387
            ||||||||||:|         |.|:|:||| .|:.:|:||:|||||||||||||.|.::. ....
Mosquito   934 HSSSLSSHSSDS---------GPSLAFPLR-VPVAIHNKLNILSPISDKSSQEPGSETSDINNRN 988

  Fly  1388 QPSQQLAPMASQEDDSTTSGAPA-------------------GNQVQVNASLKQPRSNRGAPNKA 1433
            ..||:.:|:     |.||.|..|                   |..|...|........|.|||||
Mosquito   989 NNSQKQSPV-----DGTTGGGGAVAGGGSGTLSKKEGEESAGGGVVGTEAVKTNVTKRRSAPNKA 1048

  Fly  1434 LLQL-ADELLGSDSGISLHSREDGKPQA----LALQRLTLPKLQLIGAEGTTTSATASGAGGSSA 1493
            ||.: ..|:.|||||||||||||.|.:.    .:|||.:|                         
Mosquito  1049 LLLITGPEIQGSDSGISLHSREDLKSRTNFLNASLQRASL------------------------- 1088

  Fly  1494 TGGSSGAGGSGSGSVVASGSTGIQQDLRDLPFDMPKLRRRKTLQQEAACTSGSATSVDLGELPFD 1558
              |....|..|      .|.:|:.|||.||||||||||||:...|:..|||||.||||:|:||||
Mosquito  1089 --GQDKQGDHG------KGQSGLPQDLSDLPFDMPKLRRRRAHLQQEPCTSGSVTSVDVGDLPFD 1145

  Fly  1559 MPKLRRRLRANQAEINN---------------------------------LLMHSTESSGISQAS 1590
            |||||||||.:|.:.:.                                 ||..||||||:||||
Mosquito  1146 MPKLRRRLRLSQNQQHQQLLQQQQQQQQQHQLQQHPFQTSTAASTSGGGMLLQTSTESSGLSQAS 1210

  Fly  1591 SSHSMRD-DQKMSSKLDTALFRQNLTLNLNE-SRQATKQFGSLDLRGLNSNKELNMNLSQGYVTA 1653
            ||.|||| |.|::  |....|:|:||||||| .::..|:||:||| |||    |..|...     
Mosquito  1211 SSLSMRDSDSKLA--LAGGFFKQSLTLNLNECGQRPPKKFGTLDL-GLN----LGTNRPN----- 1263

  Fly  1654 VDLIDVTIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLKGAKGFMHMRIQ 1718
            |||||.:|||:|||||||:|:||:||..|||||||||||||.|||:|||||:||.||||||||||
Mosquito  1264 VDLIDASIPLDRQGWYHGSISRIDAEKILRPLSEGSFLVRNSESTRQDYSLTLKSAKGFMHMRIQ 1328

  Fly  1719 RN-ETGQYILGQFSRPFETVPEMIRHFCLNRLPVRGAEHMCLIEPVIAQLL 1768
            |: ::||:|||||||||.|:|:||||||||||||||||||||:||||||:|
Mosquito  1329 RDADSGQFILGQFSRPFPTIPDMIRHFCLNRLPVRGAEHMCLLEPVIAQIL 1379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hwtNP_001259484.1 SH2_SHB_SHD_SHE_SHF_like 1666..1763 CDD:198198 79/97 (81%)
hwtXP_061517846.1 None

Return to query results.
Submit another query.