Protein Alignment Rab40 and RAB1B

DIOPT Version :10

• Sequence 1: NP_727611.1
• Gene: Rab40 / 32195
• FlyBaseID: FBgn0030391
• Length: 265
• Species: Drosophila melanogaster
• Sequence 2: NP_112243.1
• Gene: RAB1B / 81876
• HGNCID: 18370
• Length: 201
• Species: Homo sapiens
• Alignment Length: 185
• Identity: 73/185 - (39%)
• Similarity: 106/185 - (57%)
• Gaps: 15/185 - (8%)

  Fly     4 MTKDYDYLLKVLLVGDSDVGKHEILSNL-EDPSTESPFCSGNDCTSHILQTVA--YKTTTILLEG 65
            |..:||||.|:||:|||.|||..:|... :|..|||           .:.|:.  :|..||.|:|
Human     1 MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTES-----------YISTIGVDFKIRTIELDG 54

  Fly    66 KRVKLQLWDTSGQGRFCTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLKEVDEHA-PGIPKVLV 129
            |.:|||:|||:||.||.||..||.|||.|||:|||:|::.|:..:.:||:|:|.:| ..:.|:||
Human    55 KTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKLLV 119

  Fly   130 GNRLHLAFKRQVAAKQAETYASRNNMSCFEISPLCNFNIRESFCELARMALHRNG 184
            ||:..|..|:.|....|:.:|....:...|.|.....|:.::|..:|.....|.|
Human   120 GNKSDLTTKKVVDNTTAKEFADSLGIPFLETSAKNATNVEQAFMTMAAEIKKRMG 174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab40	NP_727611.1	P-loop containing Nucleoside Triphosphate Hydrolases	6..265	CDD:476819	72/183 (39%)
		SOCS	192..234	CDD:470605
RAB1B	NP_112243.1	Rab1_Ypt1	7..172	CDD:206661	68/175 (39%)
		Switch 1. /evidence=ECO:0000269|PubMed:20064470, ECO:0007744|PDB:3JZA	30..45		5/25 (20%)
		Switch 2 region, required for interaction with REP1/CHM	64..83		12/18 (67%)
		Switch 2. /evidence=ECO:0000269|PubMed:20064470, ECO:0007744|PDB:3JZA	65..80		8/14 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..201		1/1 (100%)