Protein Alignment Rab40 and RAB12

DIOPT Version :10

• Sequence 1: NP_727611.1
• Gene: Rab40 / 32195
• FlyBaseID: FBgn0030391
• Length: 265
• Species: Drosophila melanogaster
• Sequence 2: NP_001020471.3
• Gene: RAB12 / 201475
• HGNCID: 31332
• Length: 340
• Species: Homo sapiens
• Alignment Length: 218
• Identity: 80/218 - (36%)
• Similarity: 119/218 - (54%)
• Gaps: 37/218 - (16%)

  Fly     9 DYLLKVLLVGDSDVGKHEILSNLEDPSTESPFCSGNDCTSHILQTVAYKTTTILLEGKRVKLQLW 73
            |:.|:|:::|...|||    ::|.:..|:..||..  |.|.:  .|.:|..|:.|.||:::||:|
Human   136 DFKLQVIIIGSRGVGK----TSLMERFTDDTFCEA--CKSTV--GVDFKIKTVELRGKKIRLQIW 192

  Fly    74 DTSGQGRFCTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLKEVDEHA-PGIPKVLVGNRLHLAF 137
            ||:||.||.:|..:|.|.|:|||||||||.|.:||.:.:|:|.:|::| .....:||||:|....
Human   193 DTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCET 257

  Fly   138 KRQVAAKQAETYASR-NNMSCFEISPLCNFNIRESFCELA-----RMALH--RNGMEHIWRSNKV 194
            .|::..:|.|.:|.: ..|...|.|...|||:.|.|.:|.     :|.|.  ||.:     ||.:
Human   258 DREITRQQGEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLDILRNEL-----SNSI 317

  Fly   195 LSLQ-------EL--------CC 202
            ||||       ||        ||
Human   318 LSLQPEPEIPPELPPPRPHVRCC 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab40	NP_727611.1	P-loop containing Nucleoside Triphosphate Hydrolases	6..265	CDD:476819	80/218 (37%)
		SOCS	192..234	CDD:470605	9/26 (35%)
RAB12	NP_001020471.3	Rab12	139..340	CDD:206699	77/213 (36%)