Protein Alignment Rab40 and RAB40A

DIOPT Version :10

• Sequence 1: NP_727611.1
• Gene: Rab40 / 32195
• FlyBaseID: FBgn0030391
• Length: 265
• Species: Drosophila melanogaster
• Sequence 2: NP_543155.2
• Gene: RAB40A / 142684
• HGNCID: 18283
• Length: 277
• Species: Homo sapiens
• Alignment Length: 283
• Identity: 162/283 - (57%)
• Similarity: 207/283 - (73%)
• Gaps: 29/283 - (10%)

  Fly     2 GTMTKDYDYLLKVLLVGDSDVGKHEILSNLEDPSTESPFCSGNDCTSHILQTVAYKTTTILLEGK 66
            |:..:.||:|||.|||||.||||.|||.:|:|.:.|||:       || |..:.||||||||:|:
Human     5 GSPDQAYDFLLKFLLVGDRDVGKSEILESLQDGAAESPY-------SH-LGGIDYKTTTILLDGQ 61

  Fly    67 RVKLQLWDTSGQGRFCTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLKEVDEHAPGIPKVLVGN 131
            ||||:|||||||||||||.|||||||||:||||||.|:|||:|:|||:|:::|||||:||:||||
Human    62 RVKLKLWDTSGQGRFCTIFRSYSRGAQGVILVYDIANRWSFEGMDRWIKKIEEHAPGVPKILVGN 126

  Fly   132 RLHLAFKRQVAAKQAETYASRNNMSCFEISPLCNFNIRESFCELARMALHRNGMEHIWRSNKVLS 196
            ||||||||||..:||:.||.|..::.||:||||||||.|||.||||:.|.|:.|..:.|.:||||
Human   127 RLHLAFKRQVPREQAQAYAERLGVTFFEVSPLCNFNIIESFTELARIVLLRHRMNWLGRPSKVLS 191

  Fly   197 LQELCCRTIVRRTSVYAIDSLPLPPSVKSTLKSYALTTSQCFN---------SLTQSSKSKNR-C 251
            ||:|||||||..|.|:.:|.||||.:::|.|||:::  ::..|         |||.||..|:. |
Human   192 LQDLCCRTIVSCTPVHLVDKLPLPSTLRSHLKSFSM--AKGLNARMMRGLSYSLTTSSTHKSSLC 254

  Fly   252 KT---------PTSSSRNSCAIA 265
            |.         |.:.:||||.|:
Human   255 KVEIVCPPQSPPKNCTRNSCKIS 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab40	NP_727611.1	P-loop containing Nucleoside Triphosphate Hydrolases	6..265	CDD:476819	160/277 (58%)
		SOCS	192..234	CDD:470605	24/41 (59%)
RAB40A	NP_543155.2	P-loop containing Nucleoside Triphosphate Hydrolases	9..277	CDD:476819	160/277 (58%)
		Switch-I. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753	41..49		5/15 (33%)
		Switch-II. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753	72..88		14/15 (93%)
		SOCS_Rab40	187..228	CDD:239711	24/42 (57%)