Protein Alignment Pkcdelta and SCH9

DIOPT Version :10

• Sequence 1: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0287828
• Length: 1894
• Species: Drosophila melanogaster
• Sequence 2: NP_012075.1
• Gene: SCH9 / 856612
• SGDID: S000001248
• Length: 824
• Species: Saccharomyces cerevisiae
• Alignment Length: 818
• Identity: 220/818 - (26%)
• Similarity: 349/818 - (42%)
• Gaps: 210/818 - (25%)

  Fly  1195 SPNKQQALQLQQQHEEQQRQQQQQATNA------------SSPAATGD----------ATTTPTT 1237
            |.|:......|.||...|......::.|            |.|.|:.:          .|.||||
Yeast     9 SSNQDTGFSSQHQHPNGQNNGNNNSSTAGNDNGYPCKLVSSGPCASSNNGALFTNFTLQTATPTT 73

  Fly  1238 ITIGVAAVNVAAVAVVASAAAAAATDAAADATTSLSSNN------SCGEG---VGNNLSKFATVS 1293
                                 |.:.|..|..||.::|.|      |...|   |.||.|...|:.
Yeast    74 ---------------------AISQDLYAMGTTGITSENALFQMKSMNNGISSVNNNNSNTPTII 117

  Fly  1294 NLAQCLRDVDAELDDYIPSSAENSQEDDDDDDDGSGSSSDDYSSVDGCANLSASMKKKLRKEKKK 1358
            ..:|...:......|...:|.:||      :||...|||.....:...::||.:.:
Yeast   118 TTSQEETNAGNVHGDTGGNSLQNS------EDDNFSSSSTTKCLLSSTSSLSINQR--------- 167

  Fly  1359 QKAKAAAAAEAKRFD-PHKKIKIDTTNKCYVKEEAPRYPLVATPRPLWKREK-----IVYSDENT 1417
               :|||||.....| |..|:::                .:...|.|..|.|     :|.:.|::
Yeast   168 ---EAAAAAYGPDTDIPRGKLEV----------------TIIEARDLVTRSKDSQPYVVCTFESS 213

  Fly  1418 DDESGSEEGSGGSLDEDSDDESGGE---------ECSSTSSSASS------------------ED 1455
            :..|...| |.|:::.::::.:..:         ...:|:..|:|                  |.
Yeast   214 EFISNGPE-SLGAINNNNNNNNNNQHNQNQHINNNNENTNPDAASQHHNNNSGWNGSQLPSIKEH 277

  Fly  1456 LDAVAMVTKAGSSNATTVLDSSNSSGSNAGTLSVPS-----AGSGSGGGASTSSSPSI------- 1508
            |....:.|...||.    ||..||..|    ::.||     :.|||..|....||..|
Yeast   278 LKKKPLYTHRSSSQ----LDQLNSCSS----VTDPSKRSSNSSSGSSNGPKNDSSHPIWHHKTTF 334

  Fly  1509 ----------IRMSTCSNDSGFEG---------GTAPSS--------PKKMLET-------SYTY 1539
                      |.:...::|..|.|         ..|.:|        |:.:.|.       .:||
Yeast   335 DVLGSHSELDISVYDAAHDHMFLGQVRLYPMIHNLAHASQHQWHSLKPRVIDEVVSGDILIKWTY 399

  Fly  1540 SQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLE 1604
            .|.:|              ::|...||..|.:||||:||:|...:.:||...||:|.|.|.|:::
Yeast   400 KQTKK--------------RHYGPQDFEVLRLLGKGTFGQVYQVKKKDTQRIYAMKVLSKKVIVK 450

  Fly  1605 DDDVDSTLIERKVL--ALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERA 1667
            .:::..|:.||.:|  ......|::..|..:|||.:.|:.|.:|::||:|.:|:|:.|||||:||
Yeast   451 KNEIAHTIGERNILVTTASKSSPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRA 515

  Fly  1668 RFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYM 1732
            :||.||::..|:.||...|:|||||.:|:|||..|::.:.|||:.|..: .|:| ::||||.:|:
Yeast   516 KFYIAELVLALEHLHDNDIVYRDLKPENILLDANGNIALCDFGLSKADL-KDRT-NTFCGTTEYL 578

  Fly  1733 APEIIKGEK-YNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFP-VYISAEATGI 1795
            |||::..|. |.:.||:||.|||::||..|.|||...:..:::..|......|| ..:|.|....
Yeast   579 APELLLDETGYTKMVDFWSLGVLIFEMCCGWSPFFAENNQKMYQKIAFGKVKFPRDVLSQEGRSF 643

  Fly  1796 LKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFT- 1859
            :||||.::...|:|: .....::..|.||..|||..|::::|.|||||.:....||..||..||
Yeast   644 VKGLLNRNPKHRLGA-IDDGRELRAHPFFADIDWEALKQKKIPPPFKPHLVSETDTSNFDPEFTT 707

  Fly  1860 ---------RERVRLTPIDKEILASMDQKQFHGFTYTN 1888
                     :..:..||:...:     |.:|.|||:.:
Yeast   708 ASTSYMNKHQPMMTATPLSPAM-----QAKFAGFTFVD 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	Herpes_BLLF1	<802..1131	CDD:282904
		STKc_nPKC_theta_like	1570..1889	CDD:270744	123/333 (37%)
SCH9	NP_012075.1	YPK1_N_like	181..407	CDD:212165	46/264 (17%)
		STKc_Sck1_like	418..738	CDD:270738	122/327 (37%)