Protein Alignment Pkcdelta and YPK2

DIOPT Version :10

• Sequence 1: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0287828
• Length: 1894
• Species: Drosophila melanogaster
• Sequence 2: NP_013822.1
• Gene: YPK2 / 855130
• SGDID: S000004710
• Length: 677
• Species: Saccharomyces cerevisiae
• Alignment Length: 637
• Identity: 190/637 - (29%)
• Similarity: 301/637 - (47%)
• Gaps: 97/637 - (15%)

  Fly  1307 DDYIPSSAENSQ-EDDDDDDDGSGSSSDDYSSVDGCANLSASMKKKLRKEKKKQKAKAAAAAEAK 1370
            ::.:|||..:.: .:|....:.||..:|         |..||.:|             |:.:..:
Yeast    64 NETLPSSLSSPKLRNDASFKNPSGIGND---------NSKASERK-------------ASQSSTE 106

  Fly  1371 RFDPHKKIKIDTTNKCYVKEEAPRYPLVATPRPLWKREKIVYSDENTDDESGSEEGSG------- 1428
            ...|..:..:.|......|:....:|:.:....|   :|::.|...|...:.:.|.:.
Yeast   107 TQGPSSESGLMTVKVYSGKDFTLPFPITSNSTIL---QKLLSSGILTSSSNDASEVAAIMRQLPR 168

  Fly  1429 -GSLDEDSDDESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVL-------DSSNSSGSNAG 1485
             ..:|:||..|...:...:|....||        :...||:|::.:|       :|..:...:.|
Yeast   169 YKRVDQDSAGEGLIDRAFATKFIPSS--------ILLPGSTNSSPLLYFTIEFDNSITTISPDMG 225

  Fly  1486 T-------------------------------LSVPSAGSGSGGGASTSSSPSIIRMSTCSNDSG 1519
            |                               |.:||.......|........|::....:.|..
Yeast   226 TMEQPVFNKISTFDVTRKLRFLKIDVFARIPSLLLPSKNWQQEIGEQDEVLKEILKKINTNQDIH 290

  Fly  1520 FEGGTAP------SSPKKMLETSYTYSQFQKSGRFTAPATVIP-RFKNYSVDDFHFLAVLGKGSF 1577
            .:....|      |:.:..|...:..|..:..|:........| :.|..|:|||..|.|:|||||
Yeast   291 LDSFHLPLNLKIDSAAQIRLYNHHWISLERGYGKLNITVDYKPSKNKPLSIDDFDLLKVIGKGSF 355

  Fly  1578 GKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFF 1642
            |||:....:||...||:|.|:|..::...:|..||.||.||| ....|::..|..:||:...|:.
Yeast   356 GKVMQVRKKDTQKIYALKALRKAYIVSKCEVTHTLAERTVLA-RVDCPFIVPLKFSFQSPEKLYL 419

  Fly  1643 VMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIA 1707
            |:.::|||:|.:|:|..||||..|:|||.||::..|..|||..:||||||.:|:||||:||:.:.
Yeast   420 VLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDVIYRDLKPENILLDYQGHIALC 484

  Fly  1708 DFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDE 1772
            |||:|||.:..:...|:|||||:|:||||:.|:.|.:.||||:.|:|||||:.|..|:...:...
Yeast   485 DFGLCKLNMKDNDKTDTFCGTPEYLAPEILLGQGYTKTVDWWTLGILLYEMMTGLPPYYDENVPV 549

  Fly  1773 LFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQI 1837
            ::..|..:...||......|..:|.|||.:|.::|:|  .:...:|.:|.||:.|.|..|..:..
Yeast   550 MYKKILQQPLLFPDGFDPAAKDLLIGLLSRDPSRRLG--VNGTDEIRNHPFFKDISWKKLLLKGY 612

  Fly  1838 EPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDK---EILASMDQKQFHGFTY 1886
            .||:||.||..:||..||:.||:|:    |||.   |.|::..||||.|:||
Yeast   613 IPPYKPIVKSEIDTANFDQEFTKEK----PIDSVVDEYLSASIQKQFGGWTY 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	Herpes_BLLF1	<802..1131	CDD:282904
		STKc_nPKC_theta_like	1570..1889	CDD:270744	137/320 (43%)
YPK2	NP_013822.1	YPK1_N_like	114..339	CDD:212165	35/235 (15%)
		Protein Kinases, catalytic domain	349..660	CDD:473864	135/317 (43%)