Protein Alignment Pkcdelta and PKC1

DIOPT Version :10

• Sequence 1: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0287828
• Length: 1894
• Species: Drosophila melanogaster
• Sequence 2: NP_009445.2
• Gene: PKC1 / 852169
• SGDID: S000000201
• Length: 1151
• Species: Saccharomyces cerevisiae
• Alignment Length: 815
• Identity: 227/815 - (27%)
• Similarity: 356/815 - (43%)
• Gaps: 220/815 - (26%)

  Fly  1098 ATLVP-----QTETKTKLTEAAEPTGKSKVQSPNTTKPKSAGKTNVGKKKAATPAAAAAAAAAAA 1157
            |.|||     ..|...|:.:..:.|                 |.|..|||...|:|...::...|
Yeast   524 AHLVPDFCGMSMEMANKILKTIQDT-----------------KRNQEKKKRTVPSAQLGSSIGTA 571

  Fly  1158 PAAATATEAVTALSESNVTPINADQFITLAPTKAAKTSPNKQ------QALQLQQQHEEQQR--- 1213
            ..:..:...:...:.:.:.|.......|.:|.|..:.||.||      :.:.||....|:..
Yeast   572 NGSDLSPSKLAERANAPLPPQPRKHDKTPSPQKVGRDSPTKQHDPIIDKRISLQTHGREKLNKFI 636

  Fly  1214 ----------QQQQQATNASSPAATGDATTTPTTITIGVAAVNVAAVAVVASAAAAAATDAAADA 1268
                      :..||....|||..|.|.|:...::.:
Yeast   637 DENEAYLNFTEGAQQTAEFSSPEKTLDPTSNRRSLGL---------------------------- 673

  Fly  1269 TTSLSSNNSCGEGVGNNLSKFATVSNLAQCLRDVDAELDDYIPSSAENSQEDDDDDDDGSGSSSD 1333
             |.||..:|            .|..:....:||   ||:.:.....|...|...|    ||...:
Yeast   674 -TDLSIEHS------------QTWESKDDLMRD---ELELWKAQREEMELEIKQD----SGEIQE 718

  Fly  1334 DYSSVDGCANLSASMKKKLRKEKKKQKAKAAAAAEAKRFDPHKKIKIDTTNKCYVKEEAPRYPLV 1398
            |. .||   ::....|:||..|.|....:|....::...:|.:.:..:|.
Yeast   719 DL-EVD---HIDLETKQKLDWENKNDFREADLTIDSTHTNPFRDMNSETF--------------- 764

  Fly  1399 ATPRPLWKREKIVYSDENTDDESGSEEGSGGSLDEDSDDESGGEECSSTSSSASSEDLDAVAMVT 1463
                                              :...|.:..|....|.|.|.:
Yeast   765 ----------------------------------QIEQDHASKEVLQETVSLAPT---------- 785

  Fly  1464 KAGSSNATTVLDSSNSSGSNAGTLSVPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSS 1528
               |::|:...|.                                                  .|
Yeast   786 ---STHASRTTDQ--------------------------------------------------QS 797

  Fly  1529 PKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYA 1593
            |:|        ||...|.:....|.   :.:..|:|:|..|.|||||:||||:|::.::|....|
Yeast   798 PQK--------SQTSTSAKHKKRAA---KRRKVSLDNFVLLKVLGKGNFGKVILSKSKNTDRLCA 851

  Fly  1594 IKCLKKDVVLEDDDVDSTLIERKV--LALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHI 1656
            ||.||||.::::.|::|...|:||  ||..||||:|.:|:|:||||:.::|.||::.|||||:|:
Yeast   852 IKVLKKDNIIQNHDIESARAEKKVFLLATKTKHPFLTNLYCSFQTENRIYFAMEFIGGGDLMWHV 916

  Fly  1657 QESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKT 1721
            |.. |.|..||:||.||::..||:.|..|:|||||||:|:||..|||::|||:|:||.:::....
Yeast   917 QNQ-RLSVRRAKFYAAEVLLALKYFHDNGVIYRDLKLENILLTPEGHIKIADYGLCKDEMWYGNR 980

  Fly  1722 ADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPV 1786
            ..:|||||::|||||:|.::|.:.||||:||||||:||:.||||||.||||:|.:|..:.|.:|:
Yeast   981 TSTFCGTPEFMAPEILKEQEYTKAVDWWAFGVLLYQMLLCQSPFSGDDEDEVFNAILTDEPLYPI 1045

  Fly  1787 YISAEATGILKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDT 1851
            .::.|...|.:|||.||..||:|:....|.::.:..|||.|::..:...:::||:.|::|.|.||
Yeast  1046 DMAGEIVQIFQGLLTKDPEKRLGAGPRDADEVMEEPFFRNINFDDILNLRVKPPYIPEIKSPEDT 1110

  Fly  1852 QYFDRVFTRERVRLTPIDKEILASMDQKQFHGFTY 1886
            .||::.||.....|||: ..:|.:..|::|.||::
Yeast  1111 SYFEQEFTSAPPTLTPL-PSVLTTSQQEEFRGFSF 1144

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	Herpes_BLLF1	<802..1131	CDD:282904	7/37 (19%)
		STKc_nPKC_theta_like	1570..1889	CDD:270744	149/319 (47%)
PKC1	NP_009445.2	HR1_PKC-like_1_fungi	1..72	CDD:212011
		HR1_PKC-like_2_fungi	110..181	CDD:212010
		C2_fungal_Pkc1p	211..319	CDD:176071
		C1_ScPKC1-like_rpt1	413..464	CDD:410372
		C1_ScPKC1-like_rpt2	478..536	CDD:410373	4/11 (36%)
		STKc_PKC	828..1145	CDD:270722	149/319 (47%)