Protein Alignment Pkcdelta and PRKCA

DIOPT Version :10

• Sequence 1: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0287828
• Length: 1894
• Species: Drosophila melanogaster
• Sequence 2: NP_002728.2
• Gene: PRKCA / 5578
• HGNCID: 9393
• Length: 672
• Species: Homo sapiens
• Alignment Length: 647
• Identity: 243/647 - (37%)
• Similarity: 327/647 - (50%)
• Gaps: 110/647 - (17%)

  Fly  1298 CLRDVDAELDDYIPSSAENSQEDDDDDDD-----------GSGSSSDDYSSV------DG--CAN 1343
            |...|.....:::..|...:.:..|.||.           ||.:..|...|:      .|  |..
Human    70 CCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDT 134

  Fly  1344 LSASMKKKL-----------RKEKKKQ---KAKAA------AAAEAKRF---------DPHKKIK 1379
            ...::.|:.           ..||:.:   ||:.|      ...:||..         ||:.|:|
Human   135 CDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLK 199

  Fly  1380 I--DTTNKCYVKEEAPRYPLVATPRPLWKRE---KIVYSDENTDDESGSEEGSGGSLDEDSDDES 1439
            :  |..|:...|.:..|    :|..|.|...   |:..||:   |...|.|      ..|.|..:
Human   200 LIPDPKNESKQKTKTIR----STLNPQWNESFTFKLKPSDK---DRRLSVE------IWDWDRTT 251

  Fly  1440 GGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLDSSNSSGSNAGTLSVPSAGSGSGGGASTSS 1504
            ..:...|.|...|.        :.|..:|....:|:.......|     ||.......|......
Human   252 RNDFMGSLSFGVSE--------LMKMPASGWYKLLNQEEGEYYN-----VPIPEGDEEGNMELRQ 303

  Fly  1505 SPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFL 1569
            .....::....|..     .:||..:|.                  |:..:.|.|   :.||:||
Human   304 KFEKAKLGPAGNKV-----ISPSEDRKQ------------------PSNNLDRVK---LTDFNFL 342

  Fly  1570 AVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTF 1634
            .||||||||||:||:.:.|...||||.||||||::||||:.|::|::||||..|.|:|..|...|
Human   343 MVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCF 407

  Fly  1635 QTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLD 1699
            ||...|:|||||:||||||:|||:.|:|.|.:|.||.|||..||.||||:||||||||||||:||
Human   408 QTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD 472

  Fly  1700 YEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSP 1764
            .|||::||||||||..:....|..:|||||||:|||||..:.|.::||||::||||||||.||.|
Human   473 SEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPP 537

  Fly  1765 FSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAG--DIADHIFFRPI 1827
            |.|.||||||.||......:|..:|.||..:.|||:.|...||:|.  .|.|  |:.:|.|||.|
Human   538 FDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGC--GPEGERDVREHAFFRRI 600

  Fly  1828 DWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDKEILASMDQKQFHGFTYTNP 1889
            ||..||.|:|:|||||:|... ..:.||:.|||.:..|||.|:.::|::||..|.||:|.||
Human   601 DWEKLENREIQPPFKPKVCGK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	Herpes_BLLF1	<802..1131	CDD:282904
		STKc_nPKC_theta_like	1570..1889	CDD:270744	181/320 (57%)
PRKCA	NP_002728.2	C1_cPKC_rpt1	35..92	CDD:410383	3/21 (14%)
		C1_cPKC_rpt2	102..155	CDD:410386	7/52 (13%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	31/155 (20%)
		STKc_cPKC_alpha	328..668	CDD:270766	189/340 (56%)