Protein Alignment Pkcdelta and aPKC

DIOPT Version :10

• Sequence 1: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0287828
• Length: 1894
• Species: Drosophila melanogaster
• Sequence 2: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Alignment Length: 1074
• Identity: 280/1074 - (26%)
• Similarity: 382/1074 - (35%)
• Gaps: 373/1074 - (34%)

  Fly  1050 KSPEQQQATAAAVETKINKTTDKEQQQQQQQQQQQQAQQQQQQLIDTAATLVPQTETKTKLTEAA 1114
            :||.:....|......:.:..::||....||||.||.|||||.          ||
  Fly    15 RSPRRLTQCAPLPVNIVQQEEEEEQPCLPQQQQHQQTQQQQQS----------QT---------- 59

  Fly  1115 EPTGKSKVQSPNTTKPKSAGKTNV-----GKKKAATPAAAAAAAAAAAPAAATATEAVTALSESN 1174
                     .|:|......|..|:     .:.:.::|...:...:...|.....|.:...|..:.
  Fly    60 ---------CPSTPSANQQGSGNLCYSPTCRSRCSSPCPGSPCGSITPPPPPMLTSSQQHLHSNK 115

  Fly  1175 VTPINADQFITLAPTKAAKTSPNKQQALQLQQQHEEQQRQQQQQATNASSPAATGDATTTPTTIT 1239
            ..|. |.|.:|.....|.:.|        |.|....|.:....||...|.....|
  Fly   116 NCPA-AQQLMTHLDYAARRQS--------LDQLDSPQSKYFDIQANQLSDIMCRG---------- 161

  Fly  1240 IGVAAVNVAAVAVVASAAAAAATDAAADATTSLSSNNSCGEGVGNNLSKFATVSNLAQCLRDVDA 1304
                       |||:|..               |:||:...||..:...
  Fly   162 -----------AVVSSIQ---------------SANNTLTRGVSMHSRS---------------- 184

  Fly  1305 ELDDYIPSSAENSQEDDDDDDDGSGSSSDDYSSVDGCANL--------SASMKKKLRKEKKKQKA 1361
                   .||..|...........||:......:.|...:        |..|
  Fly   185 -------GSAHGSHHGSHHSHSHHGSAHGSLGCLQGGVGVGVGTGSTGSIGM------------- 229

  Fly  1362 KAAAAAEAKRFD-PHKKIKIDTTNKCYVKEEAPRYPLVATPRPLWKREKIVYSDENTDDESGSEE 1425
            .:|...:...:| ||                         |.|.........:.......|.|..
  Fly   230 MSAGHIDTGDYDVPH-------------------------PHPYTHHYMQTTASVTPPHTSLSRP 269

  Fly  1426 GSGGSL----DEDSDDESG---------------GEECSSTSSSASSEDLDAVAMVTKAGSSNAT 1471
            ||.|::    |..||...|               |...|....||.|..|...:  ::..::|.|
  Fly   270 GSAGAVCQGHDSGSDSSQGCGGSIMGGMLVMGHPGHMGSLGHHSAGSGSLGRCS--SRCHNTNTT 332

  Fly  1472 TVLDS---SNSSGSNAGTLS-------VP-------------SAGSGSGG-------GASTSSSP 1506
            |..||   |:..|...||:|       :|             |||||..|       |.|.....
  Fly   333 TTDDSGGGSSGGGGVPGTMSSASMAVGMPGMLMDYHHSHHSGSAGSGLNGCGGGSIAGGSIGGRS 397

  Fly  1507 SIIRMSTCSNDSGFEG------------------------GTAPSS---------PKKMLETSY- 1537
            |:  :.|..|..|...                        |.||||         .::.:|.:|
  Fly   398 SV--LGTIHNGHGHHHQQYHHECIHYERLPIPVPIPTVPMGVAPSSQQMSQHQLQSEEEIEPAYA 460

  Fly  1538 ---------------------------------------------------TYSQ---------- 1541
                                                               .|.|
  Fly   461 TVFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQG 525

  Fly  1542 -----------------FQK-----------------SGRFTAPATVIP---------------- 1556
                             .||                 |.....|...:|
  Fly   526 FKCIQCKLLVHKKCHKLVQKHCTDQPEPLVKERAEESSDPIPVPLPPLPYEAMSGGAEACETHDH 590

  Fly  1557 ----------------RFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLED 1605
                            ..:.||::||..:.|:|:||:.|||:.|||.|...||:|.:||.:|.:|
  Fly   591 AHIVAPPPPEDPLEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDD 655

  Fly  1606 DDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFY 1670
            :|:|....|:.|....:.||:|..|...|||.|.||||:|::.|||||:|:|...|..||.||||
  Fly   656 EDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFY 720

  Fly  1671 GAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPE 1735
            .|||...|.|||:||||||||||||||||:|||:::.|:||||..|....|..:|||||:|:|||
  Fly   721 AAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPE 785

  Fly  1736 IIKGEKYNQNVDWWSFGVLLYEMLIGQSPF--SGCD-------EDELFWSICNEIPWFPVYISAE 1791
            |::||.|..:||||:.||||||||.|:|||  :|..       ||.||..|..:....|..:|..
  Fly   786 ILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVR 850

  Fly  1792 ATGILKGLLEKDYTKRIGSQYSPA-GDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFD 1855
            |..:|||.|.|:...|:|.....| .||..|.||:.:||.|||::|:.|||||::....|...|.
  Fly   851 AASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFP 915

  Fly  1856 RVFTRERVRLTPIDKEILASMDQKQFHGFTYTNP 1889
            ..||.|.|:|||.|..::.::||.:|.||.|.||
  Fly   916 PEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNP 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	Herpes_BLLF1	<802..1131	CDD:282904	20/80 (25%)
		STKc_nPKC_theta_like	1570..1889	CDD:270744	160/328 (49%)
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	4/53 (8%)
		STKc_aPKC	620..947	CDD:270740	159/326 (49%)