Protein Alignment Pkcdelta and Prkca

DIOPT Version :10

• Sequence 1: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0287828
• Length: 1894
• Species: Drosophila melanogaster
• Sequence 2: XP_036012317.1
• Gene: Prkca / 18750
• MGIID: 97595
• Length: 688
• Species: Mus musculus
• Alignment Length: 539
• Identity: 226/539 - (41%)
• Similarity: 295/539 - (54%)
• Gaps: 76/539 - (14%)

  Fly  1373 DPHKKIKI--DTTNKCYVKEEAPRYPLVATPRPLWKRE---KIVYSDENTDDESGSEEGSGGSLD 1432
            ||:.|:|:  |..|:...|.:..|    :|..|.|...   |:..||:   |...|.|      .
Mouse   193 DPYVKLKLIPDPKNESKQKTKTIR----STLNPQWNESFTFKLKPSDK---DRRLSVE------I 244

  Fly  1433 EDSDDESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLDSSNSSGSNAGTLSVPSAGSGSG 1497
            .|.|..:..:...|.|...|.        :.|..:|....:|:.......|     ||.......
Mouse   245 WDWDRTTRNDFMGSLSFGVSE--------LMKMPASGWYKLLNQEEGEYYN-----VPIPEGDEE 296

  Fly  1498 GGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYS 1562
            |...........::....|..     .:||..:|.                  |:..:.|.|
Mouse   297 GNMELRQKFEKAKLGPAGNKV-----ISPSEDRKQ------------------PSNNLDRVK--- 335

  Fly  1563 VDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYL 1627
            :.||:||.||||||||||:||:.:.|...||||.||||||::||||:.|::|::||||..|.|:|
Mouse   336 LTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFL 400

  Fly  1628 CHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLK 1692
            ..|...|||...|:|||||:||||||:|||:.|:|.|.:|.||.|||..||.||||:||||||||
Mouse   401 TQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLK 465

  Fly  1693 LDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYE 1757
            ||||:||.|||::||||||||..:....|..:|||||||:|||||..:.|.::||||::||||||
Mouse   466 LDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYE 530

  Fly  1758 MLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAG--DIAD 1820
            ||.||.||.|.||||||.||......:|..:|.||..|.|||:.|...||:|.  .|.|  |:.:
Mouse   531 MLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGC--GPEGERDVRE 593

  Fly  1821 HIFFRPIDWGLLEKRQIEPPFKPQV-----KHPLD----------TQYFDRVFTRERVRLTPIDK 1870
            |.|||.|||..||.|:|:|||||:|     .|.|.          .:.||:.|||.:..|||.|:
Mouse   594 HAFFRRIDWEKLENREIQPPFKPKVTFCTKMHWLQWASRPSCGKGAENFDKFFTRGQPVLTPPDQ 658

  Fly  1871 EILASMDQKQFHGFTYTNP 1889
            .::|::||..|.||:|.||
Mouse   659 LVIANIDQSDFEGFSYVNP 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	Herpes_BLLF1	<802..1131	CDD:282904
		STKc_nPKC_theta_like	1570..1889	CDD:270744	184/335 (55%)
Prkca	XP_036012317.1	C1_cPKC_rpt1	35..92	CDD:410383
		C1_cPKC_rpt2	102..155	CDD:410386
		C2_PKC_alpha_gamma	159..289	CDD:175992	26/121 (21%)
		STKc_cPKC_alpha	328..684	CDD:270766	192/355 (54%)