Protein Alignment Pkcdelta and pkn-1

DIOPT Version :10

• Sequence 1: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0287828
• Length: 1894
• Species: Drosophila melanogaster
• Sequence 2: NP_001360642.1
• Gene: pkn-1 / 181244
• WormBaseID: WBGene00009793
• Length: 1137
• Species: Caenorhabditis elegans
• Alignment Length: 864
• Identity: 233/864 - (26%)
• Similarity: 387/864 - (44%)
• Gaps: 184/864 - (21%)

  Fly  1181 DQFITLAPTKAAKTSPNKQQALQLQQQHEEQQRQQQQQATNASSPAATGDATTTPTTITIGVAAV 1245
            :||:..||.| :|...:.|..|...:......|.|.::.:. .:||..|:..|     .:.:|..
 Worm   298 EQFLRGAPDK-SKVHGDSQSLLDDSRAKIAMLRMQIERLSQ-EAPAVEGEPKT-----KVELAID 355

  Fly  1246 NVAAVAVVASAAAAAATDAAADATTSL-SSNNSCGEGVGNNLSKFATVSNLAQCLR--------D 1301
            ::    ::.........|.:.:....| |......:.|...::.:...|..|..::        .
 Worm   356 DL----IIRFHKEKLIMDGSRNMIRILRSKRKPDSKAVDEAMNSYVIASEKADLIKLALLKYASS 416

  Fly  1302 VDAELD--DYI-----------PSSAENSQEDDDDDDDGSGSSSD------DYS---------SV 1338
            :..|.|  .|:           |.|....:.....:|.|:|:|:.      .||         ::
 Worm   417 LPLEHDHRKYLIGEINSGLIPKPPSLSQDRNSPSSEDGGNGTSTSRRCSFMPYSLQISGCLEVTI 481

  Fly  1339 DGCAN-LSASMKKKLRKE-----------------KKKQKAKAAAAAEA--------KRF----- 1372
            :|||. ||...::|:||:                 |||:.|:...::|.        .||
 Worm   482 NGCAGILSEVFERKIRKDVPGVPGFISVYGMDASGKKKKSARGPNSSEEVFCVLRIDNRFIGATE 546

  Fly  1373 -----------------DPHKKIK----------------------IDTTNKC------------ 1386
                             |..::::                      |:|::|.
 Worm   547 LRKIVDRNWDQKFDVDLDRSRELQIELFYHDDRSMCGFAAVKLSNLIETSSKVGIIVPVEPQGNI 611

  Fly  1387 -----YVKEEAPRYPLVATPRPLWK--------REKI-VYSDENTDDESGSEEGSGGS------- 1430
                 |:.....|.|.:...|.|::        |:|: |::........|:|.....:
 Worm   612 FVQFKYMNPVVSRKPKLERQRRLFRVKESNDGARQKLGVFAFSRLIKNRGNEPSEKFAAFTGFTP 676

  Fly  1431 LDEDSDDESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLDSSNSSGSNAGTLSVPSAGSG 1495
            :...|.....|...|..|:|:|      :|......:||:.....|::....|....:.......
 Worm   677 MPSSSSQHQPGTSSSGPSTSSS------IASTPTPSTSNSLFDKVSNHLPSFNPRKSAKKREARE 735

  Fly  1496 SGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQF--QKSGRFTAPATVIPRF 1558
            :...|..:::.:.:.::..|..:..:    ||:.::.|    ...:|  .:||...||.....|.
 Worm   736 AAAVAPMTAAVAAVNLNAPSTSNSMQ----PSTQERNL----VVDEFPTDRSGPSQAPPVPAVRH 792

  Fly  1559 KNY---------SVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIE 1614
            .::         :|:.|..::|||:|.||||:|::...|:.|||:|.|||..:|..|:|:|.::|
 Worm   793 IDFFASSDGAPLTVEQFRLISVLGRGHFGKVILSQHNPTSNYYALKVLKKGDILGRDEVESLMVE 857

  Fly  1615 RKVLALGT--KHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISG 1677
            :::..:.:  :||:|.:|...|||..|:||.|||..|||||.||.:. .|.|.|..||.|.::.|
 Worm   858 KRIFEVSSRARHPFLVNLNGCFQTNEHVFFCMEYSMGGDLMRHIHDD-VFDEVRGCFYAACVVLG 921

  Fly  1678 LKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQI-YLDKTADSFCGTPDYMAPEIIKGEK 1741
            |.||||..|||||:||||:|||.||:|:|||||:||..: ..|||: :|||||:::|||::....
 Worm   922 LDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGLCKENMGPFDKTS-TFCGTPEFLAPEVLSDSS 985

  Fly  1742 YNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTK 1806
            |.:.:|||..|||::|||:|:.||||.||:|:|.||.:|...:|.|:|.|:..|::.||.|...|
 Worm   986 YTRAIDWWGLGVLIFEMLVGEPPFSGDDEEEIFDSIISEDVRYPRYLSVESIAIMRRLLRKVPEK 1050

  Fly  1807 RIGSQYSPAGDIADHIFFRPI--DWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPID 1869
            |:|.....|.||....|||.|  :|..|..|:|.|||:||:::|.|...||..||:|:.|.:...
 Worm  1051 RLGYGERDAEDIKIQRFFRHISWEWDKLLNREIRPPFQPQIRNPEDVSNFDLEFTQEKARFSAAS 1115

  Fly  1870 K-EILASMDQKQFHGFTYT 1887
            . ..:...||:.|:.|.::
 Worm  1116 STRPITEADQRLFNNFDFS 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	Herpes_BLLF1	<802..1131	CDD:282904
		STKc_nPKC_theta_like	1570..1889	CDD:270744	148/324 (46%)
pkn-1	NP_001360642.1	HR1_PKN_1	188..253	CDD:212012
		HR1_PKN_2	273..339	CDD:212013	10/42 (24%)
		HR1	344..410	CDD:469609	9/74 (12%)
		C2	527..>589	CDD:472691	4/61 (7%)
		STKc_PKN	809..1134	CDD:270741	149/326 (46%)