Protein Alignment Pkcdelta and Pkn

DIOPT Version :10

• Sequence 1: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0287828
• Length: 1894
• Species: Drosophila melanogaster
• Sequence 2: XP_061507643.1
• Gene: Pkn / 1269639
• VectorBaseID: AGAMI1_006873
• Length: 1377
• Species: Anopheles gambiae
• Alignment Length: 1841
• Identity: 402/1841 - (21%)
• Similarity: 638/1841 - (34%)
• Gaps: 652/1841 - (35%)

  Fly   228 SKDRSAESPKKEQVQEHQFRDLPPATEPSLSWRQKLAEELAAFPVTSNKKSPGELLRERFYIKDE 292
            |.:...:||:.:|.|:      .|.|:               |...|||         ...:||.
Mosquito     2 SINEQQQSPQPQQQQQ------SPPTD---------------FSFKSNK---------LVILKDL 36

  Fly   293 KEELTN--FNRAQIQELVQPQSAHKTLTPEVEISAKKEVDDEKEDESDKQEQELEEMQETIRR-- 353
            |.:|..  |:...|:..|..:.:||...|: .:|.:...|            .|||::|.|||
Mosquito    37 KAKLKGYLFSGDYIKHPVLYELSHKYGLPD-NVSEQLLPD------------RLEEIKEAIRREI 88

  Fly   354 ----------LSLVQCPTFHDICEDISSDKIDDDLNAGELRRRASIIQEQEQEILNKLQKSNSGS 408
                      ..|.:..|......|::|.....:....||:   |.:.|.|.:|:  |.:.||
Mosquito    89 RKELKIKEGAEKLREVATDRRSLSDVASIVKKSNNKLAELK---SELHELESQII--LTQGNS-- 146

  Fly   409 FQLIHLERRSSHD---ST--------TTNDEDLKERSKRRSKKSKKMRHKITAIVEVENAPQAQP 462
                 :.....||   ||        |.||:.|....|:.|.::|           |:|.
Mosquito   147 -----VSNNGGHDPILSTVIPSGPEFTANDKLLISLEKQLSIETK-----------VKNG----- 190

  Fly   463 VEHMPSVLELNEESLLIQPLTSGSGSSSTPTPSPKPKFTVNVETVEEHHQIHKIFKLPKKKTVPK 527
            .|:|            ||.::||.........:...:...:.:...|:.:: ||.|:.:.|...|
Mosquito   191 AENM------------IQSISSGHHGRDKKLLAEAHQMLADSKAKIEYLRL-KILKVRQNKLSSK 242

  Fly   528 DQDDSSLPEGFMKAAPKTTKTSPLKKVNKQQH--------VNEAQ--------IFTFDEAAIQQQ 576
            ..:::..........|:..:||...::.:.:|        |:.|:        ..|.|:.|:|:.
Mosquito   243 GSEENGGESANAAKQPQELETSLDDRIEELRHRLRIEAAVVDGAKNVIRTLQSTKTIDKKALQEA 307

  Fly   577 Q-----------------QVQQQQQQPELP---KTEAKVEGV--ATPKPI----RKAIQKSESGE 615
            |                 ::::.:..|:.|   :.:|:::.|  ::|.|:    |.:.:.|..|.
Mosquito   308 QGRLSESSRKLDLLRKALELRRLELPPDCPTAQQLKAELQNVQASSPGPVQYTMRNSFRGSAQGR 372

  Fly   616 DFWSQIGSRETLYMTNRKKVFNMRQEQQEQLLEEEPPKS-------PAMPKETKTDLKTPTT--- 670
            ...||........:|.:.:|   |....:.|||:.|.:|       .:.|.:.|:.:|..|:
Mosquito   373 PAHSQQSFSRCAAVTGKLEV---RLMGCQDLLEDVPGRSRRDKDAGSSSPGDLKSFVKGVTSRSS 434

  Fly   671 -------PKLKSEILIELK-TTPSIVSTSGKSETQKVPSTPLTPTVVKTNQVE------------ 715
                   .:..|||:..:| ...::..||.:..:|:......:..:.::.::|
Mosquito   435 SKSYSVKDETSSEIMAVIKLDNITVGQTSWRPCSQQAWDQRFSIDLDRSRELEIGVYWRDWRSLC 499

  Fly   716 ----AKKVESMD------TSSKAPASVI--------SKAAESPKLKSATDNNKAKPTMAKKDLPK 762
                .:..|.:|      .....|..|:        ...:..|||:      :.:....|:.:..
Mosquito   500 AVKFLRLEEFIDDIRHGMALQLEPQGVLFAEIKFLNPMISRKPKLQ------RQRMIFNKQQVKN 558

  Fly   763 LKTAEETKLTITT------KATTATPTMDSPKTPQAKEETSQKTESATTSQIKSDTPIALQIKPQ 821
            :..|::..:.:.|      :.||::.:...|.|..|....:....|||       .|:...:..|
Mosquito   559 IPRAKQMNINVATWGRLLKRNTTSSGSSSGPTTAGAAGAGTPSPGSAT-------VPMTGMMANQ 616

  Fly   822 EQMKVAAPTTPQAKVETPP-KDSPTRKIVAPTTPQAKVETPTKDSPTRKIV------------TP 873
            .|...|..|||.......| :|.|             ||| ..:|....:|            ..
Mosquito   617 TQHGSAGTTTPSTPGSYDPLQDDP-------------VET-LGESADHNVVGLGGGRPLGIHGVG 667

  Fly   874 TTPQAKVETPTKDSPTRKIVTPTTPQAKVETPTKDSPTRKIVTPTTPQAKVETPTKDSPTRKIA- 937
            ..|::......::..|..:..|..|...:.||:.....:|...|:..||   ||.|..|..:.|
Mosquito   668 VLPESPSSHSLQNQGTPMVGRPVPPPQSISTPSSFRQPKKQPMPSPRQA---TPPKIDPELEYAL 729

  Fly   938 -----------------------TPTTPQAKAAASTTSPLTTPQKTPQVK-----AATDESKSTP 974
                                   .|.||...:..:::..:.....|....     ...||....|
Mosquito   730 SKFDFLHQHDSLGGVSLYDKQPPLPVTPPPSSTVASSGYINNCDSTNNNNNNSNYIEDDEVPPLP 794

  Fly   975 AAPKTTMAKISMTTMAGTTVAEAGKTISPKGLKQSGNAVAMPTATPTTPNTPTTATG-------- 1031
            |.|...:...|..:.....:| ||.| ||..|::|   ::.....|.....|....|
Mosquito   795 ATPPPVLRSTSQISQPAGALA-AGAT-SPAVLQKS---LSGDLLRPVLSMPPPVLYGGGYNRDSY 854

  Fly  1032 KSKLNETAGPKINSGQPAKSPEQQQATAAAVETKINKTTDKEQQQQQQQQQQQQAQQQQQQL-ID 1095
            .|.::.|..|.:.. .|:.:|                          .|.|||.|...:..| .|
Mosquito   855 YSTVSSTGSPIVEE-PPSPAP--------------------------SQYQQQYAPFPEDDLTYD 892

  Fly  1096 TAATLVPQTETKTKLTEAAEPTGKSKVQSPNTTKPKSAGKTNVGKKKAATPAAAAAAAAAAAPAA 1160
            ....::|..:    ||     .|.:.|..|..........|.:.::        |:.|||||
Mosquito   893 NIIEILPFEQ----LT-----IGGNVVPPPLPPHHHHPSATLMSQQ--------ASLAAAAA--- 937

  Fly  1161 ATATEAVTALSESNVTPINADQFITLAPTKAAKTSPNKQQALQLQQQHE----EQQRQQQQQATN 1221
                             :.|.|               :||..|.|||.:    :||.|||||:.
Mosquito   938 -----------------LQAQQ---------------QQQLYQQQQQQQQLLLQQQLQQQQQSA- 969

  Fly  1222 ASSPAATGDATTTPTTITIGVAAVNVAAVAVVASAAAAAATDAAADATTSLSSNNSCGEGVGNNL 1286
                                     |...:::|...|||||
Mosquito   970 -------------------------VVPPSLLAQQHAAAAT------------------------ 985

  Fly  1287 SKFATVSNLAQCLRDVDAELDDYIPSSAENSQEDDDDDDDGSGSSSDDYSSVDGCANLSASMKKK 1351
                                                    |..|||       |..::.|
Mosquito   986 ----------------------------------------GQASSS-------GMVDVGA----- 998

  Fly  1352 LRKEKKKQKAKAAAAAEAKRFDPHKKIKIDTTNKCYVKEEAPRYPLVATPRPLWKREKIVYSDEN 1416
                     |..|......|                              ||
Mosquito   999 ---------ASGAVGPPVNR------------------------------RP------------- 1011

  Fly  1417 TDDESGSEEGSGGSLDEDSDDESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLDSSNSS- 1480
                                                           ..|.:.|....||:..|
Mosquito  1012 -----------------------------------------------AGGPARALQYRDSAYESR 1029

  Fly  1481 -GSNAGTLS-VPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQ 1543
             .|.||.:: .|.||                   .|
Mosquito  1030 RQSQAGAMAGAPGAG-------------------MC----------------------------- 1046

  Fly  1544 KSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDV 1608
                               :|.|..|:|||:|.||||:||:.:.|..|:|||.|||..::..|:|
Mosquito  1047 -------------------MDSFRLLSVLGRGHFGKVILAQYKHTGEYFAIKALKKGDIIARDEV 1092

  Fly  1609 DSTLIERKVLALGT--KHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYG 1671
            :|.|.|:::..:..  :||:|.:||..|||:.|:.|||||..|||||.|| .:..|||.||.||.
Mosquito  1093 ESLLSEKRIFEVANTMRHPFLVNLFSCFQTDQHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYA 1156

  Fly  1672 AEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEI 1736
            |.::.||::||:..||||||||||:|||.||:|:|||||:||..:.......:|||||:::|||:
Mosquito  1157 ACVVLGLQYLHESKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEV 1221

  Fly  1737 IKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLE 1801
            :....|.:.||||..|||::|||:|:|||.|.||:|:|.||.|:...:|.::|.||..|::.||.
Mosquito  1222 LTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAIMRRLLR 1286

  Fly  1802 KDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLT 1866
            |:..:|:||....|.|:....|||.|.|..|..::::|||.|.|:...|...||..||.|:..||
Mosquito  1287 KNPDRRLGSSERDAEDVKRQAFFRNIVWDDLLLKKVKPPFVPTVRSAEDVSNFDEEFTSEKPALT 1351

  Fly  1867 -PIDKEILASMDQKQFHGFTY 1886
             |.|..:|..::|..|..|||
Mosquito  1352 PPKDPRVLTEVEQTYFKDFTY 1372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	Herpes_BLLF1	<802..1131	CDD:282904	72/379 (19%)
		STKc_nPKC_theta_like	1570..1889	CDD:270744	150/320 (47%)
Pkn	XP_061507643.1	None