Protein Alignment Uch-L5R and Bap1

DIOPT Version :10

• Sequence 1: NP_572781.1
• Gene: Uch-L5R / 32173
• FlyBaseID: FBgn0030370
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_001100762.1
• Gene: Bap1 / 306257
• RGDID: 1311938
• Length: 740
• Species: Rattus norvegicus
• Alignment Length: 286
• Identity: 97/286 - (33%)
• Similarity: 155/286 - (54%)
• Gaps: 46/286 - (16%)

  Fly    25 WCLIESDPGVFTEMISGF-------------GCTGAEVEEIWSIKADAFRHLEPIHGLIFLFKWL 76
            |..:|||||:||.::..|             |..|.:||||:.:::   :...|::|.||||||:
  Rat     5 WLELESDPGLFTLLVEDFGKNPFTPDRRALAGVKGVQVEEIYDLQS---KCQGPVYGFIFLFKWI 66

  Fly    77 DDKPAGRVVTDRSD------------IFFARQVIPNACATQALLCLLLNLQHEDIDLGQTLTDLR 129
            :::.:.|.|:...|            :|||.|:|||:|||.|||.:|||.  .::|||.||:.::
  Rat    67 EERRSRRKVSTLVDDTSVIDDDIVNSMFFAHQLIPNSCATHALLSVLLNC--SNVDLGPTLSRMK 129

  Fly   130 NLCQDLDPECRGHRLANEEKIRKVHNSFARPELFVVEESTDFIED----DCYHFVGFMPIKGKLF 190
            :..:...||.:|:.:.|..::.|.|||.||||...:.|..:.:..    :.:|||.::||.|:||
  Rat   130 DFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLF 194

  Fly   191 ELDGMHEGPIELADIDQQQNWLDVVRPIIEARMERYSVGE----IHFNLMALVSDRQRCYERKIQ 251
            ||||:...||:.....:.:.|.|..|.:|..|:...:.||    |.|||||:|.||:..||.::.
  Rat   195 ELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRVKYEARLH 259

  Fly   252 MLVNLPSQLSHADRQAEIANLRSHVR 277
            :|        ..:||..:..|:..:|
  Rat   260 VL--------KGNRQTVLEALQQLIR 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uch-L5R	NP_572781.1	Peptidase_C12_UCH37_BAP1	25..238	CDD:187738	86/245 (35%)
		UCH_C	269..314	CDD:465622	2/9 (22%)
Bap1	NP_001100762.1	Peptidase_C12_UCH37_BAP1	5..246	CDD:187738	86/245 (35%)
		Arg-finger motif. /evidence=ECO:0000250|UniProtKB:Q92560	69..73		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..364
		HBM-like motif. /evidence=ECO:0000250|UniProtKB:Q92560	376..379
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..448
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..535
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	586..635
		Interaction with BRCA1. /evidence=ECO:0000250|UniProtKB:Q92560	607..732
		Interaction with YY1. /evidence=ECO:0000250|UniProtKB:Q92560	653..697
		UCH_C	654..699	CDD:465622
		Classical bipartite Nuclear localization signal (NLS). /evidence=ECO:0000250|UniProtKB:Q92560	710..733
		Interaction with nucleosomal DNA forming a DNA clamp with ASXL1. /evidence=ECO:0000250|UniProtKB:Q92560	710..712
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	715..740
		Positively charged C-terminal extension (CTE). /evidence=ECO:0000250|UniProtKB:Q92560	724..740
		Non-classical PY-nuclear localization signal (PY-NLS). /evidence=ECO:0000250|UniProtKB:Q92560	728..735
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q92560	728..733