DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uch-L5R and ubh-4

DIOPT Version :9

Sequence 1:	NP_572781.1	Gene:	Uch-L5R / 32173	FlyBaseID:	FBgn0030370	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001379065.1	Gene:	ubh-4 / 174289	WormBaseID:	WBGene00006724	Length:	321	Species:	Caenorhabditis elegans

Alignment Length:	313	Identity:	146/313 - (46%)
Similarity:	208/313 - (66%)	Gaps:	11/313 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TAANNWCLIESDPGVFTEMISGFGCTGAEVEEIWSIKADAFRHLEPIHGLIFLFKWLDDKPAGRV 84
            |.|.:||||||||||||||:.|||..|.:|||::|:..|. ....|.:||||||||........:
Worm     2 TDAGSWCLIESDPGVFTEMLRGFGVDGLQVEELYSLDDDK-AMTRPTYGLIFLFKWRQGDETTGI 65

  Fly    85 VTDRSDIFFARQVIPNACATQALLCLLLNLQHEDIDLGQTLTDLRNLCQDLDPECRGHRLANEEK 149
            .:|:.:||||.|.|.||||||||:.||:|::..|:.||..|...:....||||..|||.|:|.|:
Worm    66 PSDKQNIFFAHQTIQNACATQALINLLMNVEDTDVKLGNILNQYKEFAIDLDPNTRGHCLSNSEE 130

  Fly   150 IRKVHNSFARPELFVVEESTDFIEDDCYHFVGFMPIKGKLFELDGMHEGPIELADIDQQQNWLDV 214
            ||.|||||:|..||.::......||: ||||.::||..|::||||:.|.|:|:|:..::|:|::.
Worm   131 IRTVHNSFSRQTLFELDIKGGESEDN-YHFVTYVPIGNKVYELDGLRELPLEVAEFQKEQDWIEA 194

  Fly   215 VRPIIEARMERYSVGEIHFNLMALVSDRQRCYERKIQ-MLVNLPSQLSHADRQAEIANLRSHVRH 278
            ::|:|:.||::||.|||.|||||||.:|    ::|:| |:.||.....:.:.:.:||:|...:..
Worm   195 IKPVIQQRMQKYSEGEITFNLMALVPNR----KQKLQEMMENLIQANENNELEEQIADLNKAIAD 255

  Fly   279 EKEKKRRYRKENIRRRHNYLPFIVELLKQLGETGQLMAICDK----AKDRSYL 327
            |..|...|||||.||||||.||::||:|.|.:.|:|:.:.|.    ||::|.|
Worm   256 EDYKMEMYRKENNRRRHNYTPFVIELMKILAKEGKLVGLVDNAYQAAKEKSKL 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uch-L5R	NP_572781.1	Peptidase_C12_UCH37_BAP1	25..238	CDD:187738	106/212 (50%)
ubh-4	NP_001379065.1	Peptidase_C12_UCH37_BAP1	7..218	CDD:187738	106/212 (50%)
ubh-4	NP_001379065.1	UCH_C	246..291	CDD:407868	23/44 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167045
Domainoid	1	1.000	241	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E1_KOG2778
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	322	1.000	Inparanoid score	I1477
Isobase	1	0.950	-	0	Normalized mean entropy	S1802
OMA	1	1.010	-	-		QHG53985
OrthoDB	1	1.010	-	-		D1363547at2759
OrthoFinder	1	1.000	-	-		FOG0001783
OrthoInspector	1	1.000	-	-		otm14336
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1589
SonicParanoid	1	1.000	-	-		X1137
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.850