Protein Alignment Usp7 and usp34

DIOPT Version :10

• Sequence 1: NP_572779.2
• Gene: Usp7 / 32169
• FlyBaseID: FBgn0030366
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: XP_009292973.3
• Gene: usp34 / 562779
• ZFINID: ZDB-GENE-100210-6
• Length: 3624
• Species: Danio rerio
• Alignment Length: 1268
• Identity: 279/1268 - (22%)
• Similarity: 441/1268 - (34%)
• Gaps: 403/1268 - (31%)

  Fly    72 LLADSSSTSF-GDGEA---MGIDDESKEDQFRSETTFSF-----TVENV-VQLKSQR--LSPPVY 124
            |||.|:...| .|.:|   :.::|..:|..|||.....|     .::|: |:..||.  |.....
Zfish  1754 LLAASTLLKFLPDAQALKPLRVEDFEEEAMFRSGCKEYFWLLCKLIDNIHVKDASQTTLLDLDAL 1818

  Fly   125 VRMLP----WRIMVIPNDRALGFFLQCNGENDSPTWSCNAIAELRLKC----HKP------DAQP 175
            .|.|.    .|.::...|.|:        |:|..|      ..|||..    |||      :.|.
Zfish  1819 ARHLADCIRSREILDQQDGAI--------EDDGLT------GLLRLATSVLKHKPPFKFSREGQE 1869

  Fly   176 FTRARIKHLFY---SKENDY-----------GYSNFITWQELKDSEKSY--VHNNSITLEVHVVA 224
            |.|.....||.   .|:...           .|...:  :.:|.|.::|  :||  ..:..|:.|
Zfish  1870 FLRDTYDLLFLLPSLKDRQQPKCKSPAARAAAYDLLV--EVVKGSVENYRLLHN--WVMSQHMQA 1930

  Fly   225 D-APHGVLWDSKKHTG------YVGLKNQGATCYMNSLLQTLYFTNSLRLSVYRIPTEADDSSKS 282
            . ||:  .||...|..      :|||.|.|||||:.|.:|.||.....|.:|:......|...|:
Zfish  1931 SHAPY--KWDYWPHDDVRAECRFVGLTNLGATCYLASTIQQLYMIPEARQAVFTAKYSEDIKHKT 1993

  Fly   283 VGLSLQRVFHELQFGDRPVGTKK---LTKSFGWETLDSFMQHDVQEFLRVLLDKLESKMKGTILE 344
            ..|.||::|..|...:|.....:   .|.:...:.|::..|.|:.||...|:.|:|...:.  |:
Zfish  1994 TLLELQKMFTYLMESERKAYNPRPFCKTYTMDKQPLNTGEQKDMTEFFTDLITKIEEMSQD--LK 2056

  Fly   345 GTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKNIYESFQDYVAPETLEGDNKYDAG 409
            .|:..||.|.:::.:...:.|:.|...|.||.::..:.|.||||||..:....:||||||.|...
Zfish  2057 NTVKTLFGGVITNNVVSLDCDHVSQTAEEFYTVRCQVADMKNIYESLDEVTIKDTLEGDNMYTCS 2121

  Fly   410 VHGLQ-EASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRY---------- 463
            ..|.: .|.|...|...|.:|..:.||:.::.||....|.|..|.|...:::..|
Zfish  2122 QCGKKVRAEKRACFKKLPRILSFNTMRYTFNMVTMMKEKVNTHFSFPLRLDMTPYTEDFLMAKGD 2186

  Fly   464 ------------LAESENTLADYVLHAVLVHSGDNHGGHYVVF----INPKA--DGRWFKFDD-- 508
                        :|||    .:|.|..|.||:|...||||..|    |||.|  :.:|:.|:|
Zfish  2187 RKEGFRDDSDAKVAES----YEYDLIGVTVHTGTADGGHYYSFIRDIINPHAYRNNKWYLFNDAE 2247

  Fly   509 -------DVVSSCRKQEAIEQNYGGMDD---EISFHAKCSNAYMLVYIRQSELDRVLGDITESEI 563
                   .:.|.|...|...:.|..:.|   :.||. |..:||||.| ::.|::...|.....:|
Zfish  2248 VKPFDSAQLASECFGGEMTTKTYDSVTDKFMDFSFE-KTHSAYMLFY-KRVEVEEENGKDFNFDI 2310

  Fly   564 SSDLVERLDLEKRIEMARRKERGEANTYVSVHVILEENFEEQHKRRLFDLEKVHPRVFRIKQNQT 628
            |.||:|                          .|..:|.:....:.:|:    |..
Zfish  2311 SPDLLE--------------------------WIWHDNMQFLQDKNIFE----HTY--------- 2336

  Fly   629 VDELVDLFVRGFGVSRQRMRMWNLCTA-------------QTQKFSHFDFVAEGSRTIEQISTSQ 680
                       ||.      ||.||::             .|.|.| ..||.|     ..|.:.:
Zfish  2337 -----------FGF------MWQLCSSIPSTLPDPKSVSLMTAKLS-TSFVLE-----TFIHSKE 2378

  Fly   681 KPWVI-WLQLA-----------------------W------------------------------ 691
            ||.:: |::|.                       |
Zfish  2379 KPTMLQWIELLTKQFNNSQAACEWFLDQMADDNWWPMQILIKCPNQIVRQMFQRLCIHVIQRLRP 2443

  Fly   692 ---------------TDVPGPLPPFNPKTESLLFLKYYDPRNKRLNYIGCTQQPHTRRLIDLVPD 741
                           .|:.||:.....::....|:|      ..|:.:....:||::.|.:....
Zfish  2444 VHAHLYLQPGMEDGSDDMDGPVEDIGSRSCVTRFVK------TLLSIMEHGVKPHSKHLTEYFAF 2502

  Fly   742 VN--SKLGFE--------------------------PDTELTIYDEYA----DKKLVNLNE---- 770
            :.  :|:|.|                          |..|:...:|..    ::.:::|.|
Zfish  2503 LYEFAKMGEEESQFLLSLQAISIMVHFYMGTKGPENPQVEVLSEEEEGEEDEEEDILSLAEEKYR 2567

  Fly   771 --PIES-----ALFIPQDHLQGHILIFERENVDAKLDLPTV----GDYFLDLVYRIEIIFSDKCN 824
              .:|.     :|.:.|...:.|:.:       ::.|:..:    |..||....|..|.....||
Zfish  2568 PAALEKMIALISLLVEQSRSERHLTL-------SQSDMAALTGGKGFPFLFQHIRDSINIRQTCN 2625

  Fly   825 PNEPDFTLELSNRYNYDQLANAVAERLNTDPQKL------QFFMCINNYKETAGN--AVPYTFKG 881
               ..|:|   .||| ::||..:...|.|...||      .||..:....|.|..  .:|
Zfish  2626 ---LIFSL---CRYN-NRLAEHIVSMLFTSIAKLTPEAANPFFKLLTMLMEFAAGPPGMP----- 2678

  Fly   882 TIKDLVSYTKQSSTKRIFY---QRLS-LSIHELDNKKQFKCVWVSSDLKDEKELVL----YPNKN 938
               ...||..|...:.|.|   |.|. |::....||....  ||..::::..|..|    ||...
Zfish  2679 ---SFASYILQRIWEVIEYNPSQCLDWLAVQTPRNKLAHS--WVLQNMENWVERFLLAHNYPRVR 2738

  Fly   939 DTVKGLLEEAAKKISFAENSRRKLRLLKISNHKIVAVCKDDIPL--DTLLKSNESITTAQGAQKT 1001
            .:...||.......||.: ..|..|.|.|...        |:||  ||.:..::......|....
Zfish  2739 TSAAYLLVSLIPSNSFRQ-MFRSTRSLHIPTR--------DLPLSPDTTVVLHQVYNLLLGLLGR 2794

  Fly  1002 FRI-EEVPAEDMQ-------------LAENEFLIPVAHFSKELYNSFGIPFLTKARQGEPYGALK 1052
            .:: .:||.....             :::.|.|:..::| .:|:|.|      :.:..||..|..
Zfish  2795 AKLYVDVPVHGTTKLVQYFSFMTYCLISKTEKLMFSSYF-MDLWNLF------QPKLSEPAIATN 2852

  Fly  1053 QRIQRRLNVQDKEWENYKFCVISMGHNADVNDN 1085
            ...|..|:.    |  |..||       |.::|
Zfish  2853 HNKQALLSF----W--YNVCV-------DCSEN 2872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	Peptidase_C19	101..1119	CDD:470612	267/1235 (22%)
usp34	XP_009292973.3	peptidase_C19C	1950..2297	CDD:239124	105/354 (30%)
		DUF3517	2416..2749	CDD:463438	63/362 (17%)