DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tango4 and prp5

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_595604.1	Gene:	prp5 / 3361260	PomBaseID:	SPBP22H7.07	Length:	473	Species:	Schizosaccharomyces pombe

Alignment Length:	475	Identity:	248/475 - (52%)
Similarity:	327/475 - (68%)	Gaps:	20/475 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VHTLIFRSLKRTHDLFVSNQGNLPEIDERL-EKLRRSIKAKDGYGLVLDKVAKIGEARKASGAQ- 73
            |.:|...||:.:..||.:..|::...|:.: :.|:|:.|....||.||.  ..:|:.:.....:
pombe    13 VLSLTTNSLRTSKTLFGAEFGSVTSFDDTVAQNLKRTYKEHLEYGSVLG--GTVGKRKNRHYEED 75

  Fly    74 TPGDKTLAITDGSATDAASGAGSLVKYNAGARPAEKTAPLVTGTHTSLVRASLANSNADMSANGA 138
            |.|...|.:...|...::.   .:.|:   :.|.:|.|..|:       ..||........|...
pombe    76 TIGSNALTVRADSENPSSQ---VITKF---SDPNKKIAGQVS-------MQSLEKIKGVPEAAHR 127

  Fly   139 IA--SHLQLIPKKAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPGNEWFATGAGDRVIKIWDL 201
            ||  |...|:.:......:|:|||||.|.||||||||||||:.|||||:||.||||||.||||||
pombe   128 IAGESQASLVKRTLAEQIRPEWHAPWTLMRVISGHLGWVRCVDVEPGNQWFCTGAGDRTIKIWDL 192

  Fly   202 ASGKLKLSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSLALHP 266
            |||.|||:||||::||||:|||.:||||||||||:.|||||||.||||||||||||.||:|.|||
pombe   193 ASGVLKLTLTGHIATVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYALKLHP 257

  Fly   267 TIDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGK 331
            |:|||.|:|||:.||:|||||:.|||.|:||.:||||:..|..:||::|||.|||:|||||||||
pombe   258 TLDVLVTAGRDAVARVWDMRTRQNVHVLSGHKSTVASLAVQEFDPQVVTGSMDSTIRLWDLAAGK 322

  Fly   332 SVCTLTNHKKSVRSIVLHPSLYMFASASPDNIKQWRCPEGKFVQNISGHTSIVNCMAANSEGVLV 396
            ::.|||:|||:||::.|||..:.|||.|.||||.|:.|||.|:.|..||.:|||.::.||:.|:.
pombe   323 TLTTLTHHKKTVRALSLHPDEFTFASGSSDNIKHWKFPEGAFMGNFEGHNAIVNTLSINSDNVMF 387

  Fly   397 SGGDNGTMFFWDWRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSGSRLITAEADKTIKVYKEDD 461
            ||.|||:|.||||::|:.:|..|:.|||||:||||||||..||::|.||||.||||::|:||:.|
pombe   388 SGADNGSMCFWDWKSGHKYQELQSVVQPGSLDSEAGIFASSFDKTGLRLITCEADKSVKIYKQVD 452

  Fly   462 EASEESHP-INWRPDLLKRR 480
            .|:.|:|| :.|.|..|:||
pombe   453 NATPETHPNLPWTPSNLRRR 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	200/296 (68%)
		WD40	164..458	CDD:238121	198/293 (68%)
		WD40 repeat	177..212	CDD:293791	27/34 (79%)
		WD40 repeat	218..254	CDD:293791	29/35 (83%)
		WD40 repeat	259..295	CDD:293791	24/35 (69%)
		WD40 repeat	302..337	CDD:293791	21/34 (62%)
		WD40 repeat	343..378	CDD:293791	19/34 (56%)
		WD40 repeat	386..426	CDD:293791	19/39 (49%)
		WD40 repeat	433..457	CDD:293791	15/23 (65%)
prp5	NP_595604.1	WD40	<143..402	CDD:225201	176/258 (68%)
		WD40	155..449	CDD:238121	198/293 (68%)
		WD40 repeat	168..203	CDD:293791	27/34 (79%)
		WD40 repeat	209..245	CDD:293791	29/35 (83%)
		WD40 repeat	250..286	CDD:293791	24/35 (69%)
		WD40 repeat	293..328	CDD:293791	21/34 (62%)
		WD40 repeat	334..369	CDD:293791	19/34 (56%)
		WD40 repeat	375..414	CDD:293791	18/38 (47%)
		WD40 repeat	424..448	CDD:293791	15/23 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	91	1.000	Domainoid score	I2036
eggNOG	1	0.900	-	-		E1_KOG0285
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2004
Inparanoid	1	1.050	489	1.000	Inparanoid score	I256
OMA	1	1.010	-	-		QHG53955
OrthoFinder	1	1.000	-	-		FOG0004264
OrthoInspector	1	1.000	-	-		oto101044
orthoMCL	1	0.900	-	-		OOG6_101928
Panther	1	1.100	-	-	LDO	PTHR19923
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R995
SonicParanoid	1	1.000	-	-		X3002
TreeFam	1	0.960	-	-
	14	13.860