Protein Alignment HOXB5 and Ubx

DIOPT Version :10

• Sequence 1: NP_002138.1
• Gene: HOXB5 / 3215
• HGNCID: 5116
• Length: 269
• Species: Homo sapiens
• Sequence 2: NP_536752.1
• Gene: Ubx / 42034
• FlyBaseID: FBgn0003944
• Length: 389
• Species: Drosophila melanogaster
• Alignment Length: 325
• Identity: 105/325 - (32%)
• Similarity: 135/325 - (41%)
• Gaps: 100/325 - (30%)

Human     6 VNSFSGRYPNGPDYQLLNYGSGSSLSGSYRDPAAMHTGSYGYNYNGMDLSVNRSSASSSHFGAVG 70
            ||.:...:..|..    |.|.|....|.  ...|..||..| |.||       .:|::::    |
  Fly    97 VNGYKDIWNTGGS----NGGGGGGGGGG--GGGAGGTGGAG-NANG-------GNAANAN----G 143

Human    71 ESSRAFPAPAQEPRFRQAASSCS--------LSSPESLPCTN-GDSHGAKPSASSPSDQATSASS 126
            :::.|...|.:       .|:|:        |.:....|.:: |.|.|...|.|..:..|....|
  Fly   144 QNNPAGGMPVR-------PSACTPDSRVGGYLDTSGGSPVSHRGGSAGGNVSVSGGNGNAGGVQS 201

Human   127 -----------SANFTEIDEASASSEPEEAASQLSSPSLARAQPEPMATSTAAPEGQTPQIFPWM 180
                       :||.| |..|:|.:   .|||.|...|.....|. ||.:...||..|
  Fly   202 GVGVAGAGTAWNANCT-ISGAAAQT---AAASSLHQASNHTFYPW-MAIAGECPEDPT------- 254

Human   181 RKLHISHDMT--------------------------GPDG--KRARTAYTRYQTLELEKEFHFNR 217
             |..|..|:|                          |.:|  :|.|..||||||||||||||.|.
  Fly   255 -KSKIRSDLTQYGGISTDMGKRYSESLAGSLLPDWLGTNGLRRRGRQTYTRYQTLELEKEFHTNH 318

Human   218 YLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKD--------------NKLKSMSLATAGSAFQ 268
            |||||||||:||||||:||||||||||||||.||:              ...|:.:.|.|.:|.|
  Fly   319 YLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEIQAIKELNEQEKQAQAQKAAAAAAAAAAVQ 383

Human   269  268
              Fly   384  383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	29/123 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..173		28/115 (24%)
		Antp-type hexapeptide	176..181		0/4 (0%)
		Homeodomain	195..251	CDD:459649	46/55 (84%)
Ubx	NP_536752.1	Homeodomain	296..352	CDD:459649	46/55 (84%)