DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXB5 and pb

DIOPT Version :9

Sequence 1:	NP_002138.1	Gene:	HOXB5 / 3215	HGNCID:	5116	Length:	269	Species:	Homo sapiens
Sequence 2:	NP_476669.3	Gene:	pb / 40826	FlyBaseID:	FBgn0051481	Length:	782	Species:	Drosophila melanogaster

Alignment Length:	193	Identity:	65/193 - (33%)
Similarity:	88/193 - (45%)	Gaps:	58/193 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   116 SPSDQATSASSSANFTEIDEASASSEPE--EAASQLS--SPSLARAQPEPMATSTAA-------- 168
            :|:....||.::...|..:....:|:|.  |..:.||  ||.:.    .|:.:....
  Fly    79 TPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPESPKIG----TPVGSGAIGGVGVNVNV 139

Human   169 --------PEGQTPQI---------FPWMRKLHISHDMTG-------------PDG---KRARTA 200
                    |.|..||.         :|||::...|...:.             |:.   :|.|||
  Fly   140 NVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKKTSRKSSNNNNQGDNSITEFVPENGLPRRLRTA 204

Human   201 YTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKK---------DNK 254
            ||..|.||||||||||:||.|.||||||.:|.|:|||:|:||||||||.|:         |||
  Fly   205 YTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKTDDEDNK 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	13/74 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..173		14/76 (18%)
		Antp-type hexapeptide	176..181		2/13 (15%)
		Homeobox	198..251	CDD:395001	39/52 (75%)
pb	NP_476669.3	COG5576	168..274	CDD:227863	47/100 (47%)
pb	NP_476669.3	Homeobox	202..254	CDD:278475	39/51 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810