DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP7 and PAA2

DIOPT Version :9

Sequence 1:	NP_001259466.1	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001031920.1	Gene:	PAA2 / 832253	AraportID:	AT5G21930	Length:	883	Species:	Arabidopsis thaliana

Alignment Length:	1026	Identity:	306/1026 - (29%)
Similarity:	489/1026 - (47%)	Gaps:	211/1026 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 PTPPPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILVALLAAKA 248
            |.|||       |::.|...:.|:.:||..:|.       :.|.:||.:.:.|.|..|.:    :
plant     9 PLPPP-------SSLHIRPSKFLVNRCFPRLRR-------SRIRRHCSRPFFLVSNSVEI----S 55

  Fly   249 EVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHVLKIRGVT 313
            ...|.:...:.|:: ||||.        |.|      :.|::.||.|..||.:::|.::....|.
plant    56 TQSFESTESSIESV-KSITS--------DTP------ILLDVSGMMCGGCVARVKSVLMSDDRVA 105

  Fly   314 TASVTLLTKRGKFRY-----ITEETGPRSICEAIEALGFEAKLMTGRDKMAHNYLEHKEEIRKWR 373
            :|.|.:||:....::     :|.:|. .|:.:.:...|||||.......:|.|       ::||:
plant   106 SAVVNMLTETAAVKFKPEVEVTADTA-ESLAKRLTESGFEAKRRVSGMGVAEN-------VKKWK 162

  Fly   374 NAFLVS----LIFGGPCMVAMIYFMLEMSDKGHANMCCLVPGLSMEN---------------LVM 419
            .  :||    |:......||..:.::.:....|.:......|:.:.:               |.:
plant   163 E--MVSKKEDLLVKSRNRVAFAWTLVALCCGSHTSHILHSLGIHIAHGGIWDLLHNSYVKGGLAV 225

  Fly   420 FLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFF 484
            ..|..|     |........:|....:.||:.|:.:.:..::..|: :.:....||.::|   ||
plant   226 GALLGP-----GRELLFDGIKAFGKRSPNMNSLVGLGSMAAFSISL-ISLVNPELEWDAS---FF 281

  Fly   485 DTPPMLLIFISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKV---------I 540
            |.|.|||.|:.|||.||..||.:.|..:::||||.:..:.||..|.|.:...:.|         :
plant   282 DEPVMLLGFVLLGRSLEERAKLQASTDMNELLSLISTQSRLVITSSDNNTPVDSVLSSDSICINV 346

  Fly   541 SVDYVQRGDILKVIPGAKVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLV 605
            |||.::.||.|.|:||...||||.||.|.|..|||::||||:||.|.:|..|..|:||.:|.|.:
plant   347 SVDDIRVGDSLLVLPGETFPVDGSVLAGRSVVDESMLTGESLPVFKEEGCSVSAGTINWDGPLRI 411

  Fly   606 EATHTGENTTLAQIVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLV 670
            :|:.||.|:|:::|||:||:||.:.||:|:|||.|||.||..::.:|::|...|..:|   .::.
plant   412 KASSTGSNSTISKIVRMVEDAQGNAAPVQRLADAIAGPFVYTIMSLSAMTFAFWYYVG---SHIF 473

  Fly   671 P-VAMEHKMHMDQNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATAL 734
            | |.:......|.:.:.:|  .|.|:.||.::||||||||||||:::.|..||..|.|::|...|
plant   474 PDVLLNDIAGPDGDALALS--LKLAVDVLVVSCPCALGLATPTAILIGTSLGAKRGYLIRGGDVL 536

  Fly   735 ENAHKVKTVVFDKTGTITHGTPMTSKVTLFVTAQVCSLA----RALTIVGAAEQNSEHPIASAIV 795
            |....:..|..|||||:|.|.|        |.:.|.||.    ..|.:..|.|:.:.||||.|||
plant   537 ERLASIDCVALDKTGTLTEGRP--------VVSGVASLGYEEQEVLKMAAAVEKTATHPIAKAIV 593

  Fly   796 HFAKDMLNVGATPQAGSFGKSSHFQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLHRTHPQG 860
            :.| :.||:......|...:       ||.|          ||.:
plant   594 NEA-ESLNLKTPETRGQLTE-------PGFG----------TLAE-------------------- 620

  Fly   861 SVPVDNGASIEHLLPQRSVRKSMELNNQQLLSDLVLEPEEELLTDQKIIDSPEILVLIGNREW-- 923
                                                            ||..  .|.:|:.||
plant   621 ------------------------------------------------IDGR--FVAVGSLEWVS 635

  Fly   924 ---MERNAIEVPLEISDCMTHE-------ERKGHTAVLCALNGQ-LVCMFAVSDMVKPEAHLAVY 977
               :::|.....:::...:.|:       .|...|.|.....|: ::...|:||.::.:|...|.
plant   636 DRFLKKNDSSDMVKLESLLDHKLSNTSSTSRYSKTVVYVGREGEGIIGAIAISDCLRQDAEFTVA 700

  Fly   978 TLKRMGIDVVLLTGDNKNTAASIAREVGIR---TVYAEVLPSHKVAKIQRIQANGIRVAMVGDGV 1039
            .|:..||..|||:||.:...|::|:.|||:   |.|: :.|..|...|..:|::|.||||||||:
plant   701 RLQEKGIKTVLLSGDREGAVATVAKNVGIKSESTNYS-LSPEKKFEFISNLQSSGHRVAMVGDGI 764

  Fly  1040 NDSPALAQADVGIT--IAAGTDVAAEASDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYN 1102
            ||:|:||||||||.  |.|..:.|:.|:.::|:||.|..||..|.|::.|:.::..|..:|..||
plant   765 NDAPSLAQADVGIALKIEAQENAASNAASVILVRNKLSHVVDALSLAQATMSKVYQNLAWAIAYN 829

  Fly  1103 LLGIPLASGLFAP-YGFTLLPWMASVAMAASSVSVVCSSLLLKMYRKPTAK 1152
            ::.||:|:|:..| |.|.:.|.::...||.||:.||.:||||::::..|:|
plant   830 VISIPIAAGVLLPQYDFAMTPSLSGGLMALSSIFVVSNSLLLQLHKSETSK 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_001259466.1	HMA	16..78	CDD:238219
		HMA	97..159	CDD:238219
		HMA	214..274	CDD:238219	13/59 (22%)
		ZntA	285..1131	CDD:225127	271/902 (30%)
		HMA	287..350	CDD:238219	18/67 (27%)
		E1-E2_ATPase	489..735	CDD:278548	108/255 (42%)
		COG4087	<984..1085	CDD:226572	49/105 (47%)
PAA2	NP_001031920.1	ZntA	80..871	CDD:225127	278/911 (31%)
		HMA	80..146	CDD:238219	18/66 (27%)
		E1-E2_ATPase	285..537	CDD:278548	108/256 (42%)
		COG4087	681..799	CDD:226572	49/118 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2217
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649559at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780