Protein Alignment ATP7 and SPoCk

DIOPT Version :10

• Sequence 1: NP_572756.3
• Gene: ATP7 / 32142
• FlyBaseID: FBgn0030343
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Alignment Length: 1136
• Identity: 222/1136 - (19%)
• Similarity: 397/1136 - (34%)
• Gaps: 394/1136 - (34%)

  Fly   169 SPSPAPASSPKKRATPTPPPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKI 233
            |.:|.|.:| |:|.:|..|       ||.|.              |...|.:|   .:.....||
  Fly     2 SKTPKPLTS-KRRTSPASP-------GSTVL--------------IESPTTSS---GVRNRRSKI 41

  Fly   234 YGLDSILVALLAAKAEVKFN-ANVVTAENIAKSITELGFPTELID-----EPDNGEAEVELEIMG 292
            .|:||            |.| ...::....::::.:...|.::.|     |||...
  Fly    42 KGVDS------------KPNPQRTISHVKDSRAVPQNVKPGKVADMKDCKEPDEDN--------- 85

  Fly   293 MTCASCVNKIESHVLKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTG--- 354
                  |::...:::: .|:|.....||:        |.|:...|..|....|  :..:.||
  Fly    86 ------VDQQNGNIIQ-TGLTLTPEMLLS--------TSESSTHSASEVAGRL--QVDVRTGLKW 133

  Fly   355 -----RDK-MAHNYL-------EHKEEIRKWRNAFLVSLIFGGPCMVAMIYFMLEMSDKGHANMC 406
                 |.| :.||.|       ..|:.|.::||..::.|:  |..:|::|  |.:..|
  Fly   134 TEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLL--GSALVSVI--MKQFDD------- 187

  Fly   407 CLVPGLSMENLVMFLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAA 471
                  ::...:..|:...|.|       :|.||:.|    :::.|..:|
  Fly   188 ------AVSITIAILIVVTVAF-------IQEYRSEK----SLEELKKLV--------------- 220

  Fly   472 VLLEQNSSPLTFFDTPPMLLIFISLGRWLEH-IAKGKTSEALSKLLSLKAADALLVEISPDFDII 535
                           ||..           | :.:|:....|::            |:.|
  Fly   221 ---------------PPEC-----------HCLREGRLDTFLAR------------ELVP----- 242

  Fly   536 SEKVISVDYVQRGDILKVIPGAKVPVDGKVLYG-HSSCDESLITGESMPVAK------------- 586
                        |||:.:..|.:||.|.::... ..|.|||..|||:.|..|
  Fly   243 ------------GDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVKD 295

  Fly   587 ---RKGSVVIGGSI---NQNGVLLVEATHTGENTTLAQIVRLVEEAQTSKAPIQQLADRIAGYFV 645
               .|....:|..:   |..|:::    .|||.:...::.::::..:..|.|:|:..| |.|..:
  Fly   296 HSNMKNIAFMGTLVRCGNGKGIVV----STGERSEFGEVFKMMQAEEAPKTPLQKSMD-ILGAQL 355

  Fly   646 PF--VVVVSSITLIAWIIIGFSNPNLVPVAMEHKMHMDQNTIIVSYAFKCALSVLAIACPCALGL 708
            .|  .:::..|.|:.|:   ...|                   :|..|..::|:...|.|..|
  Fly   356 SFYSFLIIGVIMLLGWL---QGKP-------------------LSEMFNISVSLAVAAIPEGL-- 396

  Fly   709 ATPTAVMVATGTG----AINGVLVKGATALENAHKVKTVVFDKTGTITHGTPMTSKVTLFVTAQV 769
              |..|.|....|    |....:||....:|....|..:..|||||:|. ..||:  |:.:|:.
  Fly   397 --PIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTK-NEMTA--TIIITSD- 455

  Fly   770 CSLARALTIVGAAEQNSEHPIASAIVHFAK----DMLNVGAT-----PQAGS-FGKSSHFQAVPG 824
             .....:|..|..:|...|......|..||    ::|.:||.     .|.|: .|:.:....|..
  Fly   456 -GYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYIQNGTLLGQPTEGALVAV 519

  Fly   825 C---GIRVTVSNYEQTLRQACNAD-RIINYENLHR-THPQGSVPVDNGASIEHLLPQRSVRKSME 884
            .   |:..|..||.:......::: :::..:.:|: .:.:..:....|| :|.||||.:   ..:
  Fly   520 AMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNKEEIFFAKGA-LETLLPQCT---KYQ 580

  Fly   885 LNNQQLLSDLVLEPEEELLTDQKIIDSPEILVLIGNREWMERNAIEVPLEISDCMTHEERKGHTA 949
            ...|.:  .|..:.|.|.|.:...|....:.||          |:.....:.|           .
  Fly   581 FGTQTV--PLTKQNEAEFLAEAYEIGRKGLRVL----------ALAKGRSMQD-----------L 622

  Fly   950 VLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASI-------------- 1000
            :.|.|.|       ::|..:|....::..|.:.|:.|.::|||.:.||.:|
  Fly   623 IYCGLVG-------ITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAI 680

  Fly  1001 --------------------------------------------AREVGIRTVYAEVL------- 1014
                                                        |..:||.|::.:.|
  Fly   681 PAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQ 745

  Fly  1015 --------------------PSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAA-GT 1058
                                |.||:..::.:|.:|..|.|.||||||..||.:||:||.:.. ||
  Fly   746 MNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGT 810

  Fly  1059 DVAAEASDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPW 1123
            ||..||:|::|:.:|...::|.::..:.....||         |.:...|::.: |......|..
  Fly   811 DVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIR---------NFVRFQLSTSI-AALALIALAT 865

  Fly  1124 MASVAMAASSVSVVCSSLLLKMYRKPTAKTL 1154
            :..:|...:::.::..::::.   .|.|::|
  Fly   866 LMDIANPLNAMQILWINIIMD---GPPAQSL 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7	NP_572756.3	CopZ	11..76	CDD:442020
		HMA	97..159	CDD:238219
		chaper_CopZ_Eh	212..276	CDD:411374	11/64 (17%)
		HMA	287..350	CDD:238219	10/62 (16%)
		P-type_ATPase_Cu-like	376..1130	CDD:319783	172/881 (20%)
SPoCk	NP_001262220.1	P-type_ATPase_SPCA	139..1042	CDD:319779	184/936 (20%)