Protein Alignment Cyp28c1 and CYP2B6

DIOPT Version :10

• Sequence 1: NP_572752.1
• Gene: Cyp28c1 / 32138
• FlyBaseID: FBgn0030339
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_000758.1
• Gene: CYP2B6 / 1555
• HGNCID: 2615
• Length: 491
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 131/546 - (23%)
• Similarity: 211/546 - (38%)
• Gaps: 108/546 - (19%)

  Fly     4 SLLLGIATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHFTMDMRDI---YMHY 65
            |:||.:|.|.| :...||....:...|....||.|||.|:.         ..||.|.:   ::.:
Human     4 SVLLFLALLTG-LLLLLVQRHPNTHDRLPPGPRPLPLLGNL---------LQMDRRGLLKSFLRF 58

  Fly    66 RNTHSYV-GCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLVALNPF------ 123
            |..:..| ..:|...|.:::.....:.|..|.....|.......|||          ||
Human    59 REKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVD----------PFFRGYGV 113

  Fly   124 -VLEGEEWRHQRAVFSTLLTN---GRIRTTHAIMQRVCLDLCQFIAIKSAGGKDLDCIDLGLRFT 184
             ...|..|:..|....|.:.:   |:......|.:..   .|....::.:.|..:|...|....|
Human   114 IFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEA---QCLIEELRKSKGALMDPTFLFQSIT 175

  Fly   185 GESLFDCVLGIQARTFTDNPLPVVRQNHEMSAE--------NRGLAIAGAVHG-LFPNLPRWLRP 240
            ...:...|.|              ::.|....|        .:..::..:|.| ||.....:|
Human   176 ANIICSIVFG--------------KRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFL-- 224

  Fly   241 KVFPRSHDRFYG--QMISEALRLRRSKHQER------NDFIN-HLLEMQRE-----LDLSEEDMA 291
            |.||.:|.:.|.  |.|:..:.....||:|.      .|.|: :||.|::|     .:.|.:::.
Human   225 KYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLN 289

  Fly   292 SHAMTFMFDGLDTTSNSIAHCLLLLGRNPDCQRRLYEELQLVNPGGYLPDLDALIDLPYLSACFN 356
            .:.::..|.|.:|||.::.:..||:.:.|....|:|.|::.|......|:|.....:||..|...
Human   290 LNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIY 354

  Fly   357 ESLR---IYPAGGWASKTCTKEYELRGSHHSEPLKLRPGDHVMVPIY--ALHNDPDLYPEPDVFR 416
            |..|   :.|.|  .....|:....||       .:.|.|..:..|.  ||| ||..:.:||.|.
Human   355 EIQRFSDLLPMG--VPHIVTQHTSFRG-------YIIPKDTEVFLILSTALH-DPHYFEKPDAFN 409

  Fly   417 PERFLD--GGLKNCKQQGIFLGFGNGPRQCVGMRLGLAMAKAAL--AAIVQRFEVV--VSPRTLN 475
            |:.|||  |.||..:   .|:.|..|.|.|:|.  |:|.|:..|  ..|:|.|.:.  |:|..::
Human   410 PDHFLDANGALKKTE---AFIPFSLGKRICLGE--GIARAELFLFFTTILQNFSMASPVAPEDID 469

  Fly   476 GTELDPLIFVGVHK--GGIWLQFVPR 499
            .|..:    .||.|  ....::|:||
Human   470 LTPQE----CGVGKIPPTYQIRFLPR 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_572752.1	CYP6-like	67..493	CDD:410679	109/472 (23%)
CYP2B6	NP_000758.1	CYP2B	62..486	CDD:410765	109/471 (23%)