Protein Alignment Cyp28c1 and CYP3A7

DIOPT Version :10

• Sequence 1: NP_572752.1
• Gene: Cyp28c1 / 32138
• FlyBaseID: FBgn0030339
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 127/479 - (26%)
• Similarity: 219/479 - (45%)
• Gaps: 46/479 - (9%)

  Fly     5 LLLGIATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFG---SFPNMIWPRQHFTMDMRDIYMHYR 66
            |||.::.:|  :|.:.....|.:::.|:..|..||..|   ||....|     |.|| :.|..||
Human    13 LLLAVSLIL--LYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYW-----TFDM-ECYKKYR 69

  Fly    67 NTHSYVGCYLLRAPKLLVLEPRLVYEIYV-SAFSHFENNDASKMVDIAKDRLVALNPFVLEGEEW 130
            ...   |.|..:.|.|.:.:|.::..:.| ..:|.|.|......|...|:.:     .:.|.|||
Human    70 KVW---GIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAI-----SIAEDEEW 126

  Fly   131 RHQRAVFSTLLTNGRIRTTHAIMQRVCLDLCQFIAIKSAGGKDLDCIDLGLRFTGESLFDCVLGI 195
            :..|::.|...|:|:::....|:.:....|.:.:..::..||.:....:...::.:.:.....|:
Human   127 KRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGV 191

  Fly   196 QARTFTDNPLPVVRQNHEMSAENR----GLAIAGAVHGLFPNLP---RWLRPKVFPRSHDRFYGQ 253
            ...:..:...|.|....::...|.    .|:|.     :||.|.   ..|...||||....|..:
Human   192 SIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIK-----VFPFLTPILEALNITVFPRKVISFLTK 251

  Fly   254 MISEALRLRRSKHQE-RNDFINHLLEMQRELD------LSEEDMASHAMTFMFDGLDTTSNSIAH 311
            .:.:....|..:.|: |.||:..:::.|...|      ||:.::.:.::.|:|.|.:|||:.::.
Human   252 SVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSF 316

  Fly   312 CLLLLGRNPDCQRRLYEELQLVNPGGYLPDLDALIDLPYLSACFNESLRIYPAGGWASKTCTKEY 376
            .:..|..:||.|:::.:|:..|.|....|..|.::.|.||....||:||::|......:.|.|:.
Human   317 IIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDV 381

  Fly   377 ELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGIFLGFGNGP 441
            |:.|      :.:..|..||:|.|.||:||..:.||:.|.||||......|.... |:..||:||
Human   382 EING------MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPY-IYTPFGSGP 439

  Fly   442 RQCVGMRLGLAMAKAALAAIVQRF 465
            |.|:|||..|...|.||..::|.|
Human   440 RNCIGMRFALVNMKLALVRVLQNF 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_572752.1	CYP6-like	67..493	CDD:410679	107/414 (26%)
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	109/417 (26%)