Protein Alignment PhKgamma and Phkg2

DIOPT Version :10

• Sequence 1: NP_511129.3
• Gene: PhKgamma / 32120
• FlyBaseID: FBgn0011754
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_081164.2
• Gene: Phkg2 / 68961
• MGIID: 1916211
• Length: 406
• Species: Mus musculus
• Alignment Length: 540
• Identity: 216/540 - (40%)
• Similarity: 276/540 - (51%)
• Gaps: 169/540 - (31%)

  Fly     7 DDLLPDKDAAKGFYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHML 71
            :|.|||..|||.||.||:||:|:|||:||.||||:.:.||.|||.||:::.|...|.| ....:.
Mouse     8 EDELPDWAAAKEFYQKYDPKDIIGRGVSSVVRRCVHRATGDEFAVKIMEVSAERLSLE-QLEEVR 71

  Fly    72 EATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQ 136
            :|||:|:.|||||.|||:||.|.|.:||.:|:||||:|..|||||||||..|.||||:||:|||.
Mouse    72 DATRREMHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRS 136

  Fly   137 IFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKC 201
            :.|.|.::||.:||||||||||||||:|..::::||||:..|:.||||..|||||||||||.|||
Mouse   137 LLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEAGEKLRELCGTPGYLAPEILKC 201

  Fly   202 NMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKD 266
            :|.|..|||.:|||:||||||:||||.|.||||||:|::|||.||||:|.||||||.|.|...||
Mouse   202 SMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFTSPEWDDRSNTVKD 266

  Fly   267 LIRKCLVVDPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPIAPAQTNSRHLLQPEASSYRFGQLN 331
            ||.|.|.|||..|:|.::.|:||||.:
Mouse   267 LISKLLQVDPEARLTAEQALQHPFFER-------------------------------------- 293

  Fly   332 SSCAGAPNYLYCAPQSSYSSNRMRDGALDDAGASAASATCHVMSPSNASNSYATNTTANTSNSAL 396
              |.|:
Mouse   294 --CEGS----------------------------------------------------------- 297

  Fly   397 ASASSHKTLTAMVYYQQQPQQHQTQQQQQQYQQQQTTQLPVQLQLQHPLLQTGGDGKQSVYAPPT 461
                             ||.
Mouse   298 -----------------QPW--------------------------------------------- 300

  Fly   462 VQLRKQSRFNARKKFQFAILVIRAIIRIRRLRFTAEPLHVEEAIRDPYRVKVLRKVIDGCAFRVY 526
                   ....|::|:.|:..|.|..|:........||.....:||||.::.:|::||.||||:|
Mouse   301 -------NLTPRQRFRVAVWTILAAGRVALSSHRLRPLTKNALLRDPYALRPVRRLIDNCAFRLY 358

  Fly   527 GHWVKKGEGQNRAALFENTP 546
            ||||||||.|||||||::.|
Mouse   359 GHWVKKGEQQNRAALFQHQP 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	167/271 (62%)
Phkg2	NP_081164.2	Protein Kinases, catalytic domain	13..291	CDD:473864	171/278 (62%)
		Calmodulin-binding (domain-N). /evidence=ECO:0000250	306..330		5/23 (22%)
		Calmodulin-binding (domain-C). /evidence=ECO:0000250	346..370		17/23 (74%)